Green synthesis, characterization, antibacterial, and antifungal activity of copper oxide nanoparticles derived from Morinda citrifolia leaf extract

Priya, Manogar; Venkatesan, Raja; Deepa, Simon; Sana, Siva Sankar; Arumugam, Soundhar; Karami, Abdulnasser M.; Vetcher, Alexandre A.; Kim, Seong-Cheol

doi:10.1038/s41598-023-46002-5

Cited by 35 publications

(7 citation statements)

References 78 publications

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“…The bactericidal activity is attributed to the release of metallic ions and the close interaction of the NPs with the bacterial membrane. CuO NPs exhibit enhanced microbicidal activity against various pathogenic microbes 29 . Cu NPs accumulate on the surface of bacterial cells, decreasing the transmembrane electrochemical potential, which disrupts the membrane integrity.…”

Section: Resultsmentioning

confidence: 99%

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NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing

Ullah,

Khan,

Ahmad

et al. 2024

Commun Chem

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Nanoparticle-based therapies are emerging as a pivotal frontier in biomedical research, showing their potential in combating infections and facilitating wound recovery. Herein, selenium-tellurium dopped copper oxide nanoparticles (SeTe-CuO NPs) with dual photodynamic and photothermal properties were synthesized, presenting an efficient strategy for combating bacterial infections. In vitro evaluations revealed robust antibacterial activity of SeTe-CuO NPs, achieving up to 99% eradication of bacteria and significant biofilm inhibition upon near-infrared (NIR) irradiation. Moreover, in vivo studies demonstrated accelerated wound closure upon treatment with NIR-activated SeTe-CuO NPs, demonstrating their efficacy in promoting wound healing. Furthermore, SeTe-CuO NPs exhibited rapid bacterial clearance within wounds, offering a promising solution for wound care. Overall, this versatile platform holds great promise for combating multidrug-resistant bacteria and advancing therapeutic interventions in wound management.

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Section: Resultsmentioning

confidence: 99%

“…Owing to the low in vivo toxicity, Cu can be used for the surface coating of implants 25 , 26 . The antimicrobial capability of CuO NPs has already been demonstrated and exploited 27 – 29 . CuO NPs were effective against pathogenic bacteria involved in hospital acquired infections.…”

Section: Introductionmentioning

confidence: 99%

NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing

Ullah,

Khan,

Ahmad

et al. 2024

Commun Chem

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“…ZnO NPs' antibacterial activity against S. aureus and E. coli was evaluated via the zone of bacterial inhibition method (disc diffusion test) [66,67]. S. aureus and E. coli were cultured for twenty-four hours in a shaking incubator controlled at 35 • C with constant temperature and humidity.…”

Section: Biological Studies Of Zno Npsmentioning

confidence: 99%

A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton)

Sugitha,

Venkatesan,

Latha

et al. 2024

Molecules

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The green synthesis of zinc oxide nanoparticles (ZnO NPs) using plants has grown in significance in recent years. ZnO NPs were synthesized in this work via a chemical precipitation method with Jasminum sambac (JS) leaf extract serving as a capping agent. These NPs were characterized using UV-vis spectroscopy, FT-IR, XRD, SEM, TEM, TGA, and DTA. The results from UV-vis and FT-IR confirmed the band gap energies (3.37 eV and 3.50 eV) and the presence of the following functional groups: CN, OH, C=O, and NH. A spherical structure and an average grain size of 26 nm were confirmed via XRD. The size and surface morphology of the ZnO NPs were confirmed through the use of SEM analysis. According to the TEM images, the ZnO NPs had an average mean size of 26 nm and were spherical in shape. The TGA curve indicated that the weight loss starts at 100 °C, rising to 900 °C, as a result of the evaporation of water molecules. An exothermic peak was seen during the DTA analysis at 480 °C. Effective antibacterial activity was found at 7.32 ± 0.44 mm in Gram-positive bacteria (S. aureus) and at 15.54 ± 0.031 mm in Gram-negative (E. coli) bacteria against the ZnO NPs. Antispasmodic activity: the 0.3 mL/mL sample solution demonstrated significant reductions in stimulant effects induced by histamine (at a concentration of 1 µg/mL) by (78.19%), acetylcholine (at a concentration of 1 µM) by (67.57%), and nicotine (at a concentration of 2 µg/mL) by (84.35%). The antipyretic activity was identified using the specific Shodhan vidhi method, and their anti-inflammatory properties were effectively evaluated with a denaturation test. A 0.3 mL/mL sample solution demonstrated significant reductions in stimulant effects induced by histamine (at a concentration of 1 µg/mL) by 78.19%, acetylcholine (at a concentration of 1 µM) by 67.57%, and nicotine (at a concentration of 2 µg/mL) by 84.35%. These results underscore the sample solution’s potential as an effective therapeutic agent, showcasing its notable antispasmodic activity. Among the administered doses, the 150 mg/kg sample dose exhibited the most potent antipyretic effects. The anti-inflammatory activity of the synthesized NPs showed a remarkable inhibition percentage of (97.14 ± 0.005) at higher concentrations (250 µg/mL). Furthermore, a cytotoxic effect was noted when the biologically synthesized ZnO NPs were introduced to treated cells.

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“…Many of their outstanding applications include catalysis 9,10 , biological labeling 11,12 , drugs delivery 13,14 , tissue engineering 15,16 , optoelectronics 17,18 and wastewater remediation applications 19,20 . However, most reported synthetic approaches use organic solvents, hydrazine 21 , sodium borohydride 21 , as surfactants, stabilizers as well as the reducing agents 22 .…”

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confidence: 99%

“…A key advantage of Cu is its affordability and availability, rendering the production of CuNPs cost-effective. So far, CuNPs have been synthesized from several plant extracts 11,36 . However, the potentiality of using A. scholaris extracts is still not yet explored.…”

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confidence: 99%

Alstonia scholaris Leaves: A Biochemical Marvel for Eco-friendly Copper Nanoparticles Synthesis

Labaran,

Zango,

Tailor

et al. 2024

Preprint

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The utilization of plants for the production of metallic nanoparticles is gaining significant attention in research. In this study, we conducted phytochemical screening of Alstonia scholaris (A. scholaris) leaves extracts using various solvents, including chloroform, ethyl acetate, n-hexane, methanol, and water. Our findings revealed higher proportions of flavonoids and alkaloids in both solvents compared to other phytochemical species. In the methanol, extract proteins, anthraquinone and reducing sugar were not detected. On the other hand, the aqueous extract demonstrated the presence of amino acids, reducing sugar, phenolic compounds, anthraquinone, and saponins. Notably, ethyl acetate and chloroform extracts displayed the highest levels of bioactive compounds among all solvents. Intrigued by these results, we proceeded to investigate the antibacterial properties of the leaf extracts against two major bacterial strains, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). All extracts exhibited significant zones of inhibition against both bacterial isolates, with S. aureus showing higher susceptibility compared to E. coli. Notably, the methanol extract displayed the most potent I hibitory effect against all organisms. Inspired by the bioactivity of the methanol extract, we employed it as a plant-based material for the green synthesis of copper nanoparticles (Cu-NPs). The synthesized Cu-NPs were characterized using Fourier infrared spectroscopy (FT-IR), UV-visible spectroscopic analysis, and scanning electron microscopy (SEM). The observed color changes confirmed the successful formation of Cu-NPs, while the FTIR analysis matched previously reported peaks, further verifying the synthesis. The SEM micrographs indicated the irregular shapes of the surface particles. From the result obtained by energy dispersive x-ray (EDX) spectroscopic analysis, Cu has the highest relative abundance of 67.41 wt.%. confirming the purity of the Cu-NPs colloid. These findings contribute to the growing field of eco-friendly nanotechnology and emphasize the significance of plant-mediated approaches in nanomaterial synthesis and biomedical applications.

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Green synthesis, characterization, antibacterial, and antifungal activity of copper oxide nanoparticles derived from Morinda citrifolia leaf extract

Cited by 35 publications

References 78 publications

NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing

NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing

A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton)

Alstonia scholaris Leaves: A Biochemical Marvel for Eco-friendly Copper Nanoparticles Synthesis

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