Growth hormones. 1. Polymorphism. (Minireview)

Charrier, J.; Martal, J.

doi:10.1051/rnd:19880601

Cited by 29 publications

(18 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…hGH from Cis International France). All known immunoreactive forms of GH [8][9][10] are recog-nized by this antibody. The lower limit of sensitivity of the assay was 0.5 mIU/1 with intra-and interassay coefficients of variation of 5.3 and 11%.…”

Section: Methodsmentioning

confidence: 99%

Pulsatility of Growth Hormone Secretion and its Relation to Growth

Weill

Duhamel²,

d’Herbomez³

et al. 1992

Horm Res

View full text Add to dashboard Cite

84 short children were submitted to nocturnal spontaneous growth hormone (GH) secretion tests and to provocative insulin-arginine tests. Discrepancies between the GH peak under the provocative test (I-AP) and nocturnal GH maximal peak (PA) and mean concentration (MC) were frequently observed, despite significant statistical correlation between I-AP and PA (r = 0.47; p < 0.02) and between I-AP and MC (r = 0.42; p < 0.02). Night profiles were evaluated by time analysis: 31 fitted a theoretical model, consisting of a cosine function of time (modelizable profiles). Spectral analysis, from Fourier transformation, indicated predominant periods after cluster analysis. The major predominant period in modelizable (n = 9) and in nonmodelizable (n = 28) profiles was close to 180 min and a secondary period was on average 122 min in modelizable (n = 20) and 105 min in nonmodelizable (n = 23) profiles. Two modelizable and two nonmodelizable profiles escaped this classification. The general, auxological and GH secretory status did not differ significantly between patients with modelizable and nonmodelizable profils. Growth velocity correlated with GH mean concentration (r = 0.36; p < 0.001), but not with plasma insulin-like growth factor-I levels nor with any of the pulsatility indices: number of peaks, main period, and pulse height index = mean GH peak/mean GH concentration. The relevance of GH pulsatility to growth is, therefore, unclear in humans.

show abstract

Section: Methodsmentioning

confidence: 99%

Pulsatility of Growth Hormone Secretion and its Relation to Growth

Weill

Duhamel²,

d’Herbomez³

et al. 1992

Horm Res

View full text Add to dashboard Cite

show abstract

“…Duplication of the GH gene was first discovered in primates but further investigation indicated that this event had also occurred in rats, pigs, goats, sheep and cattle (Charrier and Martal, 1988;Wallis et al, 1998). In cattle the two major allelic variants of GH, denoted A (leucine at position 127) and B (valine at position 127), have been identified by Lucy et al, 1993).…”

Section: Basic Physiology Nutritional Factors Influencing Thyroid Fumentioning

confidence: 99%

Clinical endocrinology of thyroid gland function in ruminants

Huszenicza¹,

Kulcsár²,

Rudas³

2002

Vet. Med.

View full text Add to dashboard Cite

After briefly introducing the basec steps in production and metabolism of thyroid hormones, the author gives an overview of nutritional, metabolic and disease related factors and endocrine interactions influencing thyroid gland function in ruminants, particularly in the postpartum dairy cow. Involvement of thyroid hormonal regulation of seasonal patterns of reproduction as well as ovarian endocrine function are discussed.Keywords: thyroxin; triiodothyronine; ovary; metabolism; ruminants Abbreviations: 5'D = 5'-deiodinase (syn.: outer-ring deiodinase); 5D = 5-deiodinase (syn.: inner-ring deiodinase); BHB = βOH-butyrate; E 2 = 17β-estradiol; FSH = follicle stimulating hormone; GH = growth hormone; GnRH = gonadotropin releasing hormone; hCG = human chorionic gonadotropin; IGF-I = insulin-like growth factor-I (syn.: somatomedin C); IL = interleukin; LH = luteinizing hormone; mRNA = messenger ribonucleic acid; NEB = negative energy balance; NEFA = non-esterified fatty acids; P 4 = progesterone; PVN = paraventricular nucleus of the hypothalamus; rT 3 = 3,3',5'-triiodothyronine (syn.: reverse-triiodothyronine); T 3 = 3,3',5-triiodothyronine; T 4 = thyroxine; TNFα = tumor necrosis factor-α; TRH = thyrotropin-releasing hormone; TSH = thyroid-stimulating hormone (syn.: thyrotropin)

show abstract

“…hGH-N gene encodes for the sequence of the major form of hGH, the 22K, as well as the subsequent forms that are derived from it (see &dquo;Growth Hormone. I. Polymorphism&dquo;; Charrier and Martal, 1988) including the 20K variant from an alternative splicing of premessenger RNA (Wallis, 1980;De Noto et al, 1981), and a new natural 17.5K variant (Lecomte et al, 1987 (Frigeri et al, 1979;Kostyo et al, 1985). The second hGH-V gene seems to encode for a polypeptide of 191 amino acids experimentally transcribed in vitro, in which 13 amino acids differ from the 22K of hGH (Pavlakis et al, 1981).…”

Section: Genomic Modifications Hgh Genesmentioning

confidence: 99%

“…The criteria used to define biological activities are based on the well known multiple action of GHs (see &dquo;Growth Hormones. I. Polymorphism&dquo;; Charrier and Martal, 1988, Tables II and III).…”

Section: Introductionmentioning

confidence: 99%