Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities

Abstract

Microwave-assisted organic synthesis, a green chemistry approach, is nowadays widely used in the drug synthesis. Microwaveassisted synthesis improves both throughput and turnaround time for medicinal chemists by offering the benefits of drastically reduced reaction times, increased yields, and pure products. Schiff bases are the important class of organic compounds due to their flexibility, and structural diversities due to the presence of azomethine group which is helpful for elucidating the mechanism of transformation and rasemination reaction in biological system. This novel compound could also act as valuable ligands for the development of new chemical entities. In the present work, some Schiff bases of Isatin derivatives was synthesized using microwave heating method. Schiff base of Isatin were synthesized by condensation of the keto group of Isatin with different aromatic primary amines. They were characterized by means of spectral data and subsequently subjected to the in vitro antibacterial activities against gram positive and gram negative strains of microbes. It was observed that the compound with electron withdrawing substituents exhibited good antibacterial activities against almost all the micro organisms.

Synthesis, antimicrobial and antioxidative activity of some new isatin derivatives

“…13 Another class of thiosemicarbazone derivates of isatin was found to exhibit interesting applications as research 1348 ŠEKULARAC et al tools in physiological studies. 32,33 Besides antimicrobial activity, the antioxidative capacities of a compound have become more and more significant nowadays. [29][30][31] Therefore the antimicrobial activity determination of this class of compounds is of significance and it has already been performed by the diameter of zone of inhibition method.…”

Synthesis of substituted 4-(3-chloro-2-oxo-4-phenylazetidin-1-yl)- 1, 5-dimethyl-2-phenyl-1, 2-dihydro-3H-pyrazol-3-one with Green Chemistry approach

“…Microwave is a form of electromagnetic energy which falls at the lower end of the electromagnetic spectrum and is defined in a measurement of frequency as 300 to 300,000 Megahertz [1] . The microwave region of the electromagnetic spectrum lies between infrared and radio frequencies.…”

“…The microwave region of the electromagnetic spectrum lies between infrared and radio frequencies. The basic mechanism of microwave assisted synthesis involves agitation of polar molecules or ions that oscillate under the effect of an oscillating electric or magnetic field [1] . In the presence of an oscillating field, particles try to orient themselves or be in phase with the field.…”

“…Only materials that absorb microwave radiation are relevant to microwave chemistry. These materials can be categorized according to the three main mechanisms of heating such as dipolar polarization, conduction mechanism, and interfacial polarization [1] .The microwave radiation is used as heating technique in organic synthesis. It has proven to be so efficient that it has gained wide acceptance in the field of organic chemistry.…”

Retracted: Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities

“…The paper titled "Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities" [1], published in Journal of Nanoparticles, has been retracted as it was accepted for publication on the basis of peer review reports that were submitted from fraudulent reviewer accounts.…”