Grewia Gum 1: Some Mechanical and Swelling Properties of Compact and Film

Nep, Elijah I.; Conway, Barbara R.

doi:10.4314/tjpr.v10i4.3

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…The swelling index for formulations MTF2 to MTF6 increased progressively until the 12th hour when there was a decline except for formulations MTF3 and MTF4. The control showed a progressive increase in swelling index even at 12 h. Polymer m containing gum that have long swelling time will have their medicaments released relatively slow [24]. Matrix tablets upon contact with water, hydrates, swells, and gels.…”

Section: Drug-excipient Compatibility Studiesmentioning

confidence: 99%

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Design and in Vitro Evaluation of Sustained Release Matrix Tablets of Metformin Produced Using Detarium Microcarpum Gum

2020

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Objective: The objective of this study was to evaluate sustained release matrix tablets of metformin formulated using Detarium microcarpum gum (DMG) as the matrix polymer. Methods: DMG was produced by acetone desolvation of the filtrate obtained by maceration of powdered seeds of Detarium microcarpum in distilled water. Metformin matrix tablets were prepared by direct compression technique using DMG or sodium carboxymethylcellulose (NaCMC) alone, or their combinations as the polymer matrix. The tablets were evaluated for hardness, friability, weight uniformity, drug content, swelling behaviour and in vitro dissolution. They were compared to a marketed product. Results: The results of the evaluation showed that the tablets had physical characteristics that were within the acceptable limits and were comparable to the marketed product. They include hardness (7.13±1.99 to 13.17±1.59 Kgf), friability (0.40 to 0.80%), and drug content (95.11 to 104.17%). Formulations MTF2 (30% DMG) and MTF6 (20% DMG and 10% NaCMC) showed good sustained release behaviour, as they released 75% of the drug within 7 to 9 h and 100% release in more than 12 h. Conclusion: DMG alone or with NaCMC was successfully used to formulate sustained release metformin matrix tablets that were comparable to the marketed product.

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Section: Drug-excipient Compatibility Studiesmentioning

confidence: 99%

“…Metformin shows characteristic bands at specific regions fig. 3 [24]. Matrix tablets upon contact with water, hydrates, swells, and gels.…”

Section: : %Drug Release From the Sustained Release Metformin Matrixmentioning

confidence: 99%

Design and in Vitro Evaluation of Sustained Release Matrix Tablets of Metformin Produced Using Detarium Microcarpum Gum

2020

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“…[38] High swelling index mucilage may perform well as a binder, disintegrant and matrixing agent. [39] Thus, the mucilage from the leaves of A. manihot, with a significantly high swelling index, may be utilized as a potential disintegrating and binding agent in drug formulation. [25,40]…”

Section: Swelling Indexmentioning

confidence: 99%

Characterization of Mucilages from Abelmoschus Manihot Linn., Amaranthus Spinosus Linn. and Talinum Triangulare (Jacq.) Willd. Leaves for Pharmaceutical Excipient Application

Ang¹,

Raman²

2019

AJBLS

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Introduction: The edible leaves of Abelmoschus manihot Linn., Amaranthus spinosus Linn. and Talinum triangulare (Jacq.) Willd. are exhibiting mucilaginous features and are utilized in making soupy dishes. However, the utilization of the said plant species as sources of mucilages for pharmaceutical excipient application has not yet been reported in literatures. Objectives:The study aimed to extract and partially characterize mucilages from the leaves of A. manihot, A. spinosus and T. triangulare. for potential pharmaceutical excipient application. Materials and Methods: Mucilages were extracted from the leaves of A. manihot, A. spinosus and T. triangulare. Preliminary qualitative tests as well as determination of the physico-chemical properties, i.e. pH, solubility, swelling index, loss on drying, total sugar content and total uronic acid content, were conducted on the extracted mucilages. Identification of functional groups were also carried out through Fourier Transform Infrared (FTIR) spectroscopy. Results and Discussion: Results of the qualitative tests showed detection of carbohydrates, polysaccharides and mucilages among the mucilages extracted from A. manihot, A. spinosus and T. triangulare. The pH values of the extracted mucilage were nearly neutral indicating that they can be less irritating to the gastrointestinal tract when utilize for tablet formulations. Data obtained for the physico-chemical properties showed that mucilages of A. manihot gave statistically different values as compared to the mucilages derived from A. spinosus and T. triangulare. A. manihot mucilage exhibited significantly higher swelling index (357.78%) and total sugar content (273.65 mg glucose/g extract) and significantly lower loss on drying (10.72%) and total uronic acid content (105.20 mg glucuronic acid/g extract) than the other mucilages from A. spinosus and T. triangulare. Furthermore, FTIR spectral analysis showed typical peaks and characteristic bands of mucilage. Conclusion: A. manihot mucilage is promising for utilization as pharmaceutical excipient. However, further analysis is recommended.

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“…Furthermore, the swelling index of Grewia gum provides information about their bioadhesive and sustained release potential and earlier report did not provide a quantitative swelling index for Grewia mollis. 15 Inclusion of additives, application of shear stress during processing and handling as well as environmental temperature variations may influence the viscosity and suitability of Grewia gum as polymeric excipient. The study aimed to prepare Grewia gum using heat or chemical-free method and evaluate its organoleptic, physicochemical, rheological, and microbiological properties.…”

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confidence: 99%

A Cost-Effective Extraction Method for Improved Physicochemical, Rheological and Microbiological Properties of Grewia mollis gum

2020

TJNPR

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Polymeric excipients are an integral part of any formulation as they enhance the loaded drug's stability, bioavailability, and controlled release profile. 1 They include natural (sodium alginate, gelatin, chitosan, Grewia gum), semi-synthetic (cellulose derivatives), synthetic (polyethylene glycols, poloxamers, polylactides, polyamides), and fermentation products (xanthan gum). 2 Gums and mucilages are polysaccharides or complex carbohydrates derived from various plant parts, microorganisms and marine algae. 3 Natural polysaccharide gums such as xanthan, tragacanth, acacia and Grewia gum are preferred over their synthetic counterparts because they are non-toxic, non-irritant, cost-effective, readily available and will not interact with the drug or other formulation and packaging components. 4 Grewia mollis (Fam. Tiliaceae), is an edible plant grown wild or cultivated in the Northern and middle belt region of Nigeria and Grewia gum is typically extracted from its inner stem bark. 5 Structurally, the gum is composed of glucose (67.14%), arabinose (12.71%), galactose (9.61%), rhamnose (6.2%), and xylose (2.72%) as the major monosaccharide. 5,6 It is reported to have an average molecular weight of 5925 kDa and polydispersity of 1.6, which is

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Grewia Gum 1: Some Mechanical and Swelling Properties of Compact and Film

Cited by 3 publications

References 17 publications

Design and in Vitro Evaluation of Sustained Release Matrix Tablets of Metformin Produced Using Detarium Microcarpum Gum

Design and in Vitro Evaluation of Sustained Release Matrix Tablets of Metformin Produced Using Detarium Microcarpum Gum

Characterization of Mucilages from Abelmoschus Manihot Linn., Amaranthus Spinosus Linn. and Talinum Triangulare (Jacq.) Willd. Leaves for Pharmaceutical Excipient Application

A Cost-Effective Extraction Method for Improved Physicochemical, Rheological and Microbiological Properties of Grewia mollis gum

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