Green Tropical Phytoextracts - Promising Anticancer Alternative

Khan, Abid Ali; Omer, Kosar Ali; Talib, Ayesha; Ahmed, Haroon; Javed, Mohamad Arshad; Sarmidi, Roji Mohamad

doi:10.1590/1678-4324-2016160062

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…A study showed the presence of polyphenols and flavonoids such as genistin, alkaloids, and tannins. [ 9 ] A recent published report by Kumari and Dhanalekshmi[ 10 ] also confirmed the presence of phenols, flavonoids, tannins, and saponins in F. deltoidea leaf, stem, and fruit extract. Harun and Musapha[ 11 ] reported the tannins, phlobatannins, flavonoids, saponins, steroids, terpenoids, cardiac glycosides, alkaloids, anthraquinones, and polyphenol in F. deltoidea var.…”

Section: P Hytochemical a Nalysis Of F Icus Deltoideamentioning

confidence: 70%

“…[ 22 ] However, aqueous leaf extract of F. deltoidea has shown less cytotoxicity effect. Khan et al [ 9 ] also investigated cytotoxicity effect of water extract of F. deltoidea leaves on prostate cancer cells and found poor activity. Soib[ 23 ] reported the antiproliferative activity at different concentrations of extract of F. deltoidea after 48h against prostate cancer cell line (DU145).…”

Section: P Harmacological P Roperties Of F Icus Deltoideamentioning

confidence: 99%

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An Overview of Phytochemical and Biological Activities

Ashraf

Haque²,

Amir

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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A BSTRACT Ficus deltoidea Jack (Moraceae) is a well-known medicinal plant used in customary medication among the Malay people to reduce and mend sicknesses such as ulcers, psoriasis, cytotoxicity, cardioprotective, inflammation, jaundice, vitiligo, hemorrhage, diabetes, convulsion, hepatitis, dysentery injuries, wounds, and stiffness. Ficus deltoidea contains a wide variety of bioactive compounds from different phytochemical groups such as alkaloids, phenols, flavonoids, saponins, sterols, terpenes, carbohydrates, and proteins. The genus Ficus has several hundreds of species, which shows excellent therapeutic effects and a wide variety of helpful properties for human welfare. Searching information was collected by using electronic databases including Web of Science, Science Direct, Springer, SciFinder, PubMed, Scopus, Medline, Embase, and Google Scholar. This review is, therefore, an effort to give a detailed survey of the literature on its pharmacognosy, phytochemistry, phytochemical, and pharmacological properties of Ficus and its important species. This summary could be beneficial for future research aiming to exploit the therapeutic potential of Ficus and its useful medicinal species.

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Section: P Hytochemical a Nalysis Of F Icus Deltoideamentioning

confidence: 70%

Section: P Harmacological P Roperties Of F Icus Deltoideamentioning

confidence: 99%

An Overview of Phytochemical and Biological Activities

Ashraf

Haque²,

Amir

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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“…Natural extracts have been studies as potential mitigators of prostatic disorders, showing anticancer, antiproliferative, antiapoptotic properties [23,24]. The Jaboticaba (MYRTACEAE Myrciaria jaboticaba (Vell.)…”

Section: Introductionmentioning

confidence: 99%

Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.

Longo

Lamas

Rossetto

et al. 2023

Braz. arch. biol. technol.

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The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and westernblotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. HIGHLIGHTS• Brazilian berry mitigate the disorder onset in prostate of senile/high-fat mice.• Brazilian berry reduced AR/ERα/IGFR-1 labeling in prostate of senile/high-fat mice.• Brazilian berry preventive effect increases according to the prostatic damages rise.

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“…Labisia pumila is a herbaceous plant with creeping stem which belongs to Myrsinaceae family ( 12 ) is known by the locals as Kacip Fatimah and Selusuh Fatimah . In Malaysia, there are three varieties: L. pumila var .…”

Section: Introductionmentioning

confidence: 99%

An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models

Mohammad

Mdm

et al. 2018

MJMS

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Osteoporosis is considered a silent disease, the early symptoms of which often go unrecognised. Osteoporosis causes bone loss, reduces mineralised density, and inevitably leads to bone fracture. Hormonal deficiencies due to aging or drug induction are also frequently attributed to osteoporosis. Nevertheless, the phytochemical content of natural plants has been proven to significantly reduce osteoporotic conditions. A systematic review was conducted by this study to identify research specifically on the effects of Malaysian herbs such as Piper sarmentosum, Eurycoma longifolia and Labisia pumila on osteoporotic bone changes. This review consisted of a comprehensive search of five databases for the effects of specific herbs on osteoporotic bone change. These databases were Web of Science (WOS), Medline, Scopus, ScienceDirect and PubMed. The articles were selected throughout the years, were limited to the English language and fully documented. Duplication, irrelevant titles, different herbs and in vitro studies were excluded, including those that are not original research papers. A total of 399 potential studies were identified, but only 21 samples were accepted based on the inclusion and exclusion criteria. Six of the twenty one studies were on Piper sarmentosum, six on Eurycoma longifolia, and the remaining nine studies were on Labisia pumila. Overall, in three of the studies a glucocorticoid-induced model was used, while in 12 of the studies an ovariectomised model was used, and for the other six studies an orchidectomised model was used as the osteoporotic model. All of the studies reported varied results based on the type of herbs used, but in comparison to Eurycoma longifolia, Piper sarmentosum and Labisia pumila recorded better anti-osteoporotic effects, while the majority of studies on Eurycoma longifolia were unable to preserve bone strength.

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Green Tropical Phytoextracts - Promising Anticancer Alternative

Abstract: The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and

Cited by 5 publications

References 34 publications

An Overview of Phytochemical and Biological Activities

An Overview of Phytochemical and Biological Activities

Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.

An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models

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