Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice

Chen, Gang; Tan, Ming‐Liang; Li, Kai-Kai; Leung, Ping‐Chung; Ko, Chun‐Hay

doi:10.1016/j.jep.2015.08.043

Cited by 101 publications

(78 citation statements)

References 28 publications

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“…Hyperuricemia in the mice was induced by PO (280 mg/kg) as previously described. [20,21] The mice were divided into 6 groups randomly (n = 6 each): the normal control group (NC), model control group (MC), 10 mg/kg AP group, OSE high dose (2000 mg/kg) group (OSH), OSE medium dose (1000 mg/kg) group (OSM) and OSE low dose (500 mg/kg) group (OSL), and were orally administered with PO 0.5% CMC-Na (vehicle), AP (positive control drug) and OSE (500, 1000 and 2000 mg/ kg) for seven consecutive days (at 8:00-9:00 a.m.). AP and OSE were dispersed in 0.5% CMC-Na and were intragastrically administered to the mice 1 h after PO administration.…”

Section: Animals Hyperuricemia Induction and Experimental Designmentioning

confidence: 99%

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice

Wang

Sun³

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives To investigate the antihyperuricemia and nephroprotective effects of Orthosiphon stamineus extracts on hyperuricemia (HUA) mice and explore the potential mechanisms. Methods Orthosiphon stamineus extracts were extracted using 50% ethanol and enriched using ethyl acetate, and characterised utilising UPLC/ESI‐MS. A potassium oxonate (PO) induced hyperuricemic mouse model was used to evaluate antihyperuricemia and nephroprotective effects of O. stamineus ethyl acetate extracts (OSE). Key findings Eight constituents from OSE were identified and OSE treatment ameliorated HUA by regulating key indicators of kidney dysfunction and xanthine oxidase, adenosine deaminase activity and urate transporters in hyperuricemic mice. Moreover, in renal histopathology analysis, OSE significantly alleviated kidney injury. Conclusions These findings demonstrate that OSE has antihyperuricemic and nephroprotective effects on PO‐induced HUA mice and those results indicate that OSE could be a safe and effective agent or functional ingredient for treating HUA.

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Section: Animals Hyperuricemia Induction and Experimental Designmentioning

confidence: 99%

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice

Wang

Sun³

et al. 2020

Journal of Pharmacy and Pharmacology

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“…[108]. В опытах на мышах с индуцированной оксонатом калия гиперурикемией вы-явлено, что, помимо подавления активности ксантинокси-дазы, полифенолы зеленого чая способны положительно влиять на экскрецию почками МК, снижая экспрессию URAT1 и увеличивая содержание OAT1 и OAT3 [109].…”

Section: мясо и морепродук тыunclassified

Diet in Gout and Hyperuricemia

Желябина¹,

Елисеев²

2017

Naučno-praktičeskaâ revmatologiâ

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The paper reviews the most important works devoted to the study of the impact of individual foods and food components on the risk of gout, its clinical manifestations and the level of uricemia. It considers some mechanisms probably underlying the impact of dietary patterns on the level of uricemia. It is shown that the available data on possible alterations in the diet with their proper application can considerably affect both the incidence of gout and the course of the current disease.

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“…In one study to investigate the effect of GTP on SUA level, it was found that GTP significantly decreased SUA levels in a dose dependent manner in potassium oxonate-induced hyperuricemic mice. Furthermore, GTP reduced XOD expression in liver and reduced URAT1 expression and increased OAT1 and OAT3 expressions in kidneys, suggesting that GTP might attenuate SUA level through decreasing production and increasing excretion of uric acid [22]. Hu et al found Jasminoidin significantly lowered the SUA levels and increased the uric acid excretion.…”

Section: Natural Products For Improving Hyperuricemiamentioning

confidence: 99%

Natural Products Improving Hyperuricemia with Hepatorenal Dual Effects

Hao

Zhang

Song

2016

Evidence-Based Complementary and Alternative Medicine

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This review aims to put forth an overview of natural products reducing uric acid level with hepatorenal dual effects. The prevalence of hyperuricemia increased rapidly in recent years and has closely interdependent relationship with other metabolic disorders. Current therapeutically used drugs including a few uricostatic and uricosuric chemical drugs are proved efficient to control serum uric acid level. However, their side effects as well as contraindication in some cases with liver, kidney injury, or other conditions frequently limit their clinic application. More attention thus has been paid to natural products as an alternative means in treating hyperuricemia. Many natural products have been proved efficient in downregulating uric acid level, among which some can improve hyperuricemia with hepatorenal dual effects. It means these natural products can regulate both the production and the excretion of uric acid by targeting the key metabolic enzymes mainly in liver or uric acid transporters in kidneys. Thus, these natural products could have stronger efficacy and broader application, which may be developed for the treatment of hyperuricemia in clinic.

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Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice

Cited by 101 publications

References 28 publications

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice

Diet in Gout and Hyperuricemia

Natural Products Improving Hyperuricemia with Hepatorenal Dual Effects

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