Green methodologies in organic synthesis: recent developments in our laboratories

Abstract

The results of the studies carried out in our laboratories during the last 15 years, aimed at developing green methodologies for the synthesis of polyfunctionalized heteroaromatic substances, are surveyed. The results of the investigations demonstrate that green methodologies are not only less hazard than classical preparative methods but they also are more efficient and economical. For example, short reaction times and higher yields are observed for reactions in which conventional heating is replaced by microwave or ultrasound irradiation. The implementation of multicomponent reactions in green preparative routes also reduces the cost of carrying out the reactions because multiple separation and crystallization steps are avoided. In general, by employing the new green methodologies we have been able to produce a large number of polyfunctional aromatic substances in a highly efficient manner.

Greening the organic chemistry laboratory: a comparison of microwave-assisted and classical nucleophilic aromatic substitution reactions

“…Furthermore, the present study serves as an excellent introduction to microwave-induced organic reaction enhancement (MORE) which has been shown to be very useful in affecting the pathway of a reaction, the products formed and, especially, reaction times. As such, MORE techniques are appearing more often in the chemical literature (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). In one study (39), the authors report that the time and yield of their own previously developed synthesis of 2-chloromethylbenzothiazole from ortho-aminothiophenol and polyphosphoric acid, which gives a reasonable yield of 62% after 8 h of reflux at 180°C, improves to a 90% yield with only 10 min of microwave irradiation.…”

Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives

“…With developing need towards greener approaches, the use and modification of traditional methodologies is the need of the present, and in such a circumstance, PEG might be the solvent of higher preference because of its versatile blessings as a green reaction media. Since the arrival of green chemistry, various green chemistry orientated synthetic methods have been progressed so one can synthesize a wide variety of compounds without or less environmental hazard . One such strategy which has pulled brilliant attention of researchers in the organic synthesis using benign reaction media.…”

Green synthesis approach for Fe (III), Cu (II), Zn (II) and Ni (II)‐Schiff base complexes, spectral, conformational, MOE‐docking and biological studies

“…In this study, a green route of synthesis, was the considered approach, to synthesize new Schiff base complexes. In continuation of our work, we aim synthesis through such fast environmentally friendly procedure, which is very interesting. Effective ball‐milling methodology for quantitative production of new Fe (III), Zn (II), Cu (II), and Ni (II)‐ Schiff base complexes, will be described.…”