Green synthesis, characterization and evaluation of catalytic and antibacterial activities of chitosan, glycol chitosan and poly(γ-glutamic acid) capped gold nanoparticles

Inbaraj, Baskaran Stephen; Chen, Bang‐Yuan; Liao, Chia-Wei; Chen, Bing‐Huei

doi:10.1016/j.ijbiomac.2020.07.244

Cited by 47 publications

(23 citation statements)

References 49 publications

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“…Chitosan could provide substantial electrostatic stability to the nanoparticles by rendering surface charge adequately. 9 This could be seen from their zeta potential as well because zeta potential is used as an indication of physical stability. 10 AgNPs without chitosan as a stabilizing agent had negative zeta potential of -5 ± 1 mV.…”

Section: Formation and Characteristics Of Biosynthesized Agnpsmentioning

confidence: 99%

Biosynthesized silver nanoparticles loaded in gelatine hydrogel for a natural antibacterial and anti-biofilm wound dressing

Katas

Akhmar

Abdalla

2021

Journal of Bioactive and Compatible Polymers

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Antibiotic-resistance and bacterial bioburden are the threats to wound healing. Nanoparticles are a revolutionary advancement in nanomedicine owing to their antibacterial properties, to be used as a promising alternative to antibiotics. A wound dressing with antibacterial and anti-biofilm effects may be a plausible strategy in curbing wound exacerbation caused by bacterial infection. Silver nanoparticles (AgNPs) are known for their excellent antibacterial activity. In present study, biosynthesized AgNPs using spent mushroom substrate (SMS) as reducing agent while chitosan as stabilizing agent were successfully produced. The nanoparticles exhibited considerable antibacterial and anti-biofilm activities with higher sensitivity towards Gram-negative bacteria. These AgNPs were later incorporated into genipin-crosslinked gelatine hydrogels as a wound dressing. The hydrogels were characterized for their physical, rheological and swelling properties, besides in vitro release of AgNPs. The formulated hydrogels demonstrated an adequate release of the AgNPs with acceptable physical, rheological and swelling properties, suitable as a vehicle for wound drug delivery. The antibacterial and anti-biofilm of the hydrogels against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli were effective in inhibiting the growth of the selected bacteria with minimum inhibitory concentration (MIC) of 63 μg/mL. In summary, genipin-crosslinked gelatine hydrogels loaded with the AgNPs are a promising anti-microbial wound dressing, a potential strategy for combating biofilm of wound infections and accelerating healing.

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Section: Formation and Characteristics Of Biosynthesized Agnpsmentioning

confidence: 99%

Biosynthesized silver nanoparticles loaded in gelatine hydrogel for a natural antibacterial and anti-biofilm wound dressing

Katas

Akhmar

Abdalla

2021

Journal of Bioactive and Compatible Polymers

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“…A method based on Kimling et al [15] and Inbaraj et al [16] was modified to prepare the GNPs. One mL of gold (III) chloride trihydrate solution was mixed with 1 mL of deionized water in a tube, followed by heating on a plate at 75 • C and stirring for 20 min at 1000 rpm Then, 3 mL of 5 mM sodium citrate solution was added with continued heating and stirring until the solution color turned red, and 5 mL of the GNPs was obtained.…”

Section: Preparation Of Gold Nanoparticle (Gnps) and Resveratrol-gold Nanoparticle (R-gnps)mentioning

confidence: 99%

Comparative Study on Inhibition of Pancreatic Cancer Cells by Resveratrol Gold Nanoparticles and a Resveratrol Nanoemulsion Prepared from Grape Skin

2021

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Resveratrol, a phenolic compound possessing vital biological activities such as anti-cancer, is present abundantly in grape skin, a waste produced during the processing of grape juice. The objectives of this study were to prepare resveratrol-gold nanoparticles and a resveratrol nanoemulsion from grape skin and study their inhibition effects on pancreatic cancer cells BxPC-3. The spherical-shaped citrate gold nanoparticles (GNPs) and resveratrol-gold nanoparticles (R-GNPs) were, respectively, prepared with a surface plasmon resonance peak at 528 and 538 nm, mean particle size of 20.8 and 11.9 nm, and zeta-potential at −32.7 and −66.7 mV, by controlling an appropriate concentration of citrate/resveratrol and gold chloride as well as stirring time and temperature. The resveratrol nanoemulsion, composed of soybean oil, Tween 80, and sucrose fatty acid ester in glycerol and water, possessed a high storage stability with a mean particle size of 14.1 nm, zeta-potential of −49.7 mV, and encapsulation efficiency of 95.5%. An antiproliferation study revealed that both R-GNPs and resveratrol nanoemulsion could effectively inhibit the growth of pancreatic cancer cells BxPC-3, with the latter showing a higher inhibition effect. Western blot analysis implied that both can down-regulate expressions of cyclin A, cyclin B, CDK1, and CDK2 and up-regulate expressions of p53 and p21, accompanied by enhancing cytochrome C expression, decreasing BcL-2 expression, increasing Bax expression, and leading to the elevation of caspase-8, caspase-9, and caspase-3 activities for cell apoptosis execution. Future research is needed to study the inhibition of pancreatic tumors in vivo by R-GNPs and resveratrol nanoemulsions.

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“…This reaction was also used to test the catalytic activity of gold nanoparticles embedded in magnolia leaves, which resulted in active and reusable catalysts due to their structure [160], and to test the activity of four types of biopolymer-capped gold nanoparticles. Poly(-glutamic acid) gold nanoparticles showed 4-6 times more activity in this chemical reaction and could also be used as an antibacterial agent as they inhibited Salmonella enterica and Escherichia coli growth more efficiently than gentamycin [161] Qin et al used pollen grains as a template to produce TiO 2 /C and SiO 2 /C microellipsoids with immobilized Fe 2 O 3 in the pores to use in the pho-tocatalytic degradation of X-3B dye, which was favored by the hollow and hierarchically porous structure of the biotemplated composite [162].…”

Section: B) Decontamination Reactionsmentioning

confidence: 99%

Bio-Templating: An Emerging Synthetic Technique for Catalysts. A Review

et al. 2021

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In the last few years, researchers have focused their attention on the synthesis of new catalyst structures based on or inspired by nature. Biotemplating involves the transfer of biological structures to inorganic materials through artificial mineralization processes. This approach offers the main advantage of allowing morphological control of the product, as a template with the desired morphology can be pre-determined, as long as it is found in nature. This way, natural evolution through millions of years can provide us with new synthetic pathways to develop some novel functional materials with advantageous properties, such as sophistication, miniaturization, hybridization, hierarchical organization, resistance, and adaptability to the required need. The field of application of these materials is very wide, covering nanomedicine, energy capture and storage, sensors, biocompatible materials, adsorbents, and catalysis. In the latter case, bio-inspired materials can be applied as catalysts requiring different types of active sites (i.e., redox, acidic, basic sites, or a combination of them) to a wide range of processes, including conventional thermal catalysis, photocatalysis, or electrocatalysis, among others. This review aims to cover current experimental studies in the field of biotemplating materials synthesis and their characterization, focusing on their application in heterogeneous catalysis.

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Green synthesis, characterization and evaluation of catalytic and antibacterial activities of chitosan, glycol chitosan and poly(γ-glutamic acid) capped gold nanoparticles

Cited by 47 publications

References 49 publications

Biosynthesized silver nanoparticles loaded in gelatine hydrogel for a natural antibacterial and anti-biofilm wound dressing

Biosynthesized silver nanoparticles loaded in gelatine hydrogel for a natural antibacterial and anti-biofilm wound dressing

Comparative Study on Inhibition of Pancreatic Cancer Cells by Resveratrol Gold Nanoparticles and a Resveratrol Nanoemulsion Prepared from Grape Skin

Bio-Templating: An Emerging Synthetic Technique for Catalysts. A Review

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