Growth of Head and Neck Squamous Cell Carcinoma in Nude Mice: Potentiation of Laryngeal Carcinoma by 17beta-Estradiol

Somers, Kenneth D.; Koenig, Mark; Schechter, Gary L.

doi:10.1093/jnci/80.9.688

Cited by 29 publications

(14 citation statements)

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“…All mice were implanted subcutaneously with 60-day release hormone pellets (Innovative Research of America, Toledo, OH) that contained 0.5 mg 17␤-estradiol (E2) (n ϭ 6) or placebo vehicle alone (n ϭ 6). This estradiol dosage was shown to yield serum estrogen concentrations within the physiological range (46). One week after surgery, mice were fed for 6 wk on the HFHC diet [OVX-HFHC group (n ϭ 6), OVX-HFHCϩE2 group (n ϭ 6)].…”

Section: Methodsmentioning

confidence: 99%

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

Kamada

Kiso

Yoshida

et al. 2011

American Journal of Physiology-Gastrointestinal and Liver Physi

137

101

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Recent studies indicate an accelerated progression of nonalcoholic steatohepatitis (NASH) in postmenopausal women. Hypercholesterolemia, an important risk factor for NASH progression, is often observed after menopause. This study examined the effects of estrogen on NASH in ovariectomized (OVX) mice fed a high-fat and high-cholesterol (HFHC) diet. To investigate the effects of estrogen deficiency, OVX mice and sham-operated (SO) mice were fed normal chow or HFHC diet for 6 wk. Next, to investigate the effects of exogenous estrogen replenishment, OVX mice fed with HFHC diet were treated with implanted hormone release pellets (containing 17β-estradiol or placebo vehicle) for 6 wk. OVX mice on the HFHC diet showed enhanced liver injury with increased liver macrophage infiltration and elevated serum cholesterol levels compared with SO-HFHC mice. Hepatocyte monocyte chemoattractant protein-1 (MCP1) protein expression in OVX-HFHC mice was also enhanced compared with SO-HFHC mice. In addition, hepatic inflammatory gene expressions, including monocytes chemokine (C-C motif) receptor 2 (CCR2), were significantly elevated in OVX-HFHC mice. Estrogen treatment improved serum cholesterol levels, liver injury, macrophage infiltration, and inflammatory gene expressions in OVX-HFHC mice. Moreover, the elevated expression of liver CCR2 and MCP1 were decreased by estrogen treatment in OVX-HFHC mice, whereas low-density lipoprotein dose dependently enhanced CCR2 expression in THP1 monocytes. Our study demonstrated that estrogen deficiency accelerated NASH progression in OVX mice fed HFHC diet and that this effect was improved by estrogen therapy. Hypercholesterolemia in postmenopausal women would be a potential risk factor for NASH progression.

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Section: Methodsmentioning

confidence: 99%

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

Kamada

Kiso

Yoshida

et al. 2011

American Journal of Physiology-Gastrointestinal and Liver Physi

137

101

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“…HNSCC tumors express ERs, although with variable results reported in the literature. Exogenous estrogen has been shown to stimulate HNSCC proliferation and invasion in vitro 77 and to increase tumor growth in mice 78 . Similar to lung cancer, estrogen has been shown to induce both genomic (transcriptional responses) as well as non-genomic (rapid P-MAPK signaling) in HNSCC 77 .…”

Section: Estrogen Receptors In Other Non-reproductive Malignanciesmentioning

confidence: 99%

Estrogenic Steroid Hormones in Lung Cancer

Siegfried

Stabile

2014

Seminars in Oncology

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It is becoming increasingly clear that steroid hormones are involved in the biology of many organs outside the reproductive system. Evidence has been accumulating since the mid-1990’s that the lung contains receptors for both estrogen and progesterone and that these hormones have some role in lung development, pulmonary inflammation, and lung cancer. The estrogen receptor β (ERβ) is the major ER expressed in lung tissues, while inflammatory cells capable of infiltrating the lung are reported to express both ERα and ERβ. Although there is evidence in animals of preferential effects of ERβ in the lungs of females, human lung tumors from males also contain ERβ positive cells and express aromatase, the enzyme that converts testosterone to estrogens. This review will discuss current literature findings on the role of the ERs and the progesterone receptor (PR) as well CYP19 (aromatase), the rate-limiting enzyme in the synthesis of estrogen, in lung cancer.

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“…Thyroid cancer is also well coupled with estrogen. [10] The results demonstrate that estradiol treatment potentiates growth of laryngeal tumors in nude mice [11].…”

Section: Discussionmentioning

confidence: 92%

Apoptosis in Colon Cancer (HT29) Cells Exposed to Estradiol Valerat

2017

Dec. 4-6, 2017 London (UK) ICEEET-2017, ICABES-2017, ICCATE-2017, ICLSSE-17 &Amp; LBMCSR-2017

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Growth of Head and Neck Squamous Cell Carcinoma in Nude Mice: Potentiation of Laryngeal Carcinoma by 17beta-Estradiol

Cited by 29 publications

References 0 publications

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

Estrogenic Steroid Hormones in Lung Cancer

Apoptosis in Colon Cancer (HT29) Cells Exposed to Estradiol Valerat

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