GREEN TEA IN TRANSDERMAL FORMULATION: HPLC METHOD FOR QUALITY CONTROL AND<i>IN VITRO</i>DRUG RELEASE ASSAYS

Alves, Michele Campos; Almeida, Priscila Aparecida de; Polonini, Hudson; Raposo, Nádia Rezende Barbosa; Ferreira, Adriana; Brandão, Marcos Antônio Fernandes

doi:10.5935/0100-4042.20140117

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…More specifically, according to the studies found in the literature [62][63][64], four different fluids were tested, as reported in Table 4. The release behaviour of the pure green tea extract was determined utilising five Franz diffusion cells for 8 h. The release time was set based on the usage instructions of most of the topical creams available on the market.…”

Section: Preliminary Diffusion Studymentioning

confidence: 99%

A Preliminary Study on the Release of Bioactive Compounds from Rice Starch Hydrogels Produced by High-Pressure Processing (HPP)

D’Aniello,

Koshenaj,

Ferrari

2023

Gels

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This work aimed to carry out a preliminary study on the release of bioactive compounds loaded into starch-based hydrogels produced by high-pressure processing (HPP). As a study case, the experiments were carried out on rice starch HPP hydrogels. Rice starch (20% w/w) and green tea extract (2% w/w), suspended in distilled water, were treated by HPP at processing conditions enabling starch gelatinisation, namely 600 MPa for 15 min at room temperature. Additional experiments were carried out on samples that were further loaded with glycerol (5% w/w). Gel formation was assessed by analysing the gelatinisation extent, structuring level, and swelling power of the samples. At the processing conditions utilised, stable hydrogels were obtained even in the presence of the extract and/or the glycerol in the starch suspension. As expected, the colour of the hydrogels formed was affected by the addition of green tea extract in the starch solution. HPP starch hydrogels were characterised by Fourier transform infrared spectroscopy (FT-IR) to determine the interactions between the different compounds utilised in the formulation. Moreover, the release kinetics of bioactive compounds from HPP rice starch hydrogels was evaluated using a vertical Franz diffusion cells system, simulating a transdermal pattern. The diffusion of bioactive compounds was measured spectrophotometrically and via HPLC analysis. A controlled release of bioactive compounds from the hydrogel structure was detected, suggesting that small molecules, such as polyphenols, positively interacted with the rice starch HPP hydrogel network that allowed a smooth and constant release of these bioactive compounds over time.

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Section: Preliminary Diffusion Studymentioning

confidence: 99%

A Preliminary Study on the Release of Bioactive Compounds from Rice Starch Hydrogels Produced by High-Pressure Processing (HPP)

D’Aniello,

Koshenaj,

Ferrari

2023

Gels

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“…Tea is a widely used beverage in worldwide (Michele et al 2014;Setyawan et al 2018a, b;Shiyan et al 2019). Green tea has been reported to have antioxidant, antimutagenic, anticancer, antibacterial, antiobesity, antihypertensive, and antidiabetic properties (Batchelder et al 2004;Geetha et al 2004;Hsu 2005;Michele et al 2014;Shiyan et al 2020). Green tea contains many polyphenol compounds, such as catechins, which have been known to inhibit the process of initiation, promotion, and cancer progression (Bouzari et al 2009).…”

Section: Introductionmentioning

confidence: 99%

The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch

Setyawan¹,

Rohman²,

Setyowati³

et al. 2021

PHAR

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Aim: This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods: The transdermal matrix patch formulation was optimized by the simplex lattice design method. The correlation between responses was analyzed using chemometrics. The observed responses were: 1. the physical properties of the matrix patch, and 2. the percentage of dissolution efficiency of catechins, caffeine, and epigallocatechin gallate released from the patch. The determination of drug release kinetics was based on the curve-fitting analysis using zero-order, first-order, Higuchi, and Korsmeyer-Peppas models. Results: The results showed that the optimal formula was obtained using the mixture of HPMC K100, HPMC K4M, and PEG 400 at a ratio of 4.0: 4.5: 0.5. The principal component analysis (PCA) showed that %DE300 values of catechin caffeine and epigallocatechin gallate positively correlate. A similar condition was observed between the weight and thickness of the matrix. Drug release kinetics follows the Korsmeyer-Peppas model.

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Quantitative analysis, in vitro and in vivo permeability assays of toxic alkaloids in Qingpeng ointment using ultra performance liquid chromatography coupled with tandem mass spectrometry

Chen

2021

Journal of Liquid Chromatography & Related Technologies

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GREEN TEA IN TRANSDERMAL FORMULATION: HPLC METHOD FOR QUALITY CONTROL ANDIN VITRODRUG RELEASE ASSAYS

Cited by 4 publications

References 29 publications

A Preliminary Study on the Release of Bioactive Compounds from Rice Starch Hydrogels Produced by High-Pressure Processing (HPP)

A Preliminary Study on the Release of Bioactive Compounds from Rice Starch Hydrogels Produced by High-Pressure Processing (HPP)

The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch

Quantitative analysis, in vitro and in vivo permeability assays of toxic alkaloids in Qingpeng ointment using ultra performance liquid chromatography coupled with tandem mass spectrometry

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