Growth factors in bone

Solheim, Eirik

doi:10.1007/s002640050290

Cited by 171 publications

(100 citation statements)

References 72 publications

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“…These large molecules direct cellular activity by binding to specific transmembrane cell receptors which subsequently triggers the intracellular domain and activates transcription of a gene into mRNA and consequently protein production. An excellent review of physiological roles and in vitro/in vivo analysis of growth factors is provided by Solheim et al 161 The motivation for utilizing these factors in synthetic bone scaffolds is established by the fact that in normal bone physiology, osteoprogenitor proliferation, migration into osseous tissue, and differentiation into osteoblasts (osteoconduction) occur under the influence of growth and transcription factors. For example, the osteoblast secreted transcription factor Cbfa-1/Runx-2 plays key roles in bone remodeling and is required for the expression of osteoblast-specific genes and proteins, such as osteocalcin.…”

Section: Chemical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Chemical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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“…The most common osteogenic growth factors used for biomedical purposes are the members of the TGF-β superfamily, including the BMP family (126). In particular BMP-2, BMP-7 and TGF-β1 are promising growth factors for enhanced bone formation around the implant (127)(128)(129)(130)(131)(132)(133). Growth factors can be adsorbed or covalently bound to the titanium surface (129,134), but are commonly added to CaP or collagen-coated implants (103,132,(135)(136)(137).…”

Section: Growth Factor Immobilizationmentioning

confidence: 99%

“…Bone regeneration around implants can be strongly enhanced by immobilizing growth factors such as bone morphogenetic protein (BMP), transforming growth factorbeta (TGF-β), fibroblast growth factor (FGF), plateletderived growth factor (PDGF), and insulin-like growth factor (IGF) to the titanium surface (Table IV) (125)(126)(127). The most common osteogenic growth factors used for biomedical purposes are the members of the TGF-β superfamily, including the BMP family (126).…”

Section: Growth Factor Immobilizationmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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“…O PRP tem larga aplicação clínica na área de cirurgia bucomaxilofacial, sendo utilizado como agente osteopromotor em diversas situações (31)(32)(33) . A sua utilização clínica em ortopedia vem crescendo, a despeito da ausência de estudos prospectivos e randomizados que avaliem os resultados de sua aplicação (30,(34)(35)(36) . Em um estudo que se propõe a avaliar a eficácia do PRP isolado ou em associação com outros materiais, é importante lembrar que diversos são os métodos utilizados na obtenção do PRP (1,5,30) , e que a capacidade em obter altas concentrações de plaquetas é variável entre os métodos disponíveis.…”

Section: Discussionunclassified

O uso do plasma rico em plaquetas associado ao aspirado de medular óssea na osteotomia tibial tipo puddu

D’Elia¹,

Rezende²,

Bitar³

et al. 2009

Rev. bras. ortop.

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rESUMOObjetivo: O presente estudo procurou avaliar a aplicação do plasma rico em plaquetas associado ao aspirado de medular ós-sea como substituto ósseo ao enxerto autólogo do ilíaco nas osteotomias tibiais proximais de cunha de adição medial (OTCAM). Métodos: Foram estudados 25 pacientes submetidos a OTCAM divididos de forma randomizada em dois grupos, grupo ilíaco, 14 pacientes submetidos a OTCAM nos quais se utilizou o enxerto autólogo do ilíaco para preencher o sitio da osteotomia, grupo PRP, 11 pacientes submetidos a OTCAM nos quais se utilizou um composto formado por plasma rico em plaquetas associado ao aspirado de medular ósseo para preencher o sitio da osteotomia. Foram avaliados o sangramento (variação dos níveis de hemoglobina e hematócrito) e a dor (escala visual analógica -EVA), comparando os grupos em relação a essas variáveis. Resultados: Não foram observadas diferenças entre os grupos no que se refere à variação dos níveis de hemoglobina (p = 0,820) e hematócrito (p = 0,323). Os grupos não foram diferentes em relação à intensidade da dor segundo a EVA (p = 0,538). Conclusão: O uso do PRP associado ao aspirado de medular óssea nas OTCAM não demonstrou vantagem sobre a utilização do enxerto autólogo do ilíaco no que se refere a dor e sangramento.

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Growth factors in bone

Cited by 171 publications

References 72 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

O uso do plasma rico em plaquetas associado ao aspirado de medular óssea na osteotomia tibial tipo puddu

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