GSTM1 and GSTT1 null polymorphism and antioxidant levels in oral submucous fibrosis, leukoplakia and oral cancer patients among a South Indian Population

Madhulatha, G.; Das, Subhra; Venkateswarlu, N. B.; Pujar, Akhilesh; Jyothy, A.; Munshi, Anjana

doi:10.1016/j.ajoms.2017.11.008

Cited by 3 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, studies investigating the level of antioxidant enzymes in OSMF have produced conflicting results. Lower antioxidant enzyme activity in OSMF patients found in some studies [28,35,36] may be due to depletion of antioxidant defence systems occurring as the consequence of overwhelming free radicals by the elevated levels of oxidative stress. Chitra et al [28] also demonstrated decreased levels of H 2 O 2 and sodium in OSMF.…”

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 92%

“…On the other hand, there are conflicting results from the nine studies (17.3%) comparing antioxidant enzyme status in OSMF patients versus their healthy counterparts. Of these, three found decreased levels [28,35,36], while six found increased levels [8,23,34,[37][38][39] of antioxidant enzymes. Banerjee and colleagues (2020) [40] evaluated mitochondrial antioxidant levels and found higher GSH and peroxiredoxins 3 levels, as well as lower glutaredoxin 2 and catalase levels.…”

Section: Oxidative Stress Biomarkers In the Pathogenesis Of Osmfmentioning

confidence: 99%

“…Glutathione S-transferase (GST), a family of Phase II detoxification enzymes that function to protect cellular macromolecules from attack by reactive electrophiles, are long-time known to protect cells from oxidative stress [84]. However, Bathi, Rao, and Mutalik (2009) [35] and Madhulatha et al (2018) [36] did not observe strong associations between GST gene polymorphisms (GSTM1 and GSTT1) and OSMF. Compared to healthy controls, OSMF patients had considerably elevated levels of glutathione, ceruloplasmin, and malondialdehyde, but reduced levels of beta-carotene, vitamin E, and glutathione peroxidase (GPx).…”

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 99%

See 2 more Smart Citations

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.

show abstract

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 92%

Section: Oxidative Stress Biomarkers In the Pathogenesis Of Osmfmentioning

confidence: 99%

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

View full text Add to dashboard Cite

show abstract

The association of GSTT1 polymorphism with total antioxidant status of nasopharyngeal carcinoma patients

Farhat

Sari

Chrestella

et al. 2021

The INTERNATIONAL CONFERENCE ON CHEMICAL SCIENCE AND TECHNOLOGY (ICCST – 2020): Chemical Science and Technology Innovation for

View full text Add to dashboard Cite

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma: a systematic review with five analyses

Sadafi,

Choubsaz,

Kazemeini

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Glutathione S-transferase theta 1 (GSTT1) enzyme plays a key role in the neutralization of electrophilic compounds such as carcinogens. Herein, we aimed to evaluate GSTT1 deletion polymorphism and susceptibility to head and neck carcinoma (HNC) according to 107 articles in a systematic review with five analyses. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library from the beginning of each database until June 21, 2023, with no restrictions to identify pertinent articles. The RevMan 5.3 software was used to calculate the effect sizes, which were displayed as the odds ratio (OR) along with a 95% confidence interval (CI). Both the publication bias and sensitivity analyses were performed using the CMA 3.0 software. A trial sequential analysis (TSA) was conducted. Of the 1966 records retrieved from four databases, 107 articles were included in the analysis. The combined analysis revealed that the pooled OR was 1.28 (95% CI: 1.14 to 1.44; p-value < 0.0001). The pooled OR was highest in mixed ethnicity. Nasopharyngeal cancer had the highest OR (1.84), followed by oral cancer (OR = 1.20), and laryngeal cancer (OR = 1.17). Studies with less than 200 samples had a higher OR compared to those with 200 or more samples. The studies with a quality score of 7 or more had a higher OR compared to those with a score of less than 7. When both age and sex are considered, while the OR of 1.42 is significant, the high heterogeneity suggests caution in interpreting these results. There is no evidence of publication bias. TSA reported that the study does not have sufficient statistical power. This comprehensive meta-analysis revealed a significant association between the GSTT1 null genotype and an increased risk of HNC, with variations based on factors such as ethnicity, cancer type, sample size, control source, and quality score.

show abstract

GSTM1 and GSTT1 null polymorphism and antioxidant levels in oral submucous fibrosis, leukoplakia and oral cancer patients among a South Indian Population

Cited by 3 publications

References 30 publications

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

The association of GSTT1 polymorphism with total antioxidant status of nasopharyngeal carcinoma patients

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma: a systematic review with five analyses

Contact Info

Product

Resources

About