2020
DOI: 10.22541/au.159741606.68337185
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Growth differentiation factor 15 levels in obese and healthy pregnancies and its relation to insulin resistance and insulin secretory function: a longitudinal study during and after pregnancy

Abstract: Objective/aim Growth-differentiation-factor 15 (GDF15) has been suggested to improve or protect beta-cell function. During pregnancy, beta-cell numbers and function increase to overcome the natural rise in insulin resistance during gestation. In this study, we longitudinally measured serum GDF15 levels during and after pregnancy in women of normal weight (NW) and in women with obesity (OB) and explored associations between GDF15 and changes in beta-cell function by homeostatic model assessment (HOMA). Methods … Show more

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