Group A streptococcal brain abscess in children: two case reports and a review of the literature

Hazan, Guy; Kristal, Eyal; Gideon, Michael; Tzudikov, Vadim; Cavari, Yuval; Fruchtman, Yariv; Ben‐Shimol, Shalom; Leibovitz, Eugene; Lazar, Isaac; Melamed, Rimma

doi:10.1080/23744235.2017.1374551

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…A Japanese researcher reported a case of GAS as a rare cause for idiopathic pyomyositis (Minami et al, 2017). Researchers have described the relationship of intracranial abscesses in children and GAS (Hazan et al, 2018; Link-Gelles et al, 2020). Invasive disease has been associated with an increase in morbidity and mortality, with an overall 7-day case fatality rate of 19% (Lamagni et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Severe Lactational Mastitis With Complicated Wound Infection Caused by Streptococcus pyogenes

et al. 2020

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Introduction Puerperal mastitis, a complication occurring during the breastfeeding period, is often caused by Staphylococcus aureus. Here we report on severe streptococcal mastitis in a lactating breast, with subsequent invasive disease and wound healing problems. Main issue The 41-year-old woman (G2, P2) presented at 2 weeks postpartum to our hospital with painful swelling and reddening of the left breast, in addition to fever and malaise, and complained about a nipple fissure on the left breast. Previously, her 4-year-old son was treated for an acute otitis media and her husband experienced flu-like symptoms. Management Due to the severity of the symptoms, Clindamycin antibiotic treatment was initiated intravenously. Streptococcus pyogenes was isolated in the milk. This strain is commonly known to cause infections of the upper respiratory tract, skin, and soft tissue, but rarely mastitis. Furthermore, the participant developed invasive disease with abscess formation and skin erosion with a milk fistula. Special dressing was applied to promote wound healing. The participant continued breastfeeding well into the child’s 2nd year of life. Conclusion This rare form of complicated mastitis with invasive disease caused by Streptococcus pyogenes called for an interdisciplinary approach. We want to draw attention to other pathogens causing mastitis and to alert health care workers to promote hygiene in lactating women to prevent transmission.

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Section: Discussionmentioning

confidence: 99%

Severe Lactational Mastitis With Complicated Wound Infection Caused by Streptococcus pyogenes

et al. 2020

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Group A Streptococcal meningitis in children: a short case series and systematic review

Dou,

Li,

et al. 2024

Eur J Clin Microbiol Infect Dis

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Background Group A streptococcal(GAS) meningitis is a severe disease with a high case fatality rate. In the era of increasing GAS meningitis, our understanding about this disease is limited. Purpose To gain a better understanding about GAS meningitis. Methods Five new cases with GAS meningitis were reported. GAS meningitis related literatures were searched for systematic review in PUBMED and EMBASE. Case reports and case series on paediatric cases were included. Information on demographics, risk factors, symptoms, treatments, outcomes, and emm types of GAS was summarized. Results Totally 263 cases were included. Among 100 individuals, 9.9% (8/81) had prior varicella, 11.1% (9/81) had anatomical factors, and 53.2% (42/79) had extracranial infections. Soft tissue infections were common among infants (10/29, 34.5%), while ear/sinus infections were more prevalent in children ≥ 3 years (21/42, 50.0%). The overall case fatality rate (CFR) was 16.2% (12/74). High risk of death was found in patients with shock or systemic complications, young children(< 3 years) and cases related to hematogenic spread. The predominate cause of death was shock(6/8). Among the 163 patients included in case series studies, ear/sinus infections ranged from 21.4 to 62.5%, while STSS/shock ranged from 12.5 to 35.7%, and the CFR ranged from 5.9 to 42.9%. Conclusions A history of varicella, soft tissue infections, parameningeal infections and CSF leaks are important clinical clues to GAS in children with meningitis. Young children and hematogenic spread related cases need to be closely monitored for shock due to the high risk of death.

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Abszess (zerebral)

Moore¹,

Jhaveri²,

Salzman³

et al. 2023

Diagnostic Imaging: Pädiatrische Neuroradiologie

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Group A streptococcal brain abscess in children: two case reports and a review of the literature

Cited by 4 publications

References 18 publications

Severe Lactational Mastitis With Complicated Wound Infection Caused by Streptococcus pyogenes

Severe Lactational Mastitis With Complicated Wound Infection Caused by Streptococcus pyogenes

Group A Streptococcal meningitis in children: a short case series and systematic review

Abszess (zerebral)

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