Group I pepsinogen for early detection of gastric cancer recurrence after total gastrectomy

Abstract

Group I pepsinogen (PG-I) staining was performed in the gastric carcinoma tissues of 75 patients by the peroxidase-antiperoxidase (PAP) method, 44 cases (59%) of which were positive for PG-I, suggesting that they were PG-I-producing gastric carcinomas. Type IV gastric carcinoma by the Borrmann classification and/or poorly-differentiated adenocarcinoma were positive for PG-I in high incidence. Serum and urinary levels of PG-I were determined by the Pepsinogen I Radioimmunoassay Kit in patients with gastric carcinoma who underwent total gastrectomy. The levels of PG-I declined remarkably or disappeared at 1 week after curative surgery. Changes of serum PG-I levels after total gastrectomy were observed in 9 patients with PG-I-producing gastric carcinomas, 7 of whom died of recurrence. The PG-I values became elevated with recurrence in 5 of them and the values increased with the passage of time. In contrast, no substantial changes in PG-I levels occurred in patients with no recurrence. These results suggest that PG-I is useful for the early detection of recurrent disease after total gastrectomy in patients with PG-I-producing gastric carcinomas.

Are Gastric Cancer Resection Margin Proteomic Profiles More Similar to Those from Controls or Tumors?

“…Some studies report the association of pepsinogen expression with preneoplastic and neoplastic changes of the stomach mucosa, as well as its significance in cases of gastric cancer, especially to screening as a predictor, irrespective of H. pylori infection. , Another study suggests that the pepsinogen group I is useful for the early detection of recurrent gastric cancer, as it was observed that the values of pepsinogen become elevated with the recurrence and increase with time. On the other hand, in patients with no recurrence, the levels of this protein does not demonstrate a substantial difference …”

“…On the other hand, in patients with no recurrence, the levels of this protein does not demonstrate a substantial difference. 25 Collagen Alpha-1 (COL11A1). Collagen is a protein that acts in cell adhesion and is found in the extracellular matrix.…”

PG I and PG II show unique value in diagnosing postoperative biochemical recurrence in patients with gastric cancer after total gastrectomy

“…Although the physiological role of PG as a digestive enzyme has been recognized for many years, previous research, dating back more than three decades [ 29 ], was constrained by the limitations of the detection methods at that time, such as radioimmunoassay (RIA). These methodological constraints primarily hindered the study of PG for the diagnosis of gastric cancer biochemical recurrence, and there were no parallel investigations into the relevance of PG II.…”