Growth Pattern, an Important Pathologic Prognostic Parameter for Clear Cell Renal Cell Carcinoma

Abstract

Growth pattern can be considered a new prognostic parameter for ccRCC.

Relationship of Pathologic Factors to Efficacy of Sorafenib Treatment in Patients With Metastatic Clear Cell Renal Cell Carcinoma

“…Recently, we reported that the infiltrating pattern was related to poor clinical outcomes in patients with CCRCC. 13,14 In the present study, we further demonstrated that this new pathologic parameter is prognostic for patients treated with sorafenib. We observed an 8.7-month median duration of PFS in patients with an expansive pattern, which was considerably longer than the 1.7-month median PFS in patients with an infiltrating pattern.…”

“…13,14 However, no studies have investigated whether growth pattern could be used to predict the outcomes of patients with CCRCC who are receiving TKIs. Accordingly, we have retrospectively investigated the set of pathologic parameters that may be predictive of response rates and PFS in cases of metastatic CCRCC that are treated with sorafenib.…”

“…Recently, growth pattern has been proposed as a novel pathologic prognostic factor for CCRCC. 13,14 In brief, the presence of an "expansive pattern" was defined as a wellcircumscribed tumor margin without the presence of normal renal tissue in the tumor, and the presence of an "infiltrating pattern" was defined as an ill-circumscribed tumor margin with cancer cells that were extensively infiltrating normal renal tissues ❚Image 1❚. 14 All cases were defined as having either an expansive pattern or an infiltrating pattern.…”

Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas–Renal Cell Carcinoma (TCGA–RCC) Imaging Research Group

“…We found that an ill-defined tumor margin and tumor calcification each were associated with the BAP1 mutation. An ill-defined margin has been associated with locally infiltrative and overall aggressive ccRCC [5, 33, 34]. The BAP1 mutation, found in 15% of ccRCC, is known to be associated with high-grade tumors (Fuhrman grade 3 or 4) and poor survival [5, 13].…”

Tumor Enucleation for Sporadic Localized Kidney Cancer: Pro and Con

“…In the final analysis, the success of TE in most of the recent series likely reflects the inherent tumor biology of cT1 RCC, which typically demonstrates expansive growth pattern rather than infiltration. 12 In summary, TE is a contemporary approach to sporadic RCC in the era of maximal nephron preservation. TE allows for equivalent oncologic control, enhanced surgical precision and the potential for fewer intraoperative complications, and may obviate the need for warm ischemia and complex renorrhaphy.…”