Green synthesis of zinc oxide nanoparticles using leaf extracts of Raphanus sativus var. Longipinnatus and evaluation of their anticancer property in A549 cell lines

Umamaheswari, A; Prabu, S.; John, Sangeeth; Puratchikody, Ayarivan

doi:10.1016/j.btre.2021.e00595

Cited by 111 publications

(46 citation statements)

References 53 publications

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“…Intense changes in morphology were observed after treatment, and the authors suggested that the high surface area to volume ratio of ZnO NPs may lead to enhanced cytotoxicity. Moreover, phyto-constituents present in the plant from which ZnO NPs was synthesized might also be responsible for the enhanced anticancer activity of these NPs [ 153 ]. Similarly, the A549 cancer cell line was treated with various dosages of ZnO NPs ranging from 1 to 100 µg/mL produced from Pandanus odorifer leaf extract.…”

Section: In Vitro and In Vivo Anticancerous Activity Of Zno Npsmentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anjum

Hashim

Malik

et al. 2021

Cancers

275

102

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Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complications. Several metal oxide NPs are being developed to diagnose or treat malignancies, but zinc oxide nanoparticles (ZnO NPs) have remarkably demonstrated their potential in the diagnosis and treatment of various types of cancers due to their biocompatibility, biodegradability, and unique physico-chemical attributes. ZnO NPs showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. ZnO NPs have also been used as an effective carrier for targeted and sustained delivery of various plant bioactive and chemotherapeutic anticancerous drugs into tumor cells. In this review, at first we have discussed the role of ZnO NPs in diagnosis and bio-imaging of cancer cells. Secondly, we have extensively reviewed the capability of ZnO NPs as carriers of anticancerous drugs for targeted drug delivery into tumor cells, with a special focus on surface functionalization, drug-loading mechanism, and stimuli-responsive controlled release of drugs. Finally, we have critically discussed the anticancerous activity of ZnO NPs on different types of cancers along with their mode of actions. Furthermore, this review also highlights the limitations and future prospects of ZnO NPs in cancer theranostic.

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Section: In Vitro and In Vivo Anticancerous Activity Of Zno Npsmentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anjum

Hashim

Malik

et al. 2021

Cancers

275

102

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“…Figure 4. Various morphologies of ZnO NPs: (a) spot-like shaped,7 (b) caulifower-shaped,32 (c) flower-shaped,34 (d) hexagonal,34 (e) triangular,41 and (f) spherical 43. …”

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confidence: 99%

A review of the green synthesis of ZnO nanoparticles using plant extracts and their prospects for application in antibacterial textiles

Huang

Zhu

et al. 2021

Journal of Engineered Fibers and Fabrics

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In an era of environmentally friendly development, methods of the green synthesis of zinc oxide nanoparticles (ZnO NPs) from plant extracts have become a focus of research attention because of the benefits of environmental sustainability, simplicity, and low price. The present review introduces a green mechanism for the synthesis of ZnO NPs using the extracts of plants, exploring factors that influence the morphology of ZnO NPs and their antibacterial properties, and the mechanisms of antibacterial action. The results indicate that the factors that influence morphology include the intrinsic crystallographic morphological properties and conditions of the preparation of ZnO NPs. In terms of preparation conditions, the influence of plant extract concentration, precursor concentration, reaction time, and calcination temperature on NP morphology is related to the species of plants used, with precursor concentration the most significant factor affecting the morphology of ZnO NPs. A pH of 12 appears be the most appropriate alkalinity for the synthesis of ZnO NPs from plant extracts. In addition, the synthesized ZnO NPs display excellent antibacterial properties, the mechanism of which involves photocatalysis, reactive oxygen species, and interactions between ZnO NPs and bacterial surfaces. Factors influencing the antibacterial properties are the type of bacteria and the concentration and morphology of ZnO NPs. Finally, the methods of preparation of antibacterial textiles using synthetic ZnO NPs are discussed in relation to the preparation of antibacterial fibers, fabric, and composite textiles. Here, the future trend of such antibacterial textiles is considered, providing the direction for further research of antibacterial textiles.

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“…[ 22 , 23 , 24 , 25 ]. Among the different sources, plants are considered to be vastly available and are known to possess phytoconstituents that are reported to be beneficial in various ways to humankind [ 26 , 27 , 28 , 29 ]. Plant parts such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds have been extensively used for the synthesis of zinc oxide nanoparticles in the recent past and are found to be stable, highly pure, cost-effective, and possess greater biomedical properties [ 30 , 31 ].…”

Section: Synthesis Of Zinc Oxide Nanoparticles From Plantsmentioning

confidence: 99%

“…Zinc oxide nanoparticles have a particle size, shape, surface charge, concentration, and time-dependent cytotoxicity in cancer cells, and photo-irradiation with ultraviolet (UV) or near-infrared (NIR) lasers enhance its anticancer activity through a synergistic chemo-photodynamic effect [ 29 , 71 ]. The majority of the researchers also demonstrated that zinc oxide nanoparticles are less or nontoxic compared to normal cells in vitro when used in the same concentration range as cancer cells.…”

Section: Biomedical Applications Of Plant-mediated Zinc Oxide Nanoparticlesmentioning

confidence: 99%

“…Faisal et al [ 11 ] used the Streptomyces 85E strain to elucidate the protein kinase inhibition capability of zinc oxide nanoparticles synthesized from aqueous fruit extracts of M. fragrans and concluded that the plant extracts provide crucial capping and stabilizing agents to biogenic nanoparticles, which are responsible for their anticancer properties. Recently, Umamaheswari et al [ 29 ] reported that the anticancer activity of zinc oxide nanoparticles biosynthesized from leaf extracts of Raphanus sativus was higher after treating the A549 cell lines, indicating that cancer drugs can be prepared using this environmentally friendly method. The DNA damage pathways, paraptosis, autophagy, radio sensitizing, aberrant cellular metabolism, overcoming chemo resistance, oxidative stress modulation, induction of apoptosis, arresting of the cancer cell cycle, anti-invasion, and metastasis are some of the possible anticancer mechanisms that have been reported so far [ 139 ].…”

Section: Biomedical Applications Of Plant-mediated Zinc Oxide Nanoparticlesmentioning

confidence: 99%

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Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

et al. 2021

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Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. This review also covers the drug delivery application of plant-mediated zinc oxide nanoparticles, focusing on the drug-loading mechanism, stimuli-responsive controlled release, and therapeutic effect. Finally, the future direction of these synthesized zinc oxide nanoparticles’ research and applications are discussed.

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Green synthesis of zinc oxide nanoparticles using leaf extracts of Raphanus sativus var. Longipinnatus and evaluation of their anticancer property in A549 cell lines

Cited by 111 publications

References 53 publications

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

A review of the green synthesis of ZnO nanoparticles using plant extracts and their prospects for application in antibacterial textiles

Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

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