Guarana: Revisiting a highly caffeinated plant from the Amazon

Schimpl, Flávia Camila; Silva, José Ferreira da; Gonçalves, José Francisco de Carvalho; Mazzafera, Paulo

doi:10.1016/j.jep.2013.08.023

Cited by 161 publications

(122 citation statements)

References 64 publications

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“…Guarana possesses biological properties described in the literature as anti-inflammatory (29), antidepressant (30), panicolytic (31) and energetic (6), which may help minimize CRF, as previously reported (7,8). Other studies have also described the antitumor activity of guarana using animal and cell experimental models (32)(33)(34).…”

Section: Discussionmentioning

confidence: 68%

“…For this reason, de Oliveira Campos et al (6) performed a phase II randomized, double-blind, placebo-controlled crossover study to evaluated the effect of guarana (Paullinia cupana) against CRF. Guarana is an Amazon fruit used since the pre-Columbian era that is currently commercialized in herbal and energetic beverages due to its stimulant properties (7).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Hertz

Cadoná

Machado

et al. 2014

Molecular and Clinical Oncology

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Abstract. Previous studies suggested that certain plants, such as guarana (Paullinia cupana), exert a protective effect against cancer-related fatigue in breast cancer patients undergoing chemotherapy. However, guarana possesses bioactive molecules, such as caffeine and catechin, which may affect the pharmacological properties of antitumor drugs. Therefore, the aim of this study was to evaluate the effects of guarana on breast cancer cell response to 7 chemotherapeutic agents currently used in the treatment of breast cancer. To perform this study, MCF-7 breast cancer cells were cultured under controlled conditions and exposed to 1, 5 and 10 µg/ml guarana concentrations, with and without chemotherapeutics (gemcitabine, vinorelbine, methotrexate, 5-fluorouracil, paclitaxel, doxorubicin and cyclophosphamide). The effect of these treatments on MCF-7 cell viability and proliferation was spectrophotometrically analyzed with the MTT assay. The main results demonstrated an antiproliferative effect of guarana at concentrations of 5 and 10 µg/ml and a significant effect on chemotherapeutic drug action. In general, guarana improved the antiproliferative effect of chemotherapeutic agents, causing a decrease of >40% in cell growth after 72 h of exposure. The results suggested an interaction of guarana with the chemotherapeutic drugs, which requires confirmation by in vivo complementary studies.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Hertz

Cadoná

Machado

et al. 2014

Molecular and Clinical Oncology

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“…Schimpl et al (2013) reported that guarana contained 6% of caffeine, with other purinic alkaloids in smaller proportions (below 0.3%): theobromine (3,7-dimethylxanthine) and theophylline (1,3-dimethyl-xanthine). Antioxidant-Capacity) assay Table 2 shows the results obtained in the TEAC assay at different times (1, 3, 6 min).…”

Section: Gas Chromatography/mass Spectrometry (Gc-ms) Profilementioning

confidence: 99%

“…Guarana is a native Brazilian plant, the seeds being the only part suitable for human consumption. It is the richest vegetable source of caffeine (MAJHENIC et al, 2007), and the seeds contain bioactive components (phenols, proanthocyanidins, caffeine and catechins) with antioxidant and antimicrobial properties of interest to the food, pharmaceutical and cosmetic industries (SCHIMPL et al, 2013). On the other hand, boldo leaves is an endemic Chilean plant.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial properties of ethanolic extracts of guarana, boldo, rosemary and cinnamon

Bonilla

Sobral

2017

Braz. J. Food Technol.

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In this investigation, the ethanolic extracts of two less known plants, little reported in the literature (guarana and boldo leaves) were studied in comparison with the ethanolic extracts of two well studied plants (cinnamon and rosemary), regarding their colour, GC-MS profile, phenolic content and their antioxidant and antimicrobial properties. The rosemary (59.20 ± 0.28) and guarana (56.63 ± 0.54) extracts showed the highest values for luminosity (L*) and the UV-Vis absorption increased when L* decreased. GC-MS identified a limited number of compounds in the cinnamon and guarana extracts. The cinnamon extract showed the highest value for the total phenolic content (172 mg GA/g extract) as compared to the other extracts. The highest antioxidant capacity was observed for the boldo leaves extract in the TEAC (6.66 ± 0.17 mM) assay and for the rosemary extract in the DPPH (0.80 ± 0.14 mg/L) test. In addition, all the extracts showed antimicrobial activity against the S. aureus strain, indicating that all the extracts studied could be used by food industries to develop new active food packaging materials.Keywords: Herbs; Seeds; Phenols; Volatile compounds; S. aureus; E. coli. ResumoNesta investigação, foram estudados dois extratos etanólicos de plantas pouco conhecidas na literatura (guaraná e boldo-do-chile), em comparação com os extratos etanólicos de duas plantas bastante estudadas (canela e alecrim), quanto aos parâmetros de cor, perfil GC-MS, teor fenólico e propriedades antioxidantes e antimicrobianas. Os extratos de alecrim (59,20 ± 0,28) e guaraná (56,63 ± 0,54) mostraram os maiores valores de luminosidade (L*). A absorção de radiação ultravioleta visível (UV-Vis) aumentou de intensidade quando o valor L* diminuiu. Na análise do perfil GC-MS, identificou-se um número limitado de compostos nos extratos de canela e guaraná. O extrato de canela apresentou o maior conteúdo de compostos fenólicos totais (172 mg GA/g extrato), em comparação com outros extratos. A maior capacidade antioxidante foi observada para o extrato de boldo-do-chile, no ensaio TEAC (6,66 ± 0,17 mM), e para o extrato de alecrim, no teste de DPPH (0,80 ± 0,14 mg/L). Adicionalmente, todos os extratos mostraram atividade antimicrobiana contra a cepa S. aureus, indicando que todos os extratos estudados podem ser utilizados pelas indústrias de alimentos para desenvolver novos materiais ativos de embalagem de alimentos. Palavras

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“…sorbilis) is a native plant from the central amazon basin, belonging to the family Sapindaceae. The genus Paullinia, with approximately 200 species, is restricted to this region with few exceptions on the tropical and subtropical America [5]. The guarana seed extract has many pharmacological activities, but it is mainly consumed as a soft drink generated from industries that produce nonalcoholic beverages.…”

Section: Introductionmentioning

confidence: 99%

Endophytic cultivable bacterial community obtained from the Paullinia cupana seed in Amazonas and Bahia regions and its antagonistic effects against Colletotrichum gloeosporioides

Silva¹,

Polônio

Quecine³

et al. 2016

Microbial Pathogenesis

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Guarana (Paullinia cupana var. sorbilis) is a plant from the Amazonas region with socio-economic importance. However, guarana production has been increasingly affected by unfavorable conditions resulting from anthracnose, caused by the Colletotrichum fungal genus, which primarily affects mainly the Amazonas region. The aim of the present study was to isolate bacterial endophytes from the seeds of guarana plants obtained from Amazonas region and the Northeast state of Bahia, a region where this disease is not a problem for guarana plantations. The number of bacterial Colony Forming Units (CFU/g seeds) was 2.4 × 10(4) from the Bahia and 2.9 × 10(4) from the Amazonas region. One hundred and two isolated bacteria were evaluated in vitro against the phytopathogenic strain Colletotrichum gloeosporioides L1. These isolates were also analyzed for the enzymatic production of amylase, cellulase, protease, pectinase, lipase and esterase. Approximately 15% of isolates, showing high antagonistic activity, and the production of at least one enzyme were identified through the partial sequencing of 16S rDNA. The genus Bacillus was the most frequently observed, followed by Paenibacillus, Ochrobactrum, Microbacterium and Stenotrophomonas. Proteolytic activity was observed in 24 isolates followed by amylolytic, pectinolytic and cellulolytic activities. No esterase and lipase production was detected. Most of the isolates, showing antagonistic effects against C. gloeosporioides and high enzymatic activities, were isolated from the anthracnose-affected region. A biocontrol method using the endophytes from guarana seeds could be applied in the future, as these bacteria are vertically transferred to guarana seedlings.

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Guarana: Revisiting a highly caffeinated plant from the Amazon

Cited by 161 publications

References 64 publications

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Antioxidant and antimicrobial properties of ethanolic extracts of guarana, boldo, rosemary and cinnamon

Endophytic cultivable bacterial community obtained from the Paullinia cupana seed in Amazonas and Bahia regions and its antagonistic effects against Colletotrichum gloeosporioides

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