Green synthesis and structural characterization of gold nanoparticles from Achillea wilhelmsii leaf infusion and in vitro evaluation

Asariha, Maryam; Chahardoli, Azam; Karimi, Nadia; Gholamhosseinpour, Maryam; Khoshroo, Alireza; Nemati, Houshang; Shokoohinia, Yalda; Fattahi, Ali

doi:10.1007/s12034-019-2005-z

Cited by 24 publications

(25 citation statements)

References 45 publications

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“…Aerial parts of A. wilhelmsii were defatted with n-hexane and subjected to consecutive Soxhlet extraction with dichloromethane (DCM), acetone, and methanol (MeOH) to obtain an exhaustive extraction of secondary metabolites. A previous report from our group had estimated the highest total phenolic content (gallic acid equivalent, GAE) and total flavonoid content (quercetin equivalent, QE) of A. wilhelmsii extracts to be 1393 µg GAE and 707 µg QE at concentration 300 µg/mL, respectively [11]. Thus, as expected, DCM and acetone extracts proved to be rich in apolar terpenoids and flavonoids, while the MeOH extract concentrated the glycosylated compounds.…”

Section: Chemical Analysis and Structure Elucidation Of Wilhelmsin And Wilhelmsolidesupporting

confidence: 70%

“…DCM2-D was further purified using a semi-preparative HPLC (gradient from 70% MeOH in water to 100%) to achieve pure leukodin (1, 62.0 mg). DCM2-F was purified in the same conditions as DCM2-D and afforded pure hanphyllin (8, 23.2 mg), penduletin (11,43.0 mg), artemetin (12, 32.6 mg), and salvigenin (14, 88.5 mg). DCM2-G was purified in the same conditions as DCM2-D and afforded pure santoflavone (13, 11.6 mg).…”

Section: Plant Collection Extraction and Purificationmentioning

confidence: 99%

“…Herein, we report the results of a comprehensive phytochemical investigation of A. wilhelmsii aerial part that led to the identification of 17 secondary metabolites (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), including the not yet described sequiterpenoids wilhelmsin (7) and wilhelmsolide (9). The structural elucidation for these new secondary metabolites, including peculiar structural features, was as well performed.…”

Section: Introductionmentioning

confidence: 97%

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Salvigenin, a Trimethoxylated Flavone from Achillea Wilhelmsii C. Koch, Exerts Combined Lipid-Lowering and Mitochondrial Stimulatory Effects

et al. 2021

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Phytochemical analysis of the Iranian plant Achillea wilhelmsii led to the isolation of 17 pure secondary metabolites belonging to the classes of sesquiterpenoids and phenolics. Two of these compounds, named wilhemsin (7) and wilhelmsolide (9), are new sesquiterpenoids, and the first shows undescribed structural features. Their structures were elucidated through extensive spectroscopic analysis, mainly based on 1D and 2D NMR, and chemical derivatization. Starting from plant traditional use and previous reports on the activity of the plant extracts, all the pure compounds were evaluated on endpoints related to the treatment of metabolic syndrome. The sesquiterpene hanphyllin (8) showed a selective cholesterol-lowering activity (−12.7% at 30 µM), santoflavone (13) stimulated glucose uptake via the GLUT transporter (+16.2% at 30 µM), while the trimethoxylated flavone salvigenin (14) showed a dual activity in decreasing lipid levels (−22.5% palmitic acid biosynthesis at 30 µM) and stimulating mitochondrial functionality (+15.4% at 30 µM). This study further confirms that, in addition to the antioxidants vitexin, isovitexin, and isoschaftoside, A. wilhelmsii extracts contain molecules that can act at different levels on the metabolic syndrome symptoms.

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Section: Chemical Analysis and Structure Elucidation Of Wilhelmsin And Wilhelmsolidesupporting

confidence: 70%

Section: Plant Collection Extraction and Purificationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Salvigenin, a Trimethoxylated Flavone from Achillea Wilhelmsii C. Koch, Exerts Combined Lipid-Lowering and Mitochondrial Stimulatory Effects

et al. 2021

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“…Antibacterial activity of AuNPDam (200, 400, 600, and 800 μg/ml) was analysed at high concentrations (Asariha et al, 2020) to observe possible effects against V . parahaemolyticus and A .…”

Section: Methodsmentioning

confidence: 99%

Green synthesis of gold nanoparticles using Turnera diffusa Willd enhanced antimicrobial properties and immune response in Longfin yellowtail leukocytes

Reyes‐Becerril¹,

Ruvalcaba²,

Sánchez³

et al. 2021

Aquaculture Research

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Plant‐mediated nanoparticle synthesis is an eco‐friendly method designed to reduce toxicity. This research reports the effects of gold nanoparticle green synthesis on immune modulation for the first time, using aqueous extract from Turnera diffusa. First, the chemical composition showed that T. diffussa is abundant in compounds, such as oplopanone, γ‐eudesmol, hydroquinone‐β‐d‐glucoside (arbutin) and inositol. The synthesized gold nanoparticles (AuNPDam) were confirmed by ultraviolet visible (UV‐Vis) spectrophotometry; the micro‐graphical analysis confirmed the average size that was estimated about 24 nm, which were mostly spherical in shape. The Fourier transform infrared spectroscopy (FTIR) technique helped to confirm the functional groups of the synthesized AuNPDam. Its antioxidant capability was analysed using 2,2‐diphenyl‐1‐picrylhydarzyl (DPPH), superoxide radical scavenging and fluorescence recovery after photobleaching (FRAP) methods. These results indicated a worthy antioxidant activity. The synthesized AuNPDam showed strong antibacterial activity against Vibrio parahaemolyticus and Aeromonas hydrophila. Interestingly, AuNPDam were nontoxic to Longfin yellowtail head kidney leukocytes after 24 h. The phagocytosis activity, production of reactive oxygen species and nitric oxide were also enhanced in leukocytes treated with AuNPDam. Overall, the results suggested that AuNPDam is non‐cytotoxic, displays strong bactericidal activity and has therapeutic properties by enhancing the immune system.

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“…[ 32 ] Because of this, intense researches have been directed to the development and exploitation of green approaches and efficient synthesis of AgNPs. [ 33–35 ]…”

Section: Introductionmentioning

confidence: 99%

A Simple Method for Developing a Hand‐Drawn Paper‐Based Sensor for Mercury; Using Green Synthesized Silver Nanoparticles and Smartphone as a Hand‐Held‐Device for Colorimetric Assay

et al. 2021

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Mercury ions are highly toxic at trace levels, and its pollution has posed a significant threat to the environment and public health, where current detection methods mainly require laborious operation and expensive instrumentation. Herein, a simple, cost‐effective, instrument‐free approach for selective detection of Hg2+ based on a hand‐drawn paper‐based naked‐eye colorimetric device is developed. To develop a hand‐drawn paper‐based device, a crayon is used to build hydrophobic barriers and a paper puncher is applied to obtain patterns as a sensing zone. A green method for the synthesis of silver nanoparticles (AgNPs) is applied using Achillea Wilhelmsii (Aw) extract. The sensing ability of Aw‐AgNPs toward Hg2+ is investigated in both solution‐phase and paper substrate loaded with Aw‐AgNPs using colorimetric methods. For the paper‐based sensor, the quantification of the target relies on the visual readout of a color‐changed sensing zone modified with Aw‐AgNPs. Under optimal conditions, the color of Aw‐AgNPs in aqueous solution and on the coated paper substrate can change from brown to colorless upon addition of target, with a detection limit of 28 × 10−9 m and 0.30 × 10−6 m, respectively. In conclusion, the present study indicates the potential of this hand‐drawn eco‐friendly paper‐based sensor for monitoring of mercury.

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Green synthesis and structural characterization of gold nanoparticles from Achillea wilhelmsii leaf infusion and in vitro evaluation

Cited by 24 publications

References 45 publications

Salvigenin, a Trimethoxylated Flavone from Achillea Wilhelmsii C. Koch, Exerts Combined Lipid-Lowering and Mitochondrial Stimulatory Effects

Salvigenin, a Trimethoxylated Flavone from Achillea Wilhelmsii C. Koch, Exerts Combined Lipid-Lowering and Mitochondrial Stimulatory Effects

Green synthesis of gold nanoparticles using Turnera diffusa Willd enhanced antimicrobial properties and immune response in Longfin yellowtail leukocytes

A Simple Method for Developing a Hand‐Drawn Paper‐Based Sensor for Mercury; Using Green Synthesized Silver Nanoparticles and Smartphone as a Hand‐Held‐Device for Colorimetric Assay

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