Green Tea Polyphenols Mitigate Gliadin‐Mediated Inflammation and Permeability in Vitro

Buiten, Charlene B. Van; Lambert, Joshua D.; Elias, Ryan J.

doi:10.1002/mnfr.201700879

Cited by 45 publications

(40 citation statements)

References 41 publications

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“…Within the category of flavonoids, anthocyanidins, flavan-3-ols and flavonols were the most studied in relation to their binding capacity to gluten proteins [ 26 , 27 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 38 ] ( Table 1 ). The interaction of gluten and its individual fractions with anthocyans was studied mainly by spectroscopic techniques, including ultraviolet–visible (UV-Vis), nuclear magnetic resonance (NMR), infrared (IR) and Raman spectroscopy [ 31 , 32 , 34 , 35 ].…”

Section: Polyphenols-gluten Interaction: Sequestering Of Celiac-rementioning

confidence: 99%

“…This knowledge about the pathogenesis of celiac disease allows different therapeutic approaches or approaches aimed at controlling or modulating certain processes ( Figure 2 ). A green tea extract containing mostly EGCG, inhibited pepsin/trypsin-mediated digestion of gliadins in vitro [ 36 ]. Moreover, enzyme activity assays showed that green tea extract was also able to inhibit pepsin and trypsin activity in a dose-dependent manner.…”

Section: Potential Translational Effects For Celiac Diseasementioning

confidence: 99%

“…Moreover, enzyme activity assays showed that green tea extract was also able to inhibit pepsin and trypsin activity in a dose-dependent manner. The authors hypothesized that the inhibition of gliadin digestion can be the result of the physical interaction between green tea extract and gliadins, decreasing gliadins digestibility, the result of direct inhibition of the digestive enzymes or by a combination of these mechanisms [ 36 ]. On the other hand, it was demonstrated that EGCG interacts with the proteolytic-resistant and immunodominant peptide 33-mer at a range of pH associated with digestion [ 37 ].…”

Section: Potential Translational Effects For Celiac Diseasementioning

confidence: 99%

“…First, the treatment with green tea extract did not exert any significant effect on cell viability, but inhibited gliadin-mediated permeability on Caco-2 cells as transepithelial electrical resistance (TEER) was preserved. Noteworthy, the secretion of proinflammatory cytokines (IL-6 and IL-8) stimulated by the presence of peptic/tryptic digests of gliadin was also mediated by the green tea extract, a protective effect that was sustained over 24 h [ 36 ]. Like EGCG, tannins like procyanidin B3 and the trimer C2 also showed the ability to reduce 32-mer transepithelial transport; trimer C2 treatment reduced about 99% the concentration of 32-mer peptide in the basolateral compartment.…”

Section: Potential Translational Effects For Celiac Diseasementioning

confidence: 99%

“…This interaction of gluten proteins and some peptides with a pivotal role in the disease pathogenesis with some polyphenols is being recently and continuously studied. Some important results have already been reported regarding the interaction and potential translational effects for celiac disease [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Review of Structural Features and Binding Capacity of Polyphenols to Gluten Proteins and Peptides In Vitro: Relevance to Celiac Disease

et al. 2020

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Polyphenols have been extensively studied due to their beneficial effects on human health, particularly for the prevention and treatment of diseases related to oxidative stress. Nevertheless, they are also known to have an anti-nutritional effect in relation to protein metabolism. This effect is a consequence of its binding to digestive enzymes and/or protein substrates. Dietary gluten is the main trigger of celiac disease, a common immune-based disease of the small intestine and for which the only treatment available is the adherence to a gluten-free diet. Recent studies have addressed the use of dietary polyphenols to interact with gluten proteins and avoid its downstream deleterious effects, taking the advantage of the anti-nutritive nature of polyphenols by protein sequestering. Flavonoids, coumarins and tannins have shown the ability to form insoluble complexes with gluten proteins. One of the most promising molecules has been epigallocatechin-3-gallate, which through its binding to gliadins, was able to reduce gliadins digestibility and its ability to stimulate monolayer permeability and transepithelial transport of immunodominant peptides in cell models. This review focuses on the structural features and binding capacity of polyphenols to gluten proteins and peptides, and the prospects of developing an adjuvant therapy in celiac disease.

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Section: Polyphenols-gluten Interaction: Sequestering Of Celiac-rementioning

confidence: 99%

Section: Potential Translational Effects For Celiac Diseasementioning

confidence: 99%

Section: Potential Translational Effects For Celiac Diseasementioning

confidence: 99%

Section: Potential Translational Effects For Celiac Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Review of Structural Features and Binding Capacity of Polyphenols to Gluten Proteins and Peptides In Vitro: Relevance to Celiac Disease

et al. 2020

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Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

et al. 2021

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The intestinal epithelium acts as a key defensive barrier that protects internal organs from the detrimental gut environment. The homeostasis of the gut epithelium may be altered by environmental conditions and exogenous pathogens that can impair the integrity of the gut barrier, leading to immune response associated with low‐grade systemic inflammation, a known contributor to metabolic and inflammatory diseases. Autoimmune diseases (ADs) are a collection of abnormalities of the immune system, in which the immune system of an individual acts against healthy organs or systems, due to a failure in antigenic recognition. Hence, this review aims to focus on modulators of intestinal epithelial barrier dysfunction with effects on autoimmune disorders. All data on dietary phytochemicals and their impact on the modulation of the intestinal epithelium barrier and various ADs were collected from electronic searches of library databases (PubMed, Science Direct, and Google Scholar). An electronic search was conducted using PubMed, Science Direct, and Google Scholar by finding the keywords “phytochemicals” AND “bioactive compounds” AND “flavonoids” AND “polyphenols” OR “intestinal epithelium barrier” OR “autoimmune diseases” OR “inflammatory diseases” in “Title/Abstract/Keywords,” with the date from January 2011 to December 2020, to identify all published studies (in vitro, in vivo, clinical, and case‐control) that have investigated the connection between dietary phytochemicals and their various beneficial effects. Dietary phytochemicals are promising key modulators, stabilizing the integrity of the intestinal barrier and attenuating the progression of ADs. Health‐modulatory information was gathered and orchestrated in a suitable place in this review.

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Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Liang

Saunders

Sanossian

2023

Food Science & Nutrition

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Dysfunction of gut barrier is known as “leaky gut” or increased intestinal permeability. Numerous recent scientific evidences showed the association between gut dysfunction and multiple gastrointestinal tract (GI) and non‐GI diseases. Research also demonstrated that food plays a crucial role to cause or remedy gut dysfunction related to diseases. We reviewed recent articles from electronic databases, mainly PubMed. The data were based on animal models, cell models, and human research in vivo and in vitro models. In this comprehensive review, our aim focused on the relationship between dietary factors, intestinal permeability dysfunction, and related diseases. This review synthesizes currently available literature and is discussed in three parts: (a) the mechanism of gut barrier and function, (b) food and dietary supplements that may promote gut health, and food or medication that may alter gut function, and (c) a table that organizes the synthesized information by general mechanisms for diseases related to leaky gut/intestinal permeability and associated dietary influences. With future research, dietary intervention could be a new target for individualized disease prevention and management.

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Green Tea Polyphenols Mitigate Gliadin‐Mediated Inflammation and Permeability in Vitro

Abstract: There are potential beneficial effects of GTE as an adjuvant therapy for celiac disease through direct interaction between gliadin proteins and green tea polyphenols.

Cited by 45 publications

References 41 publications

Review of Structural Features and Binding Capacity of Polyphenols to Gluten Proteins and Peptides In Vitro: Relevance to Celiac Disease

Review of Structural Features and Binding Capacity of Polyphenols to Gluten Proteins and Peptides In Vitro: Relevance to Celiac Disease

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

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