Growth differentiation factor 15 (GDF-15) in kidney diseases

Delrue, Charlotte; Speeckaert, Reinhart; Delanghe, Joris; Speeckaert, Marijn M.

doi:10.1016/bs.acc.2023.02.003

Cited by 10 publications

(6 citation statements)

References 132 publications

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“…The role of GDF-15 presents potential renal protective effects in kidney disease and injury, especially during inflammation, injury, and recovery. 97 It is shown that the loss of GDF-15 enhances the inflammatory response, which is harmful for lipopolysaccharide-induced (LPS-induced) kidney and heart damage, while overexpression of GDF-15 improves LPS-induced organ dysfunction. 98 In addition, GDF-15 is related to early renal protective injury responses by altering the behavior of immune cells, such as T cells.…”

Section: The Role Of Gdf-15 In the Kidney Diseasesmentioning

confidence: 99%

Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease

Tang,

Liu,

Sun

et al. 2024

JIR

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GDF-15 is an essential member of the transforming growth factor-beta superfamily. Its functions mainly involve in tissue injury, inflammation, fibrosis, regulation of appetite and weight, development of tumor, and cardiovascular disease. GDF-15 is involved in various signaling pathways, such as MAPK pathway, PI3K/AKT pathway, STAT3 pathway, RET pathway, and SMAD pathway. In addition, several factors such as p53, ROS, and TNF-α participate the regulation of GDF-15. However, the specific mechanism of these factors regulating GDF-15 is still unclear and more research is needed to explore them. GDF-15 mainly improves the function of kidneys in CKD and plays an important role in the prediction of CKD progression and cardiovascular complications. In addition, the role of GDF-15 in the kidney may be related to the SMAD and MAPK pathways. However, the specific mechanism of these pathways remains unclear. Accordingly, more research on the specific mechanism of GDF-15 affecting kidney disease is needed in the future. In conclusion, GDF-15 may be a therapeutic target for kidney disease.

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Section: The Role Of Gdf-15 In the Kidney Diseasesmentioning

confidence: 99%

Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease

Tang,

Liu,

Sun

et al. 2024

JIR

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“…Growth differentiation factor-15 (GDF-15) is a protein belonging to the GDF subfamily of the transforming growth factor-β (TGF-β) superfamily [159,160]. It is naturally present in cells of the cardiovascular, immune, and renal systems.…”

Section: Plasma Growth Differentiation Factor 15 (Gdf-15)mentioning

confidence: 99%

“…It is naturally present in cells of the cardiovascular, immune, and renal systems. In typical physiological conditions, the placenta is the main organ that secretes a substantial amount of GDF-15, especially during the third trimester [159,161]. Overexpression of GDF-15 occurs in response to pathophysiological processes such as inflammation, ischemia, and mechanical or oxidative stress.…”

Section: Plasma Growth Differentiation Factor 15 (Gdf-15)mentioning

confidence: 99%

“…Multiple studies have indicated a positive correlation between plasma GDF-15 levels and the incidence of CKD. This correlation is partly attributed to the increased level of GDF-15 in the kidneys, serving as a protective response against early-stage kidney damage [159]. Notably, data from the Framingham Offspring study, involving 2614 participants observed over a follow-up of approximately 9 years, revealed a significant association between high levels of GDF-15 and the incidence of CKD as well as a rapid decline in GFR [93].…”

Section: Plasma Growth Differentiation Factor 15 (Gdf-15)mentioning

confidence: 99%

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Chronic Kidney Disease Associated with Ischemic Heart Disease: To What Extent Do Biomarkers Help?

Cepoi,

Duca,

Chetran

et al. 2023

Life

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Chronic kidney disease represents a complex and multifaceted pathology characterized by the presence of structural or functional renal anomalies associated with a persistent reduction in renal function. As the disease progresses, complications arise due to the chronic inflammatory syndrome, hydro-electrolytic disorders, and toxicity secondary to the uremic environment. Cardiovascular complications are the leading cause of death for these patients. Ischemic cardiac pathology can be both a consequence and complication of chronic kidney disease, highlighting the need to identify specific cardiorenal dysfunction biomarkers targeting pathophysiological mechanisms common to both conditions. This identification is crucial for establishing accurate diagnoses, prognoses, and risk stratifications for patients. This work is intended to elucidate the intricate relationship between chronic kidney disease and ischemic heart disease and to investigate the roles of cardiorenal biomarkers, including cardiac troponin, natriuretic peptides, galectin-3, copeptin, fibroblast growth factor 23 and its co-receptor Klotho, soluble suppression of tumorigenicity 2, and plasma growth differentiation factor 15.

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“…GDF-15 expression is often induced under stress conditions to maintain cell and tissue homeostasis. Increased GDF-15 levels are associated with pathologic conditions such as inflammation, infection, tissue injury, and liver, kidney, cardiovascular diseases, and cancers ( Wischhusen et al, 2020 ; Delrue et al, 2023 ; Losch et al, 2023 ; Merchant et al, 2023 ; Morita-Tanaka et al, 2023 ; Teawtrakul et al, 2023 ). GDF-15 has thus been widely explored as a biomarker for disease prognosis.…”

Section: Introductionmentioning

confidence: 99%

Circulating GDF-15: a biomarker for metabolic dysregulation and aging in people living with HIV

Wang,

Zhao,

Schank

et al. 2024

Front. Aging

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Despite effective control of HIV replication by antiretroviral therapy (ART), a significant number of people living with HIV (PLWH) fail to achieve complete immune reconstitution and thus are deemed immune non-responders (INRs). Compared with immune responders (IRs) who have restored their CD4 T cell numbers and functions, CD4 T cells from these INRs exhibit prominent mitochondrial dysfunction and premature aging, which play a major role in increasing the incidence of non-AIDS, non-communicable diseases (NCDs). To date, there are no reliable biomarkers that can be used to typify and manage PLWH, especially INRs with non-AIDS NCDs. Growth differential factor-15 (GDF-15) is a transforming growth factor-β (TGF-β) family member known to regulate several biological processes involved in cell aging and stress responses. Since PLWH exhibit premature aging and metabolic dysregulation, here we measured the plasma levels of GDF-15 by ELISA and metabolic proteins by proteomic array and correlated the results with clinical parameters in ART-controlled PLWH (including INRs and IRs) and healthy subjects (HS). We found that GDF-15 levels were significantly elevated in PLWH compared to HS. GDF-15 levels were positively correlated with age and negatively associated with body mass and LDL cholesterol levels in the study subjects. Also, elevated GDF-15 levels were correlated with differential dysregulation of multiple metabolic proteins in PLWH. These results suggest that GDF-15 protein may serve as a biomarker of metabolic dysregulation and aging, and this biomarker will be useful in clinical trials targeting aging and metabolic disorders in ART-treated PLWH.

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Growth differentiation factor 15 (GDF-15) in kidney diseases

Cited by 10 publications

References 132 publications

Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease

Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease

Chronic Kidney Disease Associated with Ischemic Heart Disease: To What Extent Do Biomarkers Help?

Circulating GDF-15: a biomarker for metabolic dysregulation and aging in people living with HIV

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