GSTT1null and rs156697 Polymorphism in GSTO2 Influence the Risk and Therapeutic Outcome of B-Acute Lymphoblastic Leukemia Patients

Baba, Shahid M.; Pandith, Arshad A.; Shah, Zafar A.; Geelani, Sajad; Bhat, Javid Ahmad; Gul, Ayaz; Guru, Sameer Ahmad; El‐Serehy, Hamed A.; Koul, Abid M.; Mansoor, Sheikh

doi:10.3389/fonc.2021.714421

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…Significantly more than 3–times increased risk of ALL in patients has been reported in GSTT1 null and GSTM1 null genotypes. 11 , 16 , 24 Similarly, more than 4–folds increased risk of ALL with combined GSTT1 null and GSTM1 null polymorphisms has also been reported by Baba et al 16 …”

Section: Discussionsupporting

confidence: 56%

“… 12 , 32 GSTT1 and GSTM1 genetic polymorphisms are associated with loss–of–function mutations that leads to the complete loss of activities of these enzymes. 16 In the present study, GSTT1 and GSTM1 genetic polymorphisms were investigated in newly diagnosed adult patients with ALL in Sudanese population. Several studies have investigated the association of GSTT1 and GSTM1 deletions in patients with acute leukemia with conflicting results.…”

Section: Discussionmentioning

confidence: 98%

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Increased Risk of Acute Lymphoblastic Leukemia in Adult Patients with GSTM1 Null Genetic Polymorphism

Abdalhabib

Alzahrani

Alanazi

et al. 2022

PGPM

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Purpose Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous and exogenous compounds and provide cytoprotective role against reactive species. This study aimed to assess the frequency of GSTT1 , and GSTM1 polymorphisms in newly diagnosed Sudanese adult patients with acute lymphoblastic leukemia (ALL) and to evaluate the association of these polymorphisms with age, gender and type of ALL. Patients and Methods This case–control study included 128 adult Sudanese, untreated newly diagnosed patients with ALL, aged 18 to 74 years and 128 age-gender matched healthy controls. Deletional polymorphisms of GSTT1 and GSTM1 genes were genotyped through a multiplex polymerase chain reaction (PCR) assay using β-globin gene as an internal positive control. Results The genotypic frequency of GSTT1 null polymorphism was 22.7% in cases and 14.8% in controls (OR = 1.68, P = 0.111). Statistically significant differences were noted in the frequencies of GSTM1 null polymorphism in cases and controls (OR = 3.7, P = <0.001). Combined GSTT1 null and GSTM1 null gene polymorphisms showed statistically significant difference in patients with ALL as compared to controls (OR = 6.5, CI 95% = 1.42–29.74, P < 0.001). Conclusion Irrespective of age at diagnosis, gender, and phenotype of ALL, GSTM1 null polymorphism either alone or in combination with GSTT1 null polymorphism poses significantly increased risk of developing ALL in adults.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 98%

Increased Risk of Acute Lymphoblastic Leukemia in Adult Patients with GSTM1 Null Genetic Polymorphism

Abdalhabib

Alzahrani

Alanazi

et al. 2022

PGPM

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“…Additionally, cell signaling, post-translational modifications, cell proliferation, differentiation, cellular apoptosis, antiinflammatory, proinflammatory, prevention of DNA damages, and resistance to chemotherapeutic drugs are other non-enzymatic function of GTs (Cerliani et al ., 2016;Singh et al ., 2021). GSTT1 and GSTM1 genetic polymorphisms are associated with loss-of-function mutations that leads to the complete loss of activities of these enzymes (Baba et al, 2021). Most of these finding was compatible with recent studies of (Abdalhabib et al ., 2022 ;Moulik et al ., 2014) Multiple studies have demonstrated that susceptibility to cancer is caused by a deficiency in xenobiotic-metabolism genes (GSTT1 and GSTM1 )were significantly higher in the cases groups compared to the control group (Aziz, 2010) data demonstrated that GST frequent determined in Iraq population GST polymorphism have been related to different cancer some of may be direct associated with cancerogenic toxic factor.…”

Section: Resultssupporting

confidence: 87%

relationship between GSH enzyme with risk of childhood acute lymphoblastic leukemia ALL

Abdullah

Al-Nahi

2022

ijhs

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Total sample number 90 were 60 children diagnosed with Acute lymphoblastic leukemia (ALL) collect form Center Tumor cancer in Najaf , Warith international cancer institute in Karbala and select 30 children normal heath ( control) from Amir al-Muminin Hospital and study conduct with molecular lab biology in the Department of Biology / Faculty of Science – University of Kufa, during the period from November 2021 to April 2022, The study demonstrated that there are highly significant differences in the enzyme GSH between those who carry the allele null in patients and control GSTT1, GSTM1and GSTT1&GSTM1 (2.05±1.40 , 2.27±1.73,2.21±1.5) and (3.7±1.9, 3.2±1.8, 3.86±1.7) respectively , the allele present in patients and control GSTT1, GSTM1,and GSTT1&GSTM1 (5.33±0.38 ,4.78±0.68, 5.03±0.7) , (10.64±1.7 , 9.73±2.7 , 9.9±2.5) respectively.

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“…In addition, one study (Jiang et al, 2008) was excluded because another publication (Jiang and Tan, 2010) included their cases and controls. Therefore, 87 publications (Zintzaras, 2009;Aydin-Sayitoglu et al, 2006;Al-Achkar et al, 2014;Arruda et al, 2001;Allan et al, 2001;Abdalhabib et al, 2021;Alves et al, 2002;Al-Eitan et al, 2016;Bajpai et al, 2007;Balta et al, 2003;Bhat et al, 2012;Bhatla et al, 2008;Barnette et al, 2004;Bolufer et al, 2007;Baba et al, 2021;Bănescu et al, 2016;Bănescu et al, 2014;Chen et al, 1997;Chen et al, 2008;Crump et al, 2000;Chauhan et al, 2011;Chauhan et al, 2012;Canalle et al, 2004;Clavel et al, 2005;Chan et al, 2011;D'Alò et al, 2004;Davies et al, 2000;Davies et al, 2002;Dunna et al, 2013;Eyada et al, 2007;Feng et al, 2004;Farasani, 2019;Gra et al, 2008;Guven et al, 2015;Haase et al, 2002;Hishida et al, 2005;Haranatha Reddy and Jamil, 2006;Idris et al, 2020;Jiang and Tan, 2010;…”

Section: Study Characteristicsmentioning

confidence: 99%

Association Between the Individual and Combined Effects of the GSTM1 and GSTT1 Polymorphisms and Risk of Leukemia: A Meta-Analysis

Zhou

2022

Front. Genet.

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Background: Fourteen meta-analyses reported the individual effects of the GSTM1 and GSTT1 polymorphisms on leukemia risk. However, over 40 studies were not included in previously published meta-analyses. Moreover, one key aspect was that previous meta-analyses did not conduct the false-positive test on the aforementioned issues. Furthermore, previous meta-analyses did not observe the combined effects of GSTM1 present/null and GSTT1 present/null polymorphism with leukemia risk. Therefore, we conducted the current study to further analyze these associations.Objectives: This study aimed to investigate the association between the individual and combined effects of the GSTM1 present/null and GSTT1 present/null polymorphisms and the risk of leukemia.Methods: A meta-analysis was performed applying Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Moreover, false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP) were applied to investigate the false-positive results.Results: The individual GSTM1 and GSTT1 null genotypes and combined effects of the two genes were associated with a significantly increased leukemia risk in overall and several subgroup analyses, such as Asians, Caucasians, and so on. Then, further analysis was conducted using FPRP and BFDP. Significant associations were considered as “positive” results on the GSTM1 null genotype with leukemia risk in overall populations (FPRP < 0.001 and BFDP = 0.006), Asians (FPRP < 0.001 and BFDP < 0.001), and East Asian population (FPRP < 0.001 and BFDP = 0.002). For the GSTT1 null genotype, significant associations were regarded “positive” results in overall populations, acute myeloid leukemia (AML), Asians, and East Asian population. For the combined effects of the GSTM1 and GSTT1 polymorphisms, significant associations were also considered “positive” results in the overall analysis of Asians, Indians, and East Asian population.Conclusion: This study strongly indicates that the individual GSTM1 and GSTT1 null genotypes and combined effects of the two genes are associated with increased leukemia risk in Asians, especially in the East Asian population; the GSTT1 null genotype is associated with increased AML risk; the combined effects of the two genes are associated with increased leukemia risk in Indians.

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GSTT1null and rs156697 Polymorphism in GSTO2 Influence the Risk and Therapeutic Outcome of B-Acute Lymphoblastic Leukemia Patients

Cited by 5 publications

References 48 publications

Increased Risk of Acute Lymphoblastic Leukemia in Adult Patients with GSTM1 Null Genetic Polymorphism

Increased Risk of Acute Lymphoblastic Leukemia in Adult Patients with GSTM1 Null Genetic Polymorphism

relationship between GSH enzyme with risk of childhood acute lymphoblastic leukemia ALL

Association Between the Individual and Combined Effects of the GSTM1 and GSTT1 Polymorphisms and Risk of Leukemia: A Meta-Analysis

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