Grignard dehydration reactions. An undergraduate organic experiment.

The Question-Driven Laboratory Exercise: A New Pedagogy Applied to a Green Modification of Grignard Reagent Formation and Reaction

“…One of the most featured reactions in second-year-level organic chemistry is the Grignard reaction because the Grignard reagent is so versatile, enabling the synthesis of a wide variety of functional groups. The Grignard reaction has been featured in experiments in this Journal 15 times − and an experimental Grignard procedure exists in almost every published laboratory manual. Despite the academic attention that Grignard chemistry has attracted, it is not a reaction that is used often in an industrial setting.…”