Grey matter differences associated with age and sex hormone levels between premenopausal and perimenopausal women: A voxel‐based morphometry study

Lu, Weizhao; Guo, Wei; Hou, Kun; Zhao, Huihui; Shi, Liting; Dong, Kejiang; Qiu, Jianfeng

doi:10.1111/jne.12655

Cited by 18 publications

(26 citation statements)

References 52 publications

(193 reference statements)

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“…The present finding might give potential explanation for depression in women during menopause transition. In addition, a previous voxel-based morphometry study by our group has found that perimenopausal women showed decreased gray matter volume in the right SFG compared with premenopausal women (10). There is a close relationship between structure and function of the human brain (32).…”

Section: Discussionmentioning

confidence: 70%

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Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level

Guo

Qiu

et al. 2021

Front. Endocrinol.

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ObjectiveSerum hormone deficiencies during menopause transition may affect spontaneous brain activity and global cognition. The purpose of this study was to explore the differences in spontaneous brain activity between premenopausal and perimenopausal women, and to investigate the associations between spontaneous brain activity, serum hormone levels and global cognition.MethodsThirty-two premenopausal women (47.75 ± 1.55 years) and twenty-five perimenopausal women (51.60 ± 1.63 years) underwent resting-state functional MRI (fMRI) scan. Clinical information including Mini-Mental State Examination (MMSE), levels of estradiol (E2), free testosterone, progesterone, prolactin, follicle-stimulating hormone and luteinizing hormone were measured. Regional homogeneity (ReHo) was used to evaluate spontaneous brain activity alterations between perimenopausal and premenopausal women. Correlation analysis was used to investigate the associations between brain functional alterations and clinical measures in perimenopausal group.ResultsThe results demonstrated increased ReHo value in the right lingual gyrus (LG) and decreased ReHo value in the right superior frontal gyrus (SFG) in perimenopausal women compared with premenopausal women. In perimenopausal group, ReHo of the right LG showed a negative correlation with level of E2 (r = -0.586, p = 0.002), ReHo of the right SFG showed a positive correlation with level of E2 (r = 0.470, p = 0.018) and MMSE (r = 0.614, p = 0.001).ConclusionsThe results demonstrated that women approaching menopause suffered from altered functions in brain regions related to cognitive function, working memory, the results also revealed a direct association between levels of E2 and brain functions in perimenopausal women.

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Section: Discussionmentioning

confidence: 70%

“…In the recent decade, neuroimaging techniques have been applied to investigate alterations of the brain in women during menopause transition (1,10,(12)(13)(14). Functional magnetic resonance imaging (fMRI), as a popular tool in neuroscience, has been used to study brain functional changes in women during menopause transition (1,12).…”

Section: Introductionmentioning

confidence: 99%

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level

Guo

Qiu

et al. 2021

Front. Endocrinol.

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“…More studies are needed to further investigate the mechanisms. With regard to the relationship between the FSH level and gray matter, previous study showed that the gray matter volume of the right inferior parietal gyrus was decreased in perimenopausal women than premenopausal women ( 41 ). As we all know, the serum FSH level in perimenopausal women was obviously increased than in premenopausal.…”

Section: Discussionmentioning

confidence: 99%

Gray Matter Differences Between Premature Pubertal Girls With and Without the Reactivation of the Hypothalamic—Pituitary-Gonadal Axis

Zhang

Tao

et al. 2020

Front. Psychiatry

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The onset of puberty and related hormones exerts significant effects on brain morphometric and psychosocial development. The biological mechanisms underlying how the reactivation of the hypothalamic-pituitary-gonadal (HPG) axis and puberty-related hormonal maturation sculpts human brain architecture remain elusive. To address this question, 105 premature pubertal girls (age 8-11 years) without menstruation underwent brain structural scanning on a 3T MR system, and the luteinizing hormone releasing hormone (LHRH) stimulation test was used to identify the reactivation of the HPG axis. Among the 105 girls, 63 were positive for HPG axis reactivation (HPG+), while the others showed negative (HPG-). Cortical thickness was calculated and compared between the two groups after adjusting for age. The brain regions showing inter-group differences were then extracted and correlated with the peak value of serum hormone after the LHRH stimulation test in entire sample. Compared to HPG-girls, HPG+ girls showed reduced cortical thickness mainly in the the right precuneus, right inferior temporal gyrus, and right superior frontal gyrus, while increased cortical thickness primarily in the left superior parietal lobe and right inferior parietal lobe. Linear-regression analysis revealed negative correlations between the cortical thickness of the right inferior parietal lobe with the peak value of FSH and the right precuneus with LH and E. These findings provide evidence to support the notion that the reactivation of HPG axis and changes of hormones during the early phase of hormonal maturation exert influences on the development of gray matter.

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“…The frontal cortex and posterior cingulate cortex showed consistent biomarker abnormalities in peri- and postmenopausal women [ 6 ]. Lu et al found that the gray matter volume in multiple brain regions of perimenopausal women decreased [ 7 ]. However, previous studies of perimenopausal women mainly focused on the changes in brain structure and morphology, not yet revealed the overall changes in the spontaneous activity of whole brain,which did not point out abnormal area of the brain accurately.…”

Section: Introductionmentioning

confidence: 99%

Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women

et al. 2021

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Background There is a noticeable lack of systematic researches on evaluating the correlation between serum estrogen levels and changes in brain functional areas of perimenopausal women.The aim of this study is to investigate the regional spontaneous brain activity changes in perimenopausal women. Methods Based on the resting-state functional magnetic resonance imaging datasets acquired from 25 perimenopausal women and 20 healthy women of reproductive age, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the self-rating anxiety scale (SAS), the self-rating depression scale (SDS) were investigated with Pearson correlation analysis. We also investigated the correlation between abnormal ReHo values and serum estrogen level. Results In the perimenopausal group, we found increased ReHo in the right posterior cerebellum (region 2), left middle frontal gyrus and left middle cingulate gyrus ($$P<0.05$$ P < 0.05 ). Additionally, the ReHo values in left middle frontal gyrus and leftt middle cingulate gyrus showed positively significant correlation with the SAS, SDS scores. On the contrary, there was no significant correlation between the ReHo value in right posterior cerebellum and SDS, SAS scores. In the perimenopausal group, the ReHo values in the left middle frontal gyrus and left middle cingulate gyrus were negatively correlated with the serum estrogen level ($$P<0.05$$ P < 0.05 ). Conclusion The results of this preliminary study have suggested that abnormal spontaneous activities of multiple brain regions during resting state was already altered in perimenopausal women. Alterative activities might be related to emotional regulation deficits and cognitive impairment, and might potentially represent the neural mechanism underlying perimenopausal period.

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Grey matter differences associated with age and sex hormone levels between premenopausal and perimenopausal women: A voxel‐based morphometry study

Cited by 18 publications

References 52 publications

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level

Gray Matter Differences Between Premature Pubertal Girls With and Without the Reactivation of the Hypothalamic—Pituitary-Gonadal Axis

Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women

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