Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats

Messarah, Mahfoud; Saoudi, Mongi; Boumendjel, Amel; Kadeche, Lilia; Boulakoud, Mohamed Salah; Feki, Abdelfattah El

doi:10.1177/0748233711433934

Cited by 33 publications

(17 citation statements)

References 72 publications

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“…Manimaran et al 30 have reported that presence of arsenic leads to increased level of MDA in renal tissue. Messarah et al 31 have reported that arsenic causes increased level of TBARS, being used in the evaluation of lipid peroxidation, in renal tissue. Huang et al 32 have conducted a study with 290 adults who were exposed to arsenic and reported that levels of MDA and 8-hydroxy-2 0 -deoxyguanosine, used as an indicator of DNA damage, and that urine arsenic level was positively correlated with these indicators.…”

Section: Discussionmentioning

confidence: 99%

“…25 It has been monitored in some studies that As increased activities of the oxidant enzymes such as heme oxygenase-1, cyclooxygenase-2 and NADPH that were considered to responsible for the production of arsenic. [30][31][32] ROS leads to oxidation of macromolecules, mainly cell membrane lipids, proteins and DNA. The oxidation of lipids in the cell membrane causes changes in the membrane characteristics and starts a process that leads up to complete loss of the cell.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. Rats were divided into three groups. Physiological serum in 10 mL/kg dose as intragastric was given to the control group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) was given to the arsenic group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) and TQ (10 mg/kg, intragastric by gavage for 15 days) was given to the arsenic + TQ group. After 15 days, the animals' kidneys were taken theirs, then we have performed histological and apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde (MDA) levels have examined as the oxidative stress parameters. We have determined the levels of arsenic. Increased renal injury and apoptotic cells have been detected in the arsenic group. Degenerative changes in the arsenic + TQ group were diminished. Although the MDA levels were augmented in the arsenic group, SOD, CAT and GSH-Px enzyme activities were lessened than the other groups. Our findings suggest that TQ may impede the oxidative stress, the cells have been damaged and also the generation of apoptotic cells arisen from arsenic. TQ plays a protective role against arsenic-induced toxicity in kidney and may potentially be used as a remedial agent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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“…miały na celu zbadanie wpływu wodnego roztworu zielonej herbaty (green tea -GT) na wywołane przez arsen skutki toksyczne i peroksydację lipidów [33]. Doświadczenie prowadzono na szczurach (28 szczurów).…”

Section: Trójtlenek Arsenu a Inne Substancjeunclassified

“…Jednoczesne zastosowanie GT spowodowało spadek wymienionych parametrów biochemicznych. Autorzy wysunęli więc wniosek, że ekspozycja na arsen powoduje wzrost stresu oksydacyjnego, jednak stosowanie wodnego roztworu zielonej herbaty może łago-dzić toksyczne działanie arsenu [33].…”

Section: Trójtlenek Arsenu a Inne Substancjeunclassified

Arsenic – Poison or medicine?

Kulik-Kupka¹,

Koszowska²,

Brończyk-Puzoń³

et al. 2016

Med Pr

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StreszczenieArsen to pierwiastek kojarzony głównie z działaniem toksycznym. Należy jednak podkreślić, że mimo toksyczności jest on stosowany w medycynie. W przeszłości arsen i jego związki wykorzystywano w leczeniu m.in. cukrzycy, łuszczycy, kiły, owrzodzeń skóry i chorób stawów. Obecnie stosowany jest w onkologii, głównie u pacjentów z ostrą białaczką promielocytową. Z jednej strony więc arsen został uznany przez Międzynarodową Agencję Badań nad Rakiem (International Agency for Research on Cancer -IARC) za pierwiastek o udowodnionym epidemiologicznie rakotwórczym działaniu, a z drugiej -jest wykorzystywany w terapii chorób onkologicznych. Na działanie arsenu człowiek jest narażony także w codziennym życiu, ponieważ jest to substancja szeroko rozpowszechniona w przyrodzie. Występuje w glebie i wodzie, co skutkuje przedostawaniem się tego związku do pożywienia. Długotrwała ekspozycja na arsen i jego związki może doprowadzić np. do zmian w mięśniu sercowym lub uszkodzenia wątroby. Z tego powodu ważne jest prowadzenie monitoringu zawartości tej substancji w glebie, wodzie i pożywieniu, a także możliwości narażenia zawodowego. Niezbędne jest także ustalenie norm zawartości tego pierwiastka (zarówno zawartości całkowitej, jak i jego nieorganicznej formy) w pożywieniu. Niniejszy artykuł jest przeglądem publikacji znajdujących się w bazach medycznych PubMed oraz Polskiej Bibliografii Lekarskiej, które ukazały się do 2015 r. oraz dotyczyły arsenu i jego związków. W artykule przedstawiono najważniejsze informacje dotyczące arsenu -zarówno jako trucizny, jak i leku. Med. Pr. 2016;67(1):89-96 Słowa kluczowe: arsen, trójtlenek arsenu, choroby nowotworowe, trucizna, lek, apoptoza Abstract Arsenic (As) is commonly known as a poison. Only a few people know that As has also been widely used in medicine. In the past years As and its compounds were used as a medicine for the treatment of such diseases as diabetes, psoriasis, syphilis, skin ulcers and joint diseases. Nowadays As is also used especially in the treatment of patients with acute promyelocytic leukemia. The International Agency for Research on Cancer (IARC) has recognized arsenic as an element with carcinogenic effect evidenced by epidemiological studies, but as previously mentioned it is also used in the treatment of neoplastic diseases. This underlines the specificity of the arsenic effects. Arsenic occurs widely in the natural environment, for example, it is present in soil and water, which contributes to its migration to food products. Long exposure to this element may lead to liver damages and also to changes in myocardium. Bearing in mind that such serious health problems can occur, monitoring of the As presence in the environmental media plays a very important role. In addition, the occupational risk of As exposure in the workplace should be identified and checked. Also the standards for As presence in food should be established. This paper presents a review of the 2015 publications based on the Medical database like PubMed and Polish Medical Bibliography. It in...

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“…All of these parameters considered as a highly indicators for kidney damage 24, 25 . Earlier studies showed that arsenic is a heavy metal ion and increases the production of Reactive Oxygen Species(ROS) concomitant with increases the production ofpro-inflammatory cytokines and increased activities of the oxidant enzymes such as heme oxygenase-1 (HO-1), cyclooxygenase-2 (COX-2) and Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 26, 27 Paralleled with these findings, kidney histopathological examination revealed a marked interstitial hemorrhage among renal tubules with thickening of lining epithelium of renal tubules and degeneration in proximal convoluted tubules and distal tubules 28 .…”

Section: Cmentioning

confidence: 99%

Spirulina platensis, reduced liver and kidney injuries induced by Sodium arsenite

2017

IJPTR

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: Spirulina platensis, a blue-green alga, has vastly therapeutic properties and it is used as food supplement. This study aims to evaluate the protective effect of Spirulina platensis against arsenic hepatorenal toxicity based on its antioxidantproperties,free-radical scavenger and immunological properties. Oral administration of sodium arsenite (6.3mg/Kg, p.o BW) to rats for eight weeks led to a significant increase in serum monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), cholesterol, triglycerides, liver (AST,ALT, and ALP), and kidney function parameters (urea, uric acid, and creatinine) except serum protein level which was significantly reduced. In addition, arsenic-induced oxidative stress and lipid peroxidation process as evidenced by elevation of malondialdehyde (MDA) and declinein the activities of hepatic and renal catalase (CAT),superoxide dismutase(SOD) enzymes, and glutathione (GSH) levels in which reflected on the final body and liver weights.Hepatorenal pathological changes were observed in the arsenic group.Treatment of rats with spirulina platensis(300mg/kg, p.o BW) mitigates indices of atherosclerosis, hepato-renal oxidative stress and pathological changes of liver and kidney induced by arsenic. These results support the spirulina protective effect of by which it lessens several factors involved in the progression of atherosclerosis and liver and kidney toxicity.

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Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats

Cited by 33 publications

References 72 publications

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Arsenic – Poison or medicine?

Spirulina platensis, reduced liver and kidney injuries induced by Sodium arsenite

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