Growth Hormone and Prolactin Secretion after Metoclopramide Administration (DA2 Receptor Blockade) in Fertile Women*

Abstract

In this report, we will describe the results of a cross-sectional study to assess PRL and GH secretion during the early follicular phase in 22 fertile patients after metoclopramide administration in order to achieve a dopaminergic DA2 receptor blockade. Blood samples were collected at - 15, 0, 15, 30, 45 and 60 minutes. PRL, GH, estradiol, IGF-I, TSH, glucose, and insulin were measured in the samples taken at - 15 and 0 minutes. The existence of a correlation between GH and PRL secretion was investigated. All patients presented normal serum levels of estradiol, prolactin, insulin, fasting glucose and IGF-I. Serum GH levels were not changed after metoclopramide infusion (p = 0.302), but there was a significant alteration in serum PRL (p = 0.0001) with the highest levels after 30 (mean: 237.20 ng/ml +/- 95.86) and 45 (mean: 211.80 ng/ml +/- 83.24) minutes. Serum GH levels did not correlate with serum PRL levels after the dopaminergic DA2 blockade. We conclude that GH secretion was not modulated by a direct effect of type 2 dopamine receptor.

Follicular fluid concentration of soluble Human-G Leukocytic Antigen (sHLA-G) in in vitro fertilization cycles of women with and without peritoneal endometriosis

“…Endometriosis is a heterogeneous disease associated with infertility and one of the main causes of IVF. Furthermore, several mechanisms involving granulosa cells were described for this group of patients, involving prolactin secretion, decreased anti-Mullerian hormone and dysfunction in BMP-6 and SMAD4 in cumulus cells linked to peritoneal endometriosis ( Cunha-Filho et al. , 2001 ; 2003 ; De Conto et al, 2017 ; 2020).…”

“…Endometriosis is a heterogeneous disease associated with infertility and one of the main causes of IVF. Furthermore, several mechanisms involving granulosa cells were described for this group of patients, involving prolactin secretion, decreased anti-Mullerian hormone and dysfunction in BMP-6 and SMAD4 in cumulus cells linked to peritoneal endometriosis (Cunha-Filho et al, 2001;2003;De Conto et al, 2017;. Nowadays the effect of endometriosis during an IVF cycle is disputed and has recently been questioned by several authors, but it is essential to understand the role of this disease during the IVF process to enhance pregnancy rates (Opøien et al, 2012;Barbosa et al, 2014;González-Comadran et al, 2017;Caran et al, 2021).…”

Reducing adverse events associated with the glucagon stimulation test for the assessment of growth hormone deficiency in adults with a high prevalence of pituitary hormone deficiencies

“…Data on the effect of metoclopramide on GH secretion are mixed. Two previous studies have shown no impact on GH levels post‐metoclopramide, 22,23 whilst two other studies report metoclopramide may stimulate GH secretion including one study of adolescent males of short stature 24 and another in patients with diabetes mellitus on insulin therapy 25 . However, the exact mechanism for this proposed stimulation in both studies was unclear.…”

Prolactin promotes proliferation of germinal center B cells, formation of plasma cells, and elevated levels of IgG3 anti-dsDNA autoantibodies

“…It will be interesting to study whether other hormones that have been associated with SLE activity and whose secretion is also induced by metoclopramide, such as growth hormone ( 36 , 37 ), and estrogens ( 38 , 39 ) could also influence the formation of GC.…”