Greither's disease: a case report

A novel mutation resulting in keratin 1–linked palmoplantar keratoderma with epidermolytic ichthyosis

“…Although the etiology of Greither's disease is not fully elucidated, several authors have proposed that defects in the keratin 1 gene (KRT1) may be an important pathophysiologic component of this disease. 2 , 3 , 4 , 5 In this report, we describe a case of keratin 1–linked palmoplantar keratoderma with epidermolytic ichthyosis in which a previously unreported mutation in KRT1 was discovered. Although we favor classifying PPKs according to genetic testing, we recognize that this case could also be described as Greither's disease, using the historical eponymous naming system based on morphology and associated features.…”

A case of Greither’s disease with late onset of disease: a rare presentation

“…wierzchni zgięciowych nadgarstków (progrediens) i okolicy ścięgna Achillesa [5]. Na skórze w okolicy stawów kolanowych i łokciowych mogą występować hiperkeratotyczne blaszki.…”

“…This was followed by a few case reports of the same entity by the name of transgrediens et progrediens in the literature [2][3][4]. Non-epidermolytic palmoplantar keratoderma (PPK) with erythematous border extending to the dorsum (transgrediens) and the involvement of wrist flexures (progrediens) and tendon of Achilles are the salient morphological characteristics of the disease [5]. Hyperkeratotic plaques can be present on knees and elbows.…”

Transgrediens et progrediens palmoplantar keratoderma: a case of Greither’s disease

“…Clinical features include non-epidermolytic diffuse keratoderma of palms and soles with erythematous border and extension to the dorsal aspect (transgrediens) and the flexural aspect of the wrist (progrediens) and characteristic involvement of the Achilles tendon [5]. Hyperkeratotic plaques are seen on the knees and elbows and sometimes in the flexural areas as well.…”