Grey matter pathology in clinically early multiple sclerosis: Evidence from magnetic resonance imaging

Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging

“…[6][7][8][9]20,21 In our study, cortical lesion measures reflected nearly entirely cortical-subcortical types and showed moderate correlations with white matter lesion volume, suggesting that the underlying pathogenic processes might be related. The relationship between inflammatory demyelinating lesions in white matter and gray matter has previously demonstrated conflicting results: Some studies found correlation, 30,32,35,36 whereas others did not.…”

“…In vivo assess-ment of cortical lesions is of great significance because the pathologic processes that have taken place in the gray matter and their relationship to white matter pathology and gray matter atrophy and clinical outcomes will improve our understanding of MS pathogenesis. 20,21 In the present study, we used a high-resolution 3T brain MR imaging protocol that combined a multiplanar display of 3D FLAIR and T1-weighted 3D IR-SPGR sequences. This approach took advantage of the high contrast sensitivity of FLAIR for imaging cortical lesions combined with IR-SPGR to delineate the boundary between the cortex and white matter.…”

Exploring the origins of grey matter damage in multiple sclerosis

“…As would later be apparent, this was a gross underestimation of actual grey matter damage. It was another four decades before advances in imaging techniques 9,10 , supported by immunohistochemical observations and animal models, renewed the interest in grey matter pathology in multiple sclerosis and began to reveal its high prevalence and to uncover the detailed cellular pathology of grey matter demyelination [11][12][13] .…”

Pseudotumoral Form of Multiple Sclerosis With Symptomatic Convulsive Seizures (A Clinical Case)

“…При РС в нейродегенеративный процесс включается не только белое вещество мозга, в котором преобладают процессы демиелинизации, но и серое вещество мозга, где выражено нейрональ-ное поражение [11]. Одна из последних классифика-ций демиелинизирующих очагов в сером веществе характеризует 3 типа корковых очагов: 1-й тип -оча-ги в сером веществе, характеристики которых подоб-ны изменениям в белом веществе; 2-й тип -неболь-шие внутрикорковые периваскулярные зоны демиелинизации; 3-й тип -очаги на субпиальной поверхности коры, обычно достигающие 4-5-го слоев коры [13].…”