Green Peptide–nanomaterials; A Friendly Healing Touch for Skin Wound Regeneration

Abstract

The complex phenomenon by which the body responds to any injury of skin or tissue is known as wound healing. A number of phases like exudative, proliferative, and extracellular matrix remodeling are orchestrated events to be occurred involving blood cells, parenchymal cells, and different soluble mediators. Different internal, as well as external factors, regulate the speed and quality of healing. The delay in wound healing process causes the chronic wound or scar formation. At the present moment, the upscale research for identification of agents causing accelerated healing is important. Moreover, the biocompatibility of the accelerators needs to be investigated. Recent biomedical researches for wound care target to provide antimicrobial protection as well as matrix scaffolding for quick repairing of the skin tissue. In recent studies with natural peptides have shown that they are important components in developing the nano-medicines for their usefulness and therapeutic efficiency. New therapeutic formulations can be developed using these natural peptides utilizing different nanoparticle delivery system. This review deals with the developmental study on efficient wound care system where the possible use of natural peptides in combination with nanomaterials has been explored. A trial has also been made on the findings made over the past few years on the use of peptides as tissue regenerating agents through effective wound healing pathway.

Antimicrobial Activity of Blow Spun PLA/Gelatin Nanofibers Containing Green Synthesized Silver Nanoparticles against Wound Infection-Causing Bacteria

“…The main role of wound dressing includes maintaining wound hydration, absorbing excess wound secretions, minimizing the impact on the wound site, and as a barrier to the entry of foreign microorganisms into the wound site [ 17 , 18 , 19 ]. The nanofiber dressings as a product of nanotechnology were designed to decrease infection, irritation and improve wound healing by providing a positive environment in addition to their usual duties [ 20 , 21 ]. In comparison with macro-scale dressings, nanofibers contain more moisture in their structure and keep the wound area moist during the healing process.…”

Green Synthesis of Silver Nanoparticles Using Waste Tea Leaves

“…[37]. The wound healing properties of silver are reported in many in vivo studies where AgNPs promoted the healing process directly by reducing the cytokine-modulated inflammation [38]. The chance of infection can be decreased by covering the wounded area with these nanocoated bandages as reported by B. Pannerselvam et al in their study wherein they found increased wound recovery with increasing concentration of AgNPs [39].…”