Green Chemistry, a Pharmaceutical Perspective

Abstract

As the Green Chemistry 1,2 movement has gained momentum, definitions of Green Chemistry have been dominated predominantly by academic viewpoints. Green Chemistry concepts, however, apply to an incredible diversity of scientific endeavor, which has invariably led to differences between and amongst both academia and industry regarding what constitutes Green Chemistry. Speaking primarily of the pharmaceutical industry and considering the advances achieved toward promoting Green Chemistry globally, 3 it is surprising how diverse the answers can be when executives, engineers, biologists, and chemists are asked the seemingly simple question "What is Green Chemistry?" Perhaps this should be expected considering that individual priorities change based upon a specific endeavor, altering the focus of Green Chemistry and consequently the message, making general definitions difficult. A common impression obtained appears to be that many do not accurately know or fully understand the true motivations, drivers, and deciding factors that serve to inspire and define Green Chemistry, and in particular Pharmaceutical Green Chemistry. This commentary seeks to shed light upon key aspects with regard to the philosophy of Pharmaceutical Green Chemistry.

Iridium(I) N‐Heterocyclic Carbene (NHC)/Phosphine Catalysts for Mild and Chemoselective Hydrogenation Processes

“…Furthermore and importantly,w ee nvisagedt hat the developed methodw ould be applicable in aw ide variety of more environmentally acceptable solvents. [12] We initiatedo ur studies by examining the nature of our developed catalyst speciesa nd evaluatedarange of NHC/phosphine complexes 3 in the hydrogenation of (E)-4-phenylbut-3-en-2-one 1a (Table 1). For comparison, we examined the reaction with Crabtree's catalyst 3a and found that only 31 %c onversionw as achieveda tt he low applied catalyst loading (entry 1).…”

Global Green Manufacturing Initiatives:A step forward in reducing pollution

“…But life saving drugs must be enabled. Some of green chemistry principles are used to meet goals to reduce environmental impact and higher efficiency through absolute best performance [10]. Green Chemistry principles carry environmental advantages to pharmaceutical companiesVarious environmental benefits are seen because of certain parameters.…”

“…Further, process efficiency is also improved. The above mentioned points reduce environmental burden [10].…”

Eco-Friendly Simultaneous Chromatographic Determination of Amiloride Hydrochloride, Atenolol, and Hydrochlorothiazide in Urine

“…Recently, the (bio)pharmaceutical industry introduced safety and health regulations to protect the environmental criteria for their products [1]. The using of toxic organic solvents for the synthesis and analysis of drugs is critical on a number of levels [2].…”