Green tea polyphenols as a natural tumour cell proteasome inhibitor

Dou, Q. Ping; Landis-Piwowar, Kristin R.; Chen, D.; Huo, Congde; Wan, Shengbiao; Chan, Tak Hang

doi:10.1007/s10787-008-8017-8

Cited by 40 publications

(35 citation statements)

References 24 publications

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“…3) which are metabolites or potential metabolites of tea catechins in biomethylation [123]. It was found that the addition of a methyl group on the B- or D-ring of (−)-EGCG or (−)-ECG led to decreased proteasome inhibition and, as the number of methyl groups increased, the inhibitory potencies further decreased [124]. Metabolic O-methylation of EGCG may indeed reduce the effectiveness of EGCG as it relates to its anticancer activity [125], lending support of the human study [122].…”

Section: Tea Polyphenol Derivatives In Cancer Studiesmentioning

confidence: 99%

EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

Chen

Wan

Yang

et al. 2011

Advances in Clinical Chemistry

188

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Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure–activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.

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Section: Tea Polyphenol Derivatives In Cancer Studiesmentioning

confidence: 99%

EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

Chen

Wan

Yang

et al. 2011

Advances in Clinical Chemistry

188

View full text Add to dashboard Cite

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“…A number of studies have demonstrated the proteasome inhibitory effects of green tea polyphenol EGCG and its related analogs [110,111] and these observations led to the exploration of their potential against F-BOX family members and also for their muscle atrophy preventive mechanisms of action. This becomes especially relevant given that EGCG is capable of down-regulating SKP2 in breast cancer cell lines indicating that it can impact E-3 ubiquitin ligases [112].…”

Section: Natural Products Targeting F-box Family Proteins and Theimentioning

confidence: 99%

F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities

Sukari

Muqbil

Mohammad

et al. 2016

Seminars in Cancer Biology

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Cancer cachexia is a debilitating metabolic syndrome accounting for fatigue, an impairment of normal activities, loss of muscle mass associated with body weight loss eventually leading to death in majority of patients with advanced disease. Cachexia patients undergoing skeletal muscle atrophy show consistent activation of the SCF ubiquitin ligase (F-BOX) family member Atrogin-1 (also known as MAFBx/FBXO32) alongside the activation of the muscle ring finger protein1 (MuRF1). Other lesser known F-BOX family members are also emerging as key players supporting muscle wasting pathways. Recent work highlights a spectrum of different cancer signaling mechanisms impacting F-BOX family members that feed forward muscle atrophy related genes during cachexia. These novel players provide unique opportunities to block cachexia induced skeletal muscle atrophy by therapeutically targeting the SCF protein ligases. Conversely, strategies that induce the production of proteins may be helpful to counter the effects of these F-BOX proteins. Through this review, we bring forward some novel targets that promote atrogin-1 signaling in cachexia and muscle wasting and highlight newer therapeutic opportunities that can help in the better management of patients with this devastating and fatal disorder.

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“…General protease activity and activity associated with a chymotrypsin-like protease from the proteasome were affected. EGCG was again one of the more effective analogues, and its known interaction with the proteasome (Lam et al, 2004;Dou et al, 2008;Dou, 2009) and the possible role of the proteasome in nematode development and oogenesis (Pispa et al, 2008) make the EGCG-proteasome interaction of continuing interest.…”

Section: Forum Article: Internal Processes O F Plant-parasitic Nematodesmentioning

confidence: 99%

Targeting internal processes of plant-parasitic nematodes in the pursuit of novel agents for their control

Masler

2014

Nematol

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The success of plant-parasitic nematodes as competitors with humans for crops is evidenced by the parasites' significant and continuous economic drain on global agriculture. Scientific efforts dedicated to the control of plant-parasitic nematodes employ strategies from the environmental to molecular levels. Understanding the interaction of the nematode with its environment, and the molecules involved, offers great promise for novel control agent development. Perhaps more significantly, such knowledge facilitates the generation of ever more detailed and sophisticated information on nematode biology and new molecular targets. Among the most economically important groups of plant-parasitic nematodes are those comprising the cyst-forming species and the root-knot nematodes. Presented here is a brief overview of research into the biology of these parasites relative to their life cycles. Recent advances in elucidating the molecular biology and biochemistry of nematode-plant interactions during the internal parasitic stages of the life cycle have been driven by advances in genomics and transcriptomics. The remarkable discoveries regarding parasitism, and the application of genetic resources in these findings, provide a template for advanced investigation of external, survival stages biology. While survival biology research lags somewhat behind that of parasitism with regard to the molecular genetics of signalling and response, its extensive catalogue promises explosive rates of discovery as progress in genomics and transcriptomics allows a molecular genetic examination of embryogenesis, dormancy and hatching. Our group is interested in behaviour, development and hatching of cyst and root-knot nematodes, and the effects of the environment on the mechanisms of these activities. Phytochemical and temperature effects are discussed, and evidence is presented that the cyst may provide useful molecules for exploring nematode physiology.

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Green tea polyphenols as a natural tumour cell proteasome inhibitor

Cited by 40 publications

References 24 publications

EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities

Targeting internal processes of plant-parasitic nematodes in the pursuit of novel agents for their control

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