Grinding-induced rapid, convenient and solvent free approach for the one pot synthesis of α-aminophosphonates using aluminium pillared interlayered clay catalyst

Kabachnik–Fields Reaction by Mechanochemistry: New Horizons from Old Methods

“…with ZrCl 4 ), solvent-free [ e.g . with Cp 2 Zr­(OSO 2 C 4 F 9 ) 2 ·2H 2 O, ZrOCl 2 · 8H 2 O, or ZrO­(ClO 4 ) 2 · 6H 2 O] or by grinding over Zr-supported pillared clay …”

“…Novel reaction conditions based on activation by alternative energy inputs in "batch" (microwaves, 21,33 ultrasounds 34 ) or under continuous flow, [35][36] with sustainable solvents 37 or solvent-free 24 (including manual grinding in a mortar), 38 catalyzed or not, were explored to improve the selectivity, the reaction efficiency, and the environmental footprint of KF-3CR compared to the conventional methods in solution. 17,24,26 To our surprise, no reports deal with the use of mechanochemical procedures for the preparation of α-aminophosphonic acid derivatives and more generally for the formation of C(sp 3 )-phosphorus bonds, while only one account describes the metal-catalyzed C(sp 2 )phosphorus bond formation in a ball-mill.…”

“…Novel reaction conditions based on activation by alternative energy inputs in “batches” (microwaves, , ultrasounds) or under continuous flow, , with sustainable solvents or solvent-free (including manual grinding in a mortar), catalyzed or not, were explored to improve the selectivity, reaction efficiency, and environmental footprint of KF-3CR compared to the conventional methods in solution. ,, …”

“…with Cp 2 Zr(OSO 59  or by grinding over Zr-supported pillared clay. 38 Based on all these findings, zirconium oxide jars (and balls) may play a double role, acting at Commercially available milling media based on zirconium oxide have never been explored as heterogeneous and 'recyclable' 'catalyst' in any metal-mediated mechanochemical transformation described in the literature, 60 outperforms in comparison with stainless steel jars and complement the previous findings making use of manufactured on purpose copper-, [49][50] nickel-51 and palladium-52 milling media to catalyze 'click' 3+2, 2+2+2+2 cycloaddition, and Suzuki-Miyaura reactions respectively.…”

Insight into the Reaction Mechanism of α‐Amino Phosphonate Synthesis Using Succinic Acid as a Catalyst: Computational Kinetic Approach

“…Therapeutic activities, such as those of antithrombotic agents, HIV protease, antibiotics, antihypertensive agents, anticancer agents, potential antioxidants, biotryticides, haptens of catalytic antibodies, enzyme inhibitors, catalytic antibodies, anti‐inflammatory agents, carriers of hydrophilic organic molecules across phospholipid membrane, etc., can be attributed to these compounds. They are also used as herbicides, fungicides, hypothetical radio‐protecting agents, plant virucides ,and insecticides, which have prompted researchers to learn the techniques for the synthesis of α‐amino phosphonates and their derivatives. Among the numerous approaches, the most preferred method is the nucleophilic addition of phosphites to imines, which is commonly catalyzed by an appropriate catalyst .…”