Group 2 Innate Lymphoid Cells and IL-9 Receptor Are Increased in Active Eosinophilic Esophagitis

Doshi, Ami; Baum, Rachel; Holanda, Paulo; Cavagnero, Kellen; Bell, Braxton; Dohil, Lucas; Newbury, Robert; Aquino, Melissa; Kurten, Richard C.; Doherty, Taylor; Aceves, Seema S.

doi:10.1016/j.jaci.2015.12.1162

Cited by 2 publications

(2 citation statements)

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“…Finally, the collaborators who identified ILC2 in EoE expanded their findings in a preliminary report. 91 They identified a key cytokine, IL-9, in regulating ILC2 biology and found that ILC2 from patients with active EoE upregulated IL-9R expression. 91 We compiled information from recently published studies to construct a tabular review of inflammatory esophagitis (Table 1).…”

Section: Eosinophilic Esophagitismentioning

confidence: 99%

“…91 They identified a key cytokine, IL-9, in regulating ILC2 biology and found that ILC2 from patients with active EoE upregulated IL-9R expression. 91 We compiled information from recently published studies to construct a tabular review of inflammatory esophagitis (Table 1). The relative presence of the constitutively present or increased inflammatory cell population indicates the strength of the literature evidence for the cells (present in esophageal tissue) that might contribute to the pathology of different esophageal inflammatory subtypes.…”

Section: Eosinophilic Esophagitismentioning

confidence: 99%

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Role of innate lymphoid cells in allergic diseases

Pasha

Patel

Hopp

et al. 2019

allergy asthma proc

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Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

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Section: Eosinophilic Esophagitismentioning

confidence: 99%

Section: Eosinophilic Esophagitismentioning

confidence: 99%