Greener extraction process and enhanced in vivo bioavailability of bioactive components from Carthamus tinctorius L. by natural deep eutectic solvents

Tong, Xiuzhen; Yang, Jiehong; Yu, Zhao; Wan, Haofang; He, Yu; Zhang, Ling; Chang, Lijie

doi:10.1016/j.foodchem.2021.129090

Cited by 45 publications

(31 citation statements)

References 36 publications

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“…It is noteworthy that the rats administrated with NaDES extracts were observed in normal situations without any symptoms of toxicosis. Together with our work on chalcone derivatives from Carthamus tinctoriu [12] and a previous report on berberine [25], the present study might provide a new beneficial property of NaDES, and the capacity to enhance the oral bioavailability of compounds. Especially, this might be useful for naturally occurring nutrients such as resveratrol and curcumin, the clinical applications of which were greatly hindered by their poor bioavailabilities.…”

Section: Discussionsupporting

confidence: 68%

“…For instance, Wang et al developed a highly efficient enzymatic hydrolysis reaction to convert rutin to isoquercitrin and L-rhamnose [11]. In our study, the oral bioavailabilities of hydroxysafflor yellow A and anhydrosafflor yellow B were greatly improved in the NaDES media [12].…”

Section: Introductionmentioning

confidence: 54%

“…Accumulating research has indicated that NaDESs have broader functions other than the improvement of the extraction efficiency. Inspired by the previous work that NaDES enhanced the bioavailability of berberine [25], hydroxysafflower yellow A and anhydrosafflor yellow B [12], we next investigated the in vivo pharmacokinetics of NaDES and aqueous extracts of PR comparatively. The content of PUE is more than 10-fold higher than that of 3-MPR and PRX; therefore, only the plasma concentrations of PUE were measured.…”

Section: Hplc-ms/ms Methods Validationmentioning

confidence: 99%

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Screening, Optimization, and Bioavailability Research of Natural Deep Eutectic Solvent Extracts from Radix Pueraria

Huang

Yang

et al. 2021

Molecules

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Natural deep eutectic solvent (NaDES) is generally considered as a greener alternative to fossil solvent, with great potential in various areas. In the present work, 25 different NaDESs were screened for the extraction of puerarin (PUE) and its two natural derivatives from Radix Pueraria (RP). As the main isoflavone in RP, PUE has a wide range of biological activities. However, its application is restricted due to its poor solubility in water and low oral bioavailability. In this study, the extraction of PUE with NaDESs showed significant advantages compared with traditional solvents. While using L-Pro-Maa (L-proline-malic acid) under optimal conditions, the optimized yields of PUE, 3-MPR and PRX were 98.7 mg/g, 16.3 mg/g and 9.9 mg/g, respectively, which were 2.2-, 2.9- and 3.4-fold higher than that of water. Furthermore, the oral bioavailability of PUE in NaDES extracts was comparatively investigated in rats with HPLC-MS technique. Pharmacokinetic analysis revealed that the relative bioavailability of PUE in L-Pro-Maa extract is 323%. The result indicated that NaDES is not only a sustainable ionic liquid with higher extraction efficiency, but also an enhancer of oral bioavailability of specific natural products.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 54%

Section: Hplc-ms/ms Methods Validationmentioning

confidence: 99%

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Screening, Optimization, and Bioavailability Research of Natural Deep Eutectic Solvent Extracts from Radix Pueraria

Huang

Yang

et al. 2021

Molecules

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“…Plasma levels of the compounds in male Sprague-Dawley rats was increased after oral administration at a dose of 2 g extract/kg compared to an aqueous extract suspension. This indicates that HSYA and ASYB were promptly absorbed and then eliminated in 12 h [64].…”

Section: Bioavailability Of Compounds In Nadesmentioning

confidence: 87%

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Lusiana

Ramadon

Jantan

et al. 2021

Plants

112

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Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.

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“…As NADES species exhibit a superior solubilizing ability for NPs, this provides a special advantage for NADESs as extraction media. Examples in the extraction capabilities of NADESs for a large number of natural products are covered in a pair of excellent recent reviews [23], and more recent references [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Promising Technological and Industrial Applications of Deep Eutectic Systems

et al. 2021

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Deep Eutectic Systems (DESs) are obtained by combining Hydrogen Bond Acceptors (HBAs) and Hydrogen Bond Donors (HBDs) in specific molar ratios. Since their first appearance in the literature in 2003, they have shown a wide range of applications, ranging from the selective extraction of biomass or metals to medicine, as well as from pollution control systems to catalytic active solvents and co-solvents. The very peculiar physical properties of DESs, such as the elevated density and viscosity, reduced conductivity, improved solvent ability and a peculiar optical behavior, can be exploited for engineering modular systems which cannot be obtained with other non-eutectic mixtures. In the present review, selected DESs research fields, as their use in materials synthesis, as solvents for volatile organic compounds, as ingredients in pharmaceutical formulations and as active solvents and cosolvents in organic synthesis, are reported and discussed in terms of application and future perspectives.

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Greener extraction process and enhanced in vivo bioavailability of bioactive components from Carthamus tinctorius L. by natural deep eutectic solvents

Cited by 45 publications

References 36 publications

Screening, Optimization, and Bioavailability Research of Natural Deep Eutectic Solvent Extracts from Radix Pueraria

Screening, Optimization, and Bioavailability Research of Natural Deep Eutectic Solvent Extracts from Radix Pueraria

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Promising Technological and Industrial Applications of Deep Eutectic Systems

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