Group 1 innate lymphoid cells are involved in the progression of experimental anti-glomerular basement membrane glomerulonephritis and are regulated by peroxisome proliferator-activated receptor α

Okabayashi, Yusuke; Nagasaka, Shinya; Kanzaki, Go; Tsuboi, Nobuyuki; Yokoo, Takashi; Shimizu, Akira

doi:10.1016/j.kint.2019.04.039

Cited by 10 publications

(8 citation statements)

References 68 publications

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“…Bernink et al (2013) revealed that the frequency of circulating ILC1s was elevated in intestinal injury and ILC1-derived IFN-γ exaggerated inflammation. Furthermore, Okabayashi et al (2019) reported that treatment with ILC1-targeted receptor agonist attenuated renal injury by downregulating T-bet mRNAs expression and reducing IFN-γ production. Through IFN-γ secretion, ILC1s can aid Th1 cell priming and modulate Th1 immune response directly or indirectly (Sonnenberg and Hepworth, 2019).…”

Section: Discussionmentioning

confidence: 99%

The Tipped Balance of ILC1/ILC2 in Peripheral Blood of Oral Lichen Planus Is Related to Inflammatory Cytokines

Wang

Zhang

Wang

et al. 2022

Front. Cell Dev. Biol.

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Oral lichen planus (OLP) is an immune-inflammatory disease mediated by T cells. Innate lymphoid cells (ILCs) constitute a novel family of immune cells that initially originate from common innate lymphoid progenitors. Termed “T cells counterparts,” ILCs play a prominent role in inflammatory-immune diseases. However, the characterization of ILCs and their related induced factors were unclear in OLP. In the present study, the phenotypic characteristics of ILCs and their correlation with inflammatory cytokines were explored in the peripheral blood of OLP patients and healthy controls. We found that the proportion of total ILCs was expanded in OLP and was positively correlated with disease severity. The highly skewed distribution of ILC subpopulations was notable in OLP. Specifically, the frequency of ILC1s was significantly increased, while that of ILC2s was significantly reduced in total ILCs of OLP, resulting in the markedly elevated ILC1/ILC2 ratio in OLP. Correspondingly, ILCs in OLP displayed high expression of T-bet but low expression of GATA3. In addition, the IFN-γ expression level was elevated in ILC1s, whereas the IL-4 expression level was decreased in ILC2s. Moreover, ILC-associated activators IL-12, IL-18, and IL-1β were upregulated in OLP plasma, with IL-12 and IL-1β both positively correlated with the ILC1/ILC2 ratio. Further in vitro stimulation tests indicated that OLP plasma remarkedly increased the ILC1/ILC2 ratio, especially that IL-12 and IL-1β tipped the balance between ILC1s and ILC2s toward ILC1s in total ILCs. Overall, elevated levels of IL-12 and IL-1β might act as environmental cues in tipping the balance of ILC1/ILC2 in the peripheral blood of OLP, contributing to the immune dysregulation in OLP.

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Section: Discussionmentioning

confidence: 99%

The Tipped Balance of ILC1/ILC2 in Peripheral Blood of Oral Lichen Planus Is Related to Inflammatory Cytokines

Wang

Zhang

Wang

et al. 2022

Front. Cell Dev. Biol.

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“…Anti-GBM glomerulonephritis was induced in Wistar-Kyoto rats (Charles River Japan, Kanagawa, Japan) by a single intravenous injection of rabbit anti-rat GBM antibodies (50 µg IgG/100 g body weight) as described previously 3,4,8,22 . To evaluate the effects of DSF (NOCBIN, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan), the rats were orally administered DSF (50 or 100 mg/kg/day) or vehicle (0.5% w/v carboxymethyl cellulose) once daily, initiated on the day before injecting the anti-GBM antibody.…”

Section: Induction Of Anti-gbm Glomerulonephritis In Ratsmentioning

confidence: 99%

Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis

Toda

Sawada

Takeuchi

et al. 2022

Kidney International

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“…While in the MRL-lpr model the other helper ILC subsets were unaltered (20), a recent study suggested that a previously unknown ILC1 subtype expressing CD8 might infiltrate glomeruli in rat and potentially also in human anti-GBM nephritis (49). However, if this CD8 + cell subset indeed FIGURE 2 | Protective role of ILC2s in chronic kidney diseases.…”

Section: Ilcs In Glomerulonephritismentioning

confidence: 97%

Innate Lymphoid Cells in Renal Inflammation

2020

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Since their identification as a separate family of leukocytes, Innate lymphoid cells (ILCs) have been shown to play crucial roles in immune-mediated diseases and repair mechanisms that restore tissue integrity after injury. ILCs mainly populate non-lymphoid tissues where they form intricate circuits with parenchymal cells to regulate tissue immunity and organ homeostasis. However, the specific phenotype and function of ILC populations that reside in specific anatomical locations, such as the kidney, still remains poorly understood. In this review, we discuss tissue-specific properties of kidney-residing ILCs and summarize recent advances in the understanding of ILC biology in kidney diseases that might pave the way for development of novel treatment strategies in humans.

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Group 1 innate lymphoid cells are involved in the progression of experimental anti-glomerular basement membrane glomerulonephritis and are regulated by peroxisome proliferator-activated receptor α

Cited by 10 publications

References 68 publications

The Tipped Balance of ILC1/ILC2 in Peripheral Blood of Oral Lichen Planus Is Related to Inflammatory Cytokines

The Tipped Balance of ILC1/ILC2 in Peripheral Blood of Oral Lichen Planus Is Related to Inflammatory Cytokines

Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis

Innate Lymphoid Cells in Renal Inflammation

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