Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis

Liu, Han; Hao, Zeqi; Qiu, Shasha; Wang, Qianqian; Zhan, Linlin; Huang, Lina; Shao, Youbin; Wang, Qing; Su, Chang; Cao, Yikang; Sun, Jiawei; Wang, Chunjie; Lv, Yating; Li, Mengting; Shen, Wenbin; Li, Huayun; Jia, Xize

doi:10.1007/s11682-023-00842-x

Cited by 4 publications

(2 citation statements)

References 151 publications

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“…However, since our putamen finding was independent of the diagnoses of MDD, ADHD, anxiety disorder, and eating disorder (see online Supplementary Table S5), we can speculate that putamen alterations might be a vulnerability marker specific to BD. This notion is also supported by the evidence that diagnoses of MDD, ADHD, and anxiety disorder were more frequently associated with decreased rather than increased putamen volumes (Liu et al, 2023;Lu et al, 2016;Lu et al, 2019a;Luo et al, 2019;Pan et al, 2023;Sacchet, Camacho, Livermore, Thomas, & Gotlib, 2017;Talati et al, 2022). Since our putamen finding was also independent of familial risk of BD, MDD, schizophrenia, and schizoaffective disorder (see online Supplementary Table S5), this potential vulnerability marker likely occurred due to a combination of both genetic and non-genetic risk factors for BD.…”

Section: Discussionsupporting

confidence: 79%

“…Alterations of the putamen might lead to an increased liability for cognitive deficits, emotion dysregulation, and impulsive behavior, some of the typical features of BD (Luo et al, 2019;Strakowski et al, 2005;Whitton et al, 2015). Altered putamen volume has been consistently shown in BD (Lu et al, 2019b;Yu et al, 2019), but also in other psychiatric disorders, like MDD, ADHD, anxiety disorder, schizophrenia, post-traumatic stress disorder, or obsessive-compulsive disorder (Gong et al, 2019;Liu et al, 2023;Luo et al, 2019). Gong et al (2019) found increased putamen volume across patients with MDD, schizophrenia, obsessive-compulsive disorder, and post-traumatic stress disorder, as well as in unaffected relatives with a positive family history of these disorders, relative to HCs.…”

Section: Discussionmentioning

confidence: 99%

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Larger putamen in individuals at risk and with manifest bipolar disorder

Thomas-Odenthal,

Stein,

Vogelbacher

et al. 2024

Psychol. Med.

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Background: Individuals at risk for bipolar disorder (BD) have a wide range of genetic and non-genetic risk factors, like a positive family history of BD or (sub)threshold affective symptoms. Yet, it is unclear whether these individuals at risk and those diagnosed with BD share similar gray matter brain alterations. Methods: In 410 male and female participants aged 17–35 years, we compared gray matter volume (3T MRI) between individuals at risk for BD (as assessed using the EPIbipolar scale; n = 208), patients with a DSM-IV-TR diagnosis of BD (n = 87), and healthy controls (n = 115) using voxel-based morphometry in SPM12/CAT12. We applied conjunction analyses to identify similarities in gray matter volume alterations in individuals at risk and BD patients, relative to healthy controls. We also performed exploratory whole-brain analyses to identify differences in gray matter volume among groups. ComBat was used to harmonize imaging data from seven sites. Results: Both individuals at risk and BD patients showed larger volumes in the right putamen than healthy controls. Furthermore, individuals at risk had smaller volumes in the right inferior occipital gyrus, and BD patients had larger volumes in the left precuneus, compared to healthy controls. These findings were independent of course of illness (number of lifetime manic and depressive episodes, number of hospitalizations), comorbid diagnoses (major depressive disorder, attention-deficit hyperactivity disorder, anxiety disorder, eating disorder), familial risk, current disease severity (global functioning, remission status), and current medication intake. Conclusions: Our findings indicate that alterations in the right putamen might constitute a vulnerability marker for BD.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Larger putamen in individuals at risk and with manifest bipolar disorder

Thomas-Odenthal,

Stein,

Vogelbacher

et al. 2024

Psychol. Med.

View full text Add to dashboard Cite

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Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders

Fortea,

Ortuño,

De Prisco

et al. 2024

Biological Psychiatry

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Pain resilience dimensions and regional gray matter volume as risk factors for poor outcomes of chronic pain: a prospective cohort study

You,

Wen,

Jackson

2024

Psychol. Med.

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Background Pain resilience and regional gray matter volume (rGMV) are established correlates of adaptation to chronic pain within cross-sectional studies. Extending such work, this prospective cohort study tested the status of baseline pain resilience dimension scores and rGMV as risk factors for subsequent exacerbations in chronic pain disability and intensity. Methods 142 adults with chronic musculoskeletal pain completed an initial assessment comprising a structural magnetic resonance imaging scan and self-report measures of cognitive/affective positivity and behavioral perseverance pain resilience dimensions, disability, pain intensity, and demographics. Disability and pain intensity were outcomes re-assessed at a 6-month follow-up. The impact of pain resilience dimension scores and identified rGMV sites on follow-up outcomes was examined after controlling for other baseline correlates of outcomes. Mediating effects of identified rGMV sites on pain resilience dimension-follow-up outcome relations were also evaluated. Results Aside from the significant multivariate effect of lower behavioral perseverance and cognitive/affective positivity scores, augmented left precuneus, temporal pole, superior temporal gyrus (STG), and precentral gyrus rGMV combined to predict higher follow-up disability levels, independent of covariates. Higher left fusiform gyrus rGMV levels predicted follow-up exacerbations in pain intensity, but pain resilience dimension scores did not. Finally, left precuneus and left temporal pole STG rGMV partially mediated cognitive/affective positivity-follow-up disability relations. Conclusions Findings underscore deficits in pain resilience and increased rGMV as potential risk factors for poorer subsequent outcomes of chronic musculoskeletal pain and provide foundations for further prospective extensions as well as targeted intervention research.

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Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis

Cited by 4 publications

References 151 publications

Larger putamen in individuals at risk and with manifest bipolar disorder

Larger putamen in individuals at risk and with manifest bipolar disorder

Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders

Pain resilience dimensions and regional gray matter volume as risk factors for poor outcomes of chronic pain: a prospective cohort study

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