Growth Factors in Bladder Wound Healing

Baskin, Laurence S.; Sutherland, Ronald S.; Thomson, Axel A.; Nguyen, Heip-Thieu; Morgan, Daniel M.; Hayward, Simon W.; Hom, Yun K.; DiSandro, Michael; Cunha, Gerald R.

doi:10.1097/00005392-199706000-00119

Cited by 24 publications

(40 citation statements)

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“…Interestingly, no difference in the extent of UVB damage was seen in these mice in the absence of exogenous KGF. This finding is consistent with our result that -in contrast to many other situations where KGF expression is upregulated upon epithelial injury (Werner et al, 1992;Zeeh et al, 1996;Baskin et al, 1997;Charafeddine et al, 1999;Adamson and Bakowska, 1999) -enhanced KGF expression upon UV irradiation could be detected neither in murine skin nor in cultured fibroblasts (our unpublished data).…”

Section: Discussionsupporting

confidence: 93%

Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents

Braun

Krampert²,

Bodó

et al. 2006

Journal of Cell Science

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Owing to its potent cytoprotective properties for epithelial cells, keratinocyte growth factor (KGF) is successfully used for the treatment of chemotherapy- and radiotherapy-induced oral mucositis in cancer patients. It is therefore of major interest to determine possible clinical applications of KGF in other organs and in different stress situations and to unravel common and organ-specific mechanisms of KGF action. Here we show that KGF protects human keratinocytes from the toxicity of xenobiotics with electrophilic and oxidative properties and reduces the cell death induced by UV irradiation. In contrast to other cell types, cytoprotection of keratinocytes by KGF is not a direct anti-apoptotic effect but requires de novo protein synthesis. The in vitro findings are clinically relevant because KGF protected keratinocytes in organ-cultured human scalp hair follicles from the toxicity of the xenobiotic menadione. Moreover, injection of KGF into murine back skin markedly reduced cell death in the epidermis after UVB irradiation. This activity is dependent on FGF receptor signaling because it was abrogated in transgenic mice expressing a dominant-negative FGF receptor mutant in keratinocytes. Taken together, our results encourage the use of KGF for skin protection from chemical and physical insults.

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Section: Discussionsupporting

confidence: 93%

Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents

Braun

Krampert²,

Bodó

et al. 2006

Journal of Cell Science

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“…For instance, Chung et al reported a 3.2-4.5-fold increase in proliferation of limbal and peripheral cells after creation of a 3-mm wound in the cornea [18]. Baskin et al detected a six-to eightfold increase in transcription of keratinocyte growth factor and transforming growth factor alpha in full-thickness bladder tissue in vivo,12-24 h after the creation of surgical wounds in rat bladders [19], although actual changes in proliferation in response to wounding were not examined during this study. In both these cases, fully differentiated tissue was used and the wounds were significantly larger than the 500-800-m wounds considered here.…”

Section: Discussionmentioning

confidence: 99%

Agent-Based Computational Modeling of Wounded Epithelial Cell Monolayers

Walker

Hill

Wood

et al. 2004

IEEE Trans.on Nanobioscience

142

108

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ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. Index Terms-Calcium, computational modeling, emergent structure, urinary epithelium, wound healing.

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“…The FGFR2-IIIb signaling pathway can lead to mitogenesis, as is the case for basal cells of the skin or bladder wound healing, 35,36 and progression of tumors, as in poorly differentiated carcinomas of the stomach. 37,38 Alternatively, the same receptor may be implicated in the control of cell differentiation, as in the suprabasal cells of the skin 39 and in the maintenance of certain carcinomas in less aggressive forms as in this study and others.…”

Section: Tumorigenicity Of Fgfr2-iiib Re-expressing Hcc Cells In Vivomentioning

confidence: 99%

Reduced Expression of Fibroblast Growth Factor Receptor 2IIIb in Hepatocellular Carcinoma Induces a More Aggressive Growth

Amann

Bataille

Spruß

et al. 2010

The American Journal of Pathology

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Growth Factors in Bladder Wound Healing

Cited by 24 publications

References 0 publications

Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents

Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents

Agent-Based Computational Modeling of Wounded Epithelial Cell Monolayers

Reduced Expression of Fibroblast Growth Factor Receptor 2IIIb in Hepatocellular Carcinoma Induces a More Aggressive Growth

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