Group B streptococcal colonization and antibody status in lower socioeconomic parturient women

Beachler, Craig W.; Baker, Carol J.; Kasper, Dennis L.; Fleming, Darrel; Webb, Bette J.; Yow, Martha D.

doi:10.1016/0002-9378(79)90470-8

Cited by 32 publications

(11 citation statements)

References 13 publications

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“…Previous studies on the association of GBS colonization and serum IgG antibody have mainly been cross-sectional studies and have generally reported higher serotype-specific CPS antibody in colonized compared to noncolonized pregnant women for the homotypic serotype [15][16][17][18][19][20][21][22]. These studies were, however, not designed to address whether CPS antibody reduces the risk of GBS colonization during pregnancy, as shown by us.…”

Section: Discussionmentioning

confidence: 69%

“…A few predominantly cross-sectional studies have reported higher serotype-specific capsular polysaccharide (CPS) antibody in colonized compared to noncolonized women [15][16][17][18][19][20][21][22]. We are, however, unaware of any longitudinal cohort study which evaluated the association between serotype-specific CPS antibody and subsequent risk of GBS rectovaginal acquisition during the latter half of pregnancy.…”

Section: Introductionmentioning

confidence: 97%

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Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women

Kwatra

Adrian

Shiri

et al. 2015

Clinical Microbiology and Infection

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Group B Streptococcus (GBS) rectovaginal colonization in pregnant women is associated with invasive GBS disease in newborns, preterm delivery and stillbirths. We studied the association of GBS serotype-specific capsular polysaccharide (CPS) antibody on new acquisition and clearance of rectovaginal GBS colonization in pregnant women from 20 weeks until 37 to 40 weeks' gestation. Serum serotype-specific CPS IgG antibody concentration was measured by multiplex enzyme-linked immunosorbent assay and opsonophagocytic activity (OPA) titres. Rectovaginal swabs were evaluated for GBS colonization, using standard culture methods and serotyping by latex agglutination, at five to six weekly intervals. Higher serotype III CPS antibody concentration was associated with lower risk of rectovaginal acquisition of serotype III during pregnancy (p 0.009). Furthermore, serotype-specific OPA titres to Ia and III were higher in women who remained free of GBS colonization throughout the study compared to those who acquired the homotypic serotype (p <0.001 for both serotypes). Serum CPS IgG values of ≥1μg/mL for serotype V and ≥3μg/mL for serotypes Ia and III were significantly associated with protection against rectovaginal acquisition of the homotypic serotype. A GBS vaccine that induces sufficient capsular antibody in pregnant women, including high OPA titres, could protect against rectovaginal colonization during the latter half of pregnancy.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 97%

Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women

Kwatra

Adrian

Shiri

et al. 2015

Clinical Microbiology and Infection

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“…In various studies [27,29,35,36] no significant differences in colonisation rates were noted on the basis of age or parity, but increasing age [5] and parity [5,14] have also sometimes been associated with lower rates of carriage. However, Regan et al [2] described GBS carriage as being more common among older women and women of lower parity.…”

Section: Commentmentioning

confidence: 99%

Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Berg

Sprij

Oostvogel³

et al. 2006

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: This study was performed to determine the prevalence of GBS and to identify GBS colonisation risk factors in a multicultural population of pregnant women in The Netherlands. We calculated predictive values of cultures in pregnancy for intrapartum GBS carriage. Study design: From a total of 1702 women visiting several antenatal outpatient departments, rectovaginal swabs were collected at 35-37 weeks' gestation. In 761 women swabs were repeated at time of delivery. Carriage of GBS late in third trimester and at time of delivery was analysed in relation to age, parity, ethnicity and socio-economic status. Results: Twenty-one percent was GBS carrier late in pregnancy. Compared to Europeans, African women were at a higher risk (29%, RR 1.4, CI 1.1-1.7) and Asian women were at lower risk (13%, RR 0.6, CI 0.4-0.8) for GBS carriage. No differences in colonisation were found between women with respect to age, parity or socio-economic background. Positive predictive value of GBS carriage at 35-37 weeks' gestation for carriage at time of parturition was 79% and negative predictive value was 93%. Conclusions: It was not possible to identify a group of pregnant women at high risk for GBS colonisation. Predictive values of antenatal genital group B streptococci cultures at 35-37 weeks' gestation for intrapartum GBS carriage are lower than previously reported. # 2005 Published by Elsevier Ireland Ltd.

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“…However in another study involving Turkish pregnant women parity was observed to be unrelated to GBS carriage. Whereas according to Beachler and Baker (1979) no differences were found with colonized and non-colonized women with respect to age, race, marital status or parity 21 . Regan et al described GBS carriage as more common among older women and women of lower parity 11 .…”

Section: Figure-3 : Relationship Between Gbs Colonization and Paritymentioning

confidence: 71%

Prevalence and Antibiogram of Vaginal Carriage of Group B Streptococci in Third Trimester of Pregnancy and Its Feto-Maternal Outcome

Netto¹

2018

jmscr

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Group B streptococcal colonization and antibody status in lower socioeconomic parturient women

Cited by 32 publications

References 13 publications

Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women

Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women

Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Prevalence and Antibiogram of Vaginal Carriage of Group B Streptococci in Third Trimester of Pregnancy and Its Feto-Maternal Outcome

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