Gross and Histomorphologic Study of the Umbilical Cord in Pre-gestational Diabetes Mellitus and Gestational Diabetes Mellitus

Alam, Rafiqul; Momen, Abdul; Sultana, Anjuman Ara; Hassan, SM Nurul

doi:10.3329/bja.v12i1.22615

Cited by 8 publications

(10 citation statements)

References 6 publications

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“…In the present study the mean diameter in all the groups are (1.16 ± 0.36), (1.04 ± 0.17) and (1.06 ± 0.24) in control, PIH and PIH+GDM group respectively. The mean diameter in case of control group has similarities with the study of Akhtari Afrose 9 , Laila perveen Banu 10 , Rafiqul Alam 11 and Mallika Karmaker 12 . In case of hypertensive and/or diabetes mellitus mean diameter of umbilical cord differ at nonsignificant level from the control group.…”

Section: Discussionsupporting

confidence: 69%

“…Regarding the number of the umbilical vessels, 2 arteries and 1 vein were found in all the samples of the present study which have the similarities with the study of above mentioned investigators. But it was reported also that there may be absence of one umbilical artery or presence of more than two umbilical arteries in some studies(Hyrti cited by Vientick et al cited by Rafique 11 . Nadkarni cited by Rafique 11 , found in his study that four cords containing three arteries and one containing one artery.…”

Section: Discussionmentioning

confidence: 99%

“…But it was reported also that there may be absence of one umbilical artery or presence of more than two umbilical arteries in some studies(Hyrti cited by Vientick et al cited by Rafique 11 . Nadkarni cited by Rafique 11 , found in his study that four cords containing three arteries and one containing one artery.…”

Section: Discussionmentioning

confidence: 99%

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Study of Umbilical Cord in Pregnancy Induced Hypertension with and without Diabetes Mellitus

2015

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Context : Two organs that can provide a good insight into pregnancy induced hypertension with and without diabetes mellitus are the placenta and the umbilical cord along with their vessels. In the present study the umbilical cord is taken from the placenta of hypertensive and diabetic mothers to measure its diameter, to observe contained vessels and its mode of attachment to the placenta. Materials and Methods: An observational and analytical type of study was conducted in the department of Anatomy, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka between November 2003 to May 2004 on umbilical cords. To study the umbilical cord, placentas were collected from fifty eight Bangladeshi women who gave birth to a single live baby through Caesarian section after 35 to 40 weeks of gestasion. Twenty of the mothers were non hypertensive, non diabetic control, twenty had pregnancy induced hypertension(PIH) and eighteen had pregnancy induced hypertension and gestesional diabetes mellitus(PIH+GDM). Results: No significant difference was found between any groups for diameter of the umbilical cord. All the umbilical cords had same number of vessels. There was variation among the mode of insertion of umbilical cord. Conclusion: Diameter of umbilical cords did not show significant difference in either of the two diseased groups with the control group in the Post Hoc option of analysis of variance (ANOVA) at 5% level. DOI: http://dx.doi.org/10.3329/bja.v12i1.22609 Bangladesh Journal of Anatomy, January 2014, Vol. 12 No. 1 pp 03-06

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Study of Umbilical Cord in Pregnancy Induced Hypertension with and without Diabetes Mellitus

2015

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“…These finding agreed with Salem et al, [30] who found that areas of hemorrhage and red blood cells were found free in the wall of the peripheral arteries of diabetic patients. Alam et al, [31] also found rupture and erosions of endothelial lining of umbilical arteries resulting in increased permeability of the vessels in diabetes.…”

Section: Discussionmentioning

confidence: 94%

“…Thirty pregnant women with full term (37-40 wks.) gestation with age ranging from (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) years old having single pregnancy coming for delivery (normal or caesarian sections) at Obstetrics and Gynecology Department, Al Zhraa University Hospital were used during period from October 2017 till March 2018.…”

Section: Methodsmentioning

confidence: 99%

Histological Study of Human Umbilical Cord in Diabetic Pregnant Females

Salem

El-Gawwad

Mahmoud³

et al. 2020

Egyptian Journal of Histology

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Background:The umbilical cord (UC) is the lifeline between the fetus and placenta. It allows gas and nutrient exchange. Diabetes mellitus is the most common metabolic disorder that occurs during pregnancy, it has complications on both mother and fetus. The changes in the structure of UC with diabetes may have effect on the viability of the fetus. Aim of the Work: Is to study the effect of gestational diabetes on the histological structure of UC. Patients and Methods: The umbilical cord biopsies were collected immediately after delivery from 30 full term pregnant women, 15 normal pregnant females (Control group), and 15 pregnant women had gestational diabetes (Diabetic group). Informed written consent was taken from all pregnant women sharing in this study. These biopsies were processed for light and electron microscopic studies. Also morphometric and statistical analysis for the data were done. Results: Light microscopic study of diabetic UC samples showed degeneration of Wharton's jelly fibers with formation of honey comb like empty spaces. Erosion of endothelial cells lined the umbilical vessels; with separation of their smooth muscle fibers were observed. There were degeneration of collagen fibers and decrease amount of elastic fibers in the wall of umbilical vessels. Morphometric studies showed significant decrease in the intima and media thickness in diabetic UC arteries compared to UC control arteries. The UC vein of diabetic samples showed significant dilatation of the lumen and thinner wall compared to that of control group. Conclusion:The present study proved that gestational diabetes has many injurious effects on histological structure of UC.

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The effect of vascular complications of diabetes mellitus on human umbilical cord tissue and the number of Wharton Jelly’s mesenchymal stem cells

et al. 2020

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Gross and Histomorphologic Study of the Umbilical Cord in Pre-gestational Diabetes Mellitus and Gestational Diabetes Mellitus

Cited by 8 publications

References 6 publications

Study of Umbilical Cord in Pregnancy Induced Hypertension with and without Diabetes Mellitus

Study of Umbilical Cord in Pregnancy Induced Hypertension with and without Diabetes Mellitus

Histological Study of Human Umbilical Cord in Diabetic Pregnant Females

The effect of vascular complications of diabetes mellitus on human umbilical cord tissue and the number of Wharton Jelly’s mesenchymal stem cells

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