GST genetic polymorphisms and lung adenocarcinoma susceptibility in a Chinese population

Wang, Jingwen; Deng, Yifu; Cheng, Jinglei; Ding, Jian; Tokudome, Shinkan

doi:10.1016/s0304-3835(03)00480-4

Cited by 81 publications

(52 citation statements)

References 42 publications

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“…Six studies evaluating GSTM1, GSTT1, and GSTP1 genotypes and their association with risk of lung cancer met the inclusion criteria for the meta-analysis [41][42][43][44][45][46]. Table 1 provides a summary of each gene's name and chromosomal location.…”

Section: Resultsmentioning

confidence: 99%

“…The papers were then reviewed to identify casecontrol studies in Asian populations. A total of 11 case-control studies [36][37][38][39][40][41][42][43][44][45][46] were found. Five studies [36][37][38][39][40] were excluded because there was no exposure assessment and no evidence provided in the study that indoor air pollution from any source made an important contribution to lung cancer.…”

Section: Methodsmentioning

confidence: 99%

“…Five studies [36][37][38][39][40] were excluded because there was no exposure assessment and no evidence provided in the study that indoor air pollution from any source made an important contribution to lung cancer. The remaining 6 studies [41][42][43][44][45][46] satisfied all inclusion criteria, and data related to study design, geographic location, population setting, case selection, control selection, genotyping method, Hardy-Weinberg equilibrium, type of exposure, exposure assessment, smoking, and number of genotyped cases and controls were extracted.…”

Section: Methodsmentioning

confidence: 99%

“…Overall, one study utilized a quantitative exposure assessment [41], one a qualitative exposure assessment [42], and the presence of indoor air pollution was determined for four studies [43][44][45][46]. Lan et al's [41] study was in Xuan Wei, where more than 95% of the population was exposed to coal and a substantial portion of lung cancer has been attributed to indoor coal use [14;47].…”

Section: Methodsmentioning

confidence: 99%

“…Similarly more than 95% of the population in the Shenyang study reported by Yang et al [45] was also exposed to coal [45;48], and epidemiologic studies have shown that coal exposure is associated with increased risk of lung cancer in Shenyang [49][50][51]. Approximately 80% of the population in Changsha City in the Hunan study for nonsmoking lung cancer cases and controls by Chen et al [43] were exposed to coal up until 1997 (Han-chun Chen, personal communication), and about 80% of the population in the Beijing study by Wang et al [46] used coal in their homes (Jingwen Wang, personal communication). Although formal risk estimates have not been published for coal use and lung cancer in these two studies, it is highly likely that this exposure is associated with risk of lung cancer [17].…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis

Hosgood

Berndt

Lan

2007

Mutation Research/Reviews in Mutation Research

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About half of the world's population is exposed to smoke from heating or cooking with coal, wood, or biomass. These exposures, and fumes from cooking oil use, have been associated with increased lung cancer risk. Glutathione S-transferases play an important role in the detoxification of a wide range of human carcinogens in these exposures. Functional polymorphisms have been identified in the GSTM1, GSTT1, and GSTP1 genes, which may alter the risk of lung cancer among individuals exposed to coal, wood and biomass smoke and cooking oil fumes. We performed a meta-analysis of six published studies (912 cases; 1063 controls) from regions in Asia where indoor air pollution makes a substantial contribution to lung cancer risk, and evaluated the association between the GSTM1 null, GSTT1 null, and GSTP1 105Val polymorphisms and lung cancer risk. Using a random effects model, we found that carriers of the GSTM1 null genotype had a borderline significant increased lung cancer risk (odds ratio (OR), 1.31; 95% confidence interval (CI), 0.95-1.79; p=0.100), which was particularly evident in the summary risk estimate for the four studies carried out in regions of Asia that use coal for heating and cooking (OR, 1.64; 95%CI, 1.25-2.14; p=0.0003). The GSTT1 null genotype was also associated with an increased lung cancer risk (OR, 1.49; 95%CI, 1.17-1.89; p=0.001), but no association was observed for the GSTP1 105Val allele. Previous meta-and pooled-analyses suggest at most a small association between the GSTM1 null genotype and lung cancer risk carried out in populations where the vast majority of lung cancer is attributed to tobacco, and where indoor air pollution from domestic heating and cooking is much less than in developing Asian countries. Our results suggest that the GSTM1 null genotype may be associated with a more substantial risk of lung cancer in populations with coal exposure.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis

Hosgood

Berndt

Lan

2007

Mutation Research/Reviews in Mutation Research

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Glutathione S-Transferase Polymorphisms and Risk of Differentiated Thyroid Carcinomas

Zhao

Zheng³

et al. 2006

Arch Otolaryngol Head Neck Surg

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GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population

Palli

Saieva

Gemma

et al. 2005

Intl Journal of Cancer

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Glutathione S-Transferases (GSTs) are a family of phase II enzymes involved in the detoxification of potential carcinogens and provided of a strong antioxidant function by neutralizing electrophiles and free radicals. The GSTM1 and GSTT1 isoenzymes exhibit deletion polymorphisms, resulting in a lack of activity, and the null genotypes have been associated with increased cancer risk at several sites, including the stomach, although with contrasting results. We carried out a case-control study to evaluate whether these polymorphisms modulate the risk of developing gastric cancer (GC). Genotypes for GSTM1 and GSTT1 were obtained from a series of 175 histologically confirmed GC patients and a large series of 546 healthy controls randomly sampled from the general population of Tuscany, an area at high GC risk. No difference in the frequency of GSTM1 null genotype was observed between cases and controls, whereas the GSTT1 null genotype was more frequent among cases (p ¼ 0.04). Multivariate single-gene analyses adjusted for possible confounders showed that the GSTT1 null genotype, but not the GSTM1 null genotype, was associated with an increased GC risk. Combined-genotype analyses showed a significantly increased GC risk only for the double null (GSTM1-GSTT1) genotype (OR ¼ 2.27; 95% CI: 1.14-4.53). A statistically significant positive interaction between the 2 null genotypes was observed (p ¼ 0.02). Our findings suggest that only subjects lacking both GSTM1 and GSTT1 activity are at increased GC risk. This study provides further support to the hypothesis that the risk of developing GC is influenced by inter-individual variation in both carcinogen detoxification and antioxidant capacity. ' 2005 Wiley-Liss, Inc.

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GST genetic polymorphisms and lung adenocarcinoma susceptibility in a Chinese population

Cited by 81 publications

References 42 publications

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis

Glutathione S-Transferase Polymorphisms and Risk of Differentiated Thyroid Carcinomas

GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population

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