Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass

Funamoto, Masaki; Masumoto, Hidetoshi; Takaori, Koji; Taki, Tomofumi; Setozaki, Shuji; Yamazaki, Kazuhiro; Minakata, Kenji; Ikeda, Tadashi; Hyon, Suong‐Hyu; Sakata, Ryuzo

doi:10.1016/j.athoracsur.2015.09.080

Cited by 24 publications

(23 citation statements)

References 26 publications

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“…The mechanical-ventilation settings were similar to those in a previous study [8]; the only difference was the inspired gas. Because we used room air instead of higher inspired oxygen fraction as the inspired gas, the levels of blood gases (PaO 2 and PaCO 2 ) in our study were lower than those reported in previous studies [9–12]. However, the blood gas levels in the CA + ECLS and NC + ECLS groups did not exhibit any differences at the same time points in our study.…”

Section: Discussioncontrasting

confidence: 54%

“…Despite the decrease in hematocrit caused by hemodilution, sufficient oxygenation was maintained in both groups. Animal models have been reported to maintain adequate oxygen delivery to satisfy the whole body’s oxygen demands without blood product administration when the ventilator was supplied with higher inspired oxygen fraction [10, 12, 16–18]. However, we ventilated only with room air even in the absence of a blood transfusion to maintain acceptable oxygenation.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model

Chang

Luo

et al. 2017

BMC Cardiovasc Disord

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BackgroundExtracorporeal life support (ECLS) systems are life-saving devices used for treating patients with severe cardiopulmonary failure. In this study, we implemented a rat model of ECLS without the administration of inotropes or vasopressors.MethodsThe rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min. The right external jugular vein and right femoral artery were separately cannulated to the ECLS outflow and inflow, respectively. Thereafter, ECLS was terminated, wounds were closed, and mechanical ventilation was provided for another 90 min. Subsequently, blood gas and hemodynamic analyses were performed. The plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) were measured 120 min after reperfusion.ResultsThe metabolic rate of lactate in the group of asphyxial cardiac arrest rescued by ECLS was slow; therefore, the pH at 120 min after reperfusion was significantly lower in this group than that in the group of normal rats treated with ECLS. The hemodynamic data showed no between-group differences. The plasma levels of CRP, IL-6, IL-10, and TNF-α increased after ECLS treatment.ConclusionsWe successfully established a rodent ECLS model, which might be a useful approach for studying the pathophysiology induced by ECLS under clinical conditions.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-017-0558-6) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model

Chang

Luo

et al. 2017

BMC Cardiovasc Disord

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“…CPB was performed using a surgical technique as previously described in our laboratory with some modifications (Video 1). 20,21 The right femoral artery was cannulated with a 24-gauge intravenous catheter (SURFLO ETFE I.V. Catheter; Terumo, Tokyo, Japan) to monitor systemic arterial pressure and to analyze arterial blood gas (epoc Blood Analysis System; Alere Medical Co, Tokyo, Japan).…”

Section: Surgical Proceduresmentioning

confidence: 99%

Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model

Hirao

Minakata

Masumoto

et al. 2017

The Journal of Thoracic and Cardiovascular Surgery

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Background: Cardiopulmonary bypass (CPB) may induce systemic inflammatory responses causing acute lung injury. Recombinant human soluble thrombomodulin (rTM) is reported to attenuate the secretion of inflammatory cytokines and the high-mobility group box 1 (HMGB1) protein, which is critical in controlling systemic inflammation and apoptosis. We investigated the protective effects of rTM on CPB-induced lung injury in a rat model. Methods: Eighteen male Sprague-Dawley rats were divided into 3 groups: sham, control (CPB alone), and rTM (CPB þ rTM). CPB was conducted in the control group and the rTM group. A bolus of rTM (3 mg/kg) was administered to the rTM group rats before CPB establishment. Results: The ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen only dropped markedly from before CPB in the control group (P<.001). Serum tumor necrosis factor a, interleukin (IL) 6, and HMGB1 levels were significantly higher in the control group after CPB. Pathologic study revealed significantly more severe congestion, alveolar hemorrhage, neutrophil accumulation, and edema, and the number of lung cells expressing HMGB1 increased in the control group. The mRNA expression levels of tumor necrosis factor a, IL-6, IL-1b, and HMGB1 in the control group were significantly higher than those in other groups. According to Western blot analysis, nuclear factor-kB p65 in lung tissue was significantly downregulated in the rTM group. The number of apoptotic cells and the protein of cleaved Caspase-3 were reduced in the rTM group. Conclusions: These results suggest that rTM prevents acute lung injury through attenuating inflammation and apoptosis during and after CPB in a rat model. (

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“…Our working group examined the influence of CPB and EGCG on hippocampi of piglets and we could show that pericellular edema, transcription factors like HIF1α or AIF, as well as cleaved caspase 3 were significantly attenuated in the EGCG group [91]. Also, other organs like kidney and lung profited from EGCG [97,98,99]. However, EGCG has not yet been tested in a clinical setting of CPB.…”

Section: Pharmacological Methods For Brain Protectionmentioning

confidence: 99%

Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass

Salameh

Dhein

Dähnert

et al. 2016

IJMS

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Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain.

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Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass

Cited by 24 publications

References 26 publications

Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model

Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model

Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model

Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass

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