Green Synthesized Silver Nanoparticles: Toxicity Against Poecilia reticulata Fishes and Ceriodaphnia cornuta Crustaceans

Ishwarya, Ramachandran; Vaseeharan, Baskaralingam; Shanthi, S.; Subramani, Ramesh; Manogari, Pitchaimani; Dhanalakshmi, K.; Vijayakumar, Sekar; Benelli, Giovanni

doi:10.1007/s10876-016-1126-4

Cited by 20 publications

(3 citation statements)

References 25 publications

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“…AgNPs at 40 µg/mL led to remarkable DNA damage in adults of the microcrustacean C . cornuta , whereas in larvae of P. reticulata , 20 µg/mL AgNPs led to DNA damage [69]. Notably, AgNPs produced micronuclei and nuclear abnormalities such as blebbed nuclei, lobed nuclei, and notched nuclei in peripheral blood cells of zebrafish ( D. rerio ), indicating genotoxicity [70].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

et al. 2019

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Background and objectives: Although studies have elucidated the significant biomedical potential of biogenic metallic nanoparticles (MNPs), it is very important to explore the hazards associated with the use of biogenic MNPs. Evidence indicates that genetic toxicity causes mutation, carcinogenesis, and cell death. Materials and Methods: Therefore, we systematically review original studies that investigated the genotoxic effect of biologically synthesized MNPs via in vitro and in vivo models. Articles were systematically collected by screening the literature published online in the following databases; Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and EBSCO. Results: Most of the studies were carried out on the MCF-7 cancer cell line and phytosynthesis was the general approach to MNP preparation in all studies. Fungi were the second most predominant resource applied for MNP synthesis. A total of 80.57% of the studies synthesized biogenic MNPs with sizes below 50 nm. The genotoxicity of Ag, Au, ZnO, TiO2, Se, Cu, Pt, Zn, Ag-Au, CdS, Fe3O4, Tb2O3, and Si-Ag NPs was evaluated. AgNPs, prepared in 68.79% of studies, and AuNPs, prepared in 12.76%, were the two most predominant biogenic MNPs synthesized and evaluated in the included articles. Conclusions: Although several studies reported the antigenotoxic influence of biogenic MNPs, most of them reported biogenic MNP genotoxicity at specific concentrations and with a dose or time dependence. To the best of our knowledge, this is the first study to systematically evaluate the genotoxicity of biologically synthesized MNPs and provide a valuable summary of genotoxicity data. In conclusion, our study implied that the genotoxicity of biologically synthesized MNPs varies case-by-case and highly dependent on the synthesis parameters, biological source, applied assay, etc. The gathered data are required for the translation of these nanoproducts from research laboratories to the clinical market.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

et al. 2019

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“…For example, Kisin et al [90] reported that single-wall carbon nanotubes (SWCNTs) caused single-and double-strand DNA lesions in Chinese hamster fibroblasts (V79 cell line) at 96 µg/cm 2 . In a different study, AgNPs at different concentrations were found to cause significant DNA damage in S. cerevisiae [91], larvae of the mulberry silkworm [92], adults of the microcrustacean C. cornuta [93], and abnormalities in micronuclei and nuclear of zebrafish (D. rerio) [94]. AgNPs' genotoxicity was also reported in microbes [95,96] and plants [97][98][99].…”

Section: Genotoxicity Of Nanoparticlesmentioning

confidence: 99%

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Egbuna

Parmar

Jeevanandam

et al. 2021

Journal of Toxicology

193

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Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.

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“…Generally, the eco-toxicity investigative studies have been conducted on model organisms (such as bacteria, fungi, algae, small crustaceans, worms, shrimp, rats and fish) when exposed to AgNPs in a uniform experimental medium setup (such as sediment, solid media and water) for limited duration (1day to 8-weeks) [169,174,177,182]. Hence, it is possible to determine the toxic effects and mechanisms involved in the toxicity of AgNPs in regard to specific organism or species.…”

Section: Challenges Involved In Risk Assessmentmentioning

confidence: 99%

A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

Velidandi¹,

Dahariya²,

Pabbathi³

et al. 2020

NanoWorld

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In recent years, fabrication of AgNPs via plant extracts has gained much attention because of being environmentally friendly, non-hazardous and cost effective. The bio-fabrication of AgNPs using plant extracts as reducing, capping and stabilizing agents includes simpler, safer, less-toxic and energy efficient. AgNPs have been widely applied in numerous fields due to their bio-compatibility, multifunctionality, solubility, high stability, therapeutic and adhesive properties. This review focuses on the advantages of AgNPs synthesis using plant extracts and its applications in various fields for the betterment of mankind and environment with numerous examples and also highlights on explaining possible fundamental mechanisms involved in antimicrobial and anticancer activities of plant extract synthesized AgNPs.

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Green Synthesized Silver Nanoparticles: Toxicity Against Poecilia reticulata Fishes and Ceriodaphnia cornuta Crustaceans

Cited by 20 publications

References 25 publications

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

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