Guar gum series affect nanostructured lipid carriers via electrostatic assembly or steric hindrance: Improving their oral delivery for phytosterols

Guo, Shu-Jing; Wang, Xue-De; Ma, Yu-Xiang; Hu, Yu-Yuan; Yang, Rui-Nan; Ma, Chuan-Guo

doi:10.1016/j.ijbiomac.2023.126667

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…Due to its linear molecular structure, this suggests that Guar Gum may facilitate a less restrictive matrix, allowing for a more rapid oil diffusion. In a previous study, Guar Gum surface modification led to higher retention ability due to increased steric hinderance [ 40 ]. This sample’s relatively higher D eff value points towards a matrix that permits greater mobility of oil molecules, potentially leading to quicker release rates.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Guar Gum and Xanthan Gum Influence on Essential Thyme Oil Emulsion Properties and Encapsulation Release Using Modeling Tools

Ribeiro,

Almeida,

Batista

et al. 2024

Foods

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This study explores the influence of hydrocolloid interactions between Guar Gum (GG) and Xanthan Gum (XG) on the stability and release dynamics of essential thyme oil emulsions. We systematically characterized six emulsions with varying GG and XG ratios, employing spray-drying techniques for the encapsulation process. The stability of the emulsions was quantitatively analyzed, revealing a marked decrease in stability rates correlated with higher initial emulsion activity (zero-order kinetic constant r = −0.972). Furthermore, this study demonstrated that emulsions with carefully optimized hydrocolloid ratios could achieve high encapsulation efficiency (74%) and controlled release profiles. Kinetic modeling and diffusion analyses elucidated that increased XG concentrations tend to reduce diffusivity, thereby enhancing emulsion stability. The effective diffusivity of the thyme oil within the emulsion matrix was determined to be within a range of 0.7 to 2.4 × 10−10 m2/s, significantly influencing release kinetics. The Pearson correlation matrix underlined a substantial negative association between emulsion activity and effective diffusivity (r = −0.740), indicating that denser hydrocolloid networks impede oil mobility. The findings conclusively establish that the interplay of GG and XG concentrations is pivotal in dictating the emulsion’s physicochemical properties, with denser networks formed by higher XG content leading to slower oil release rates and enhanced stability. This research provides critical insights for the design of encapsulated food and pharmaceutical products, highlighting the imperative of strategic hydrocolloid selection to realize specific functional attributes and performance criteria.

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Section: Resultsmentioning

confidence: 99%

Investigation of Guar Gum and Xanthan Gum Influence on Essential Thyme Oil Emulsion Properties and Encapsulation Release Using Modeling Tools

Ribeiro,

Almeida,

Batista

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…These approaches include the use of several biodegradable polymers, such as polysaccharides and proteins. Polymers can be added to the mixture either before or after NLC develops using the coating process based on electrostatic interaction to form polymer-coated NLC [9,10]. The NLC's size and structure may alter as a result of this coating method due to the intricate interaction between the NLC and coating layer.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Physical Stability and Modified Gastrointestinal Tract Behaviour of Resveratrol-Loaded NLCs Encapsulated Alginate Beads

Manikandan,

Jose,

Karuppaiah

et al. 2024

Preprint

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Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the stability and behaviour of NLC in the alimentary tract by creating an Alginate bead. Through the extrusion dropping procedure, Resveratrol (RES) loaded NLC were efficiently integrated into alginate beads. The incorporation had no significant impact on the particle size, morphology, or inner structure of NLC, as assessed using DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscopy), Differential Scanning Calorimetry (DSC) and FT-IR (Fourier Transform Infra-Red). Incorporating NLC into alginate beads improves its physical stability compared to Dispersion of NLC as well as NLC-Sol. An in vitro release investigation found that the NLC-alginate beads released RES more slowly than optimized NLC formulation (RES-NLCs-opt) and NLC-alginate sol. Research on simulated in vitro digestive models revealed that just a small amount of integrated NLC may permeate stomach fluid due to its tiny size. The slow diffusion of NLC from alginate to intestinal fluid prevented aggregation and allowed for gentle hydrolysis of the lipid matrix. Incorporating NLC in alginate beads shows promise for improving stability, modifying gastrointestinal behaviour, and controlling release throughout the process of digestion.

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The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads

Manikandan,

Jose,

Karuppaiah

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the stability and behaviour of NLC in the alimentary tract by creating an Alginate bead. Through the extrusion dropping procedure, Resveratrol (RES) loaded NLC were e ciently integrated into alginate beads. The incorporation had no signi cant impact on the particle size, morphology, or inner structure of NLC, as assessed using DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscopy), Differential Scanning Calorimetry (DSC) and FT-IR (Fourier Transform Infra-Red). Incorporating NLC into alginate beads improves its physical stability compared to Dispersion of NLC as well as NLC-Sol. An in vitro release investigation found that the NLC-alginate beads released RES more slowly than optimized NLC formulation (RES-NLCs-opt) and NLC-alginate sol. Research on simulated in vitro digestive models revealed that just a small amount of integrated NLC may permeate stomach uid due to its tiny size. The slow diffusion of NLC from alginate to intestinal uid prevented aggregation and allowed for gentle hydrolysis of the lipid matrix. Incorporating NLC in alginate beads shows promise for improving stability, modifying gastrointestinal behaviour, and controlling release throughout the process of digestion.

show abstract

Guar gum series affect nanostructured lipid carriers via electrostatic assembly or steric hindrance: Improving their oral delivery for phytosterols

Cited by 6 publications

References 45 publications

Investigation of Guar Gum and Xanthan Gum Influence on Essential Thyme Oil Emulsion Properties and Encapsulation Release Using Modeling Tools

Investigation of Guar Gum and Xanthan Gum Influence on Essential Thyme Oil Emulsion Properties and Encapsulation Release Using Modeling Tools

The Effect of Physical Stability and Modified Gastrointestinal Tract Behaviour of Resveratrol-Loaded NLCs Encapsulated Alginate Beads

The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads

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