2022
DOI: 10.21203/rs.3.rs-1462784/v1
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GSDMD-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

Abstract: Dysregulated inflammation is closely associated with increased mortality in sepsis. Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, including the development of thrombosis, thrombocytopenia, and neutrophil extracellular traps (NETs). Platelet’s contributions to rapid clinical deterioration and dysregulated inflammation in sepsis have not been defined. In our cohort, the incidence of thrombocytopenia, thrombocytopathy and excessive inflammatory cytokines released in patie… Show more

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