Guidable Thermophoretic Janus Micromotors Containing Gold Nanocolorifiers for Infrared Laser Assisted Tissue Welding

He, Wenping; Frueh, Johannes; Hu, Narisu; Liu, Liping; Gai, Meiyu; He, Qiang

doi:10.1002/advs.201600206

Cited by 126 publications

(94 citation statements)

References 35 publications

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“…Thermophoretic Janus micromotors fabricated by layer‐by‐layer (LbL) self‐assembly with embedded magnetic nanoparticles and a gold cap also showed great potential for surgical purposes, being used as autonomously moving dyes. The micromotors were guided and exposed to near infrared light for infrared laser‐assisted welding . Albumin presence was required to achieve a successful photothermal tissue welding, as it acts as tissue glue due to the thermal denaturation process that the protein undergoes when exposed to IR light.…”

Section: Applicationsmentioning

confidence: 99%

Self‐Propelled Micro/Nanoparticle Motors

Guix

Weiz

Schmidt

et al. 2018

Part & Part Syst Charact

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resulted in a forward motion. Here, the thermodynamic forces act over the inertial thrust. Variations of this motion principle have been reported over the last decade and they will be discussed accordingly in the following sections depending on the micromotor design and the energy source used for its propulsion (i.e., concentration gradient, electric fields, magnetic fields, thermal gradients). Additionally, different approaches to improve the performance in terms of velocity, control, lifetime, and functionality will be covered. However, there are certain constraints on the synthetic autonomous nano-and microparticle performance, such as poor interaction with the surrounding environment (i.e., biological entities) and lack of sensing capabilities, in addition to low lifespan or related toxicity issues. Therefore, biohybrid particulate micromotors appear as a promising solution to overcome such hurdles. They take advantage of the tailored and advanced functions of biological cells or microorganism, such as self-propulsion, sensing, and cargo capabilities, as well as their ability to interact with other cells. Together with the controllability of engineered microobjects, hybrid micro-and nanomotors represent a promising tool for diverse biomedical and environmental applications, where the main power source comes from their natural environment. [11] As shown in Figure 1, in this review we classify micro-and nanoparticle micromotors in two main categories: synthetic and biohybrids. The synthetic micromotors are then divided according to their propulsion mechanism, as follows: those propelled by a catalytic reaction, by optical stimuli, under magnetic fields, with ultrasound steering, electricity, and thermophoresis, respectively. Likewise, the biohybrids are classified as those propelled by bacteria and those employing enzymes as main energy source, respectively. Additionally, we point out the different methods that have been proposed during the last decade to guide the particles and the related collective behavior. We also discuss the potential applications and remaining challenges in the final section of the review. Synthetic Micro/Nanoparticle MotorsThe development of the first sphere-like synthetic micro-and nanomachines with their rotationally symmetric shape was particularly challenging. As per se, they contradict the first rule in the design of microscale devices aiming to perform an effective motility in response to specific energy input: they must present asymmetry. Such symmetry breaking can be associated with shape or the distribution of a certain reactive The growing interest in the design and fabrication of novel autonomous micro-and nanoparticles is motivated by the vast advances in their motion efficiency and their further implementation in both biomedical and environmental fields. The present review covers the motion principle and fabrication procedures of synthetic and hybrid particle-like micromotors reported to date to give a comprehensive view of the key design parameters and different approaches...

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Section: Applicationsmentioning

confidence: 99%

Self‐Propelled Micro/Nanoparticle Motors

Guix

Weiz

Schmidt

et al. 2018

Part & Part Syst Charact

View full text Add to dashboard Cite

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“…It should also be noted that new research directions are starting to emerge within these surgical practices. Auxiliary technological devices and instrumentation, such as robotic-assisted surgeries with enhanced image-processing systems [85][86][87], as well as the development of new biomaterials based on nanotechnology [88,89], show a great potential for driving the future evolution of reconstructive vascular and nervous laser welding.…”

Section: Appl Sci 2019 9 X For Peer Review 9 Of 15mentioning

confidence: 99%

Overview on the Evolution of Laser Welding of Vascular and Nervous Tissues

2019

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Laser welding presents a core position in the health sector. This process has had an outstanding impact on the surgical procedures from many medical areas, such as on vascular and nervous surgeries. The aim of the present research is to present an overview on the evolution of laser welding of vascular and nervous tissues. These surgeries present many advantages, such as an absence of foreign-body reactions and aneurysms and good tensile strengths. However, despite the sutureless nature of the process, complementary sutures have been applied to support the procedure success. An important concern in vascular and nervous laser welding is the thermal damage. The development of temperature-controlled feedback systems has reduced this concern with a very precise control of the laser parameters. The bonding strength of vascular and nerve laser welds can be enhanced with the application of solder solutions, bonding materials, and laser-activated dyes. Alternative techniques to laser welding, such as photochemical tissue bonding and electrosurgical high-frequency technologies, have also been tested for vascular and nervous repairs.

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“…Recently, light‐driven micromotor has attracted more attention due to the fact that light is an easily accessible and environmental‐friendly energy source with remotely controlled feature. The application of light on a micromotor can activate its movement behavior based on either the photochemical reaction, photothermal effect, or photochromism . As a result, fuel‐free micromotors have been developed, thus avoiding the utilization of toxic chemical fuels.…”

Section: Introductionmentioning

confidence: 99%

A Light‐Driven Micromotor with Complex Motion Behaviors for Controlled Release

Sun

Liu

Song

et al. 2019

Adv Materials Inter

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Recently, light-driven micromotor has attracted more attention due to the fact that light is an easily accessible and environmental-friendly energy source with remotely controlled feature. The application of light on a micromotor can activate its movement behavior based on either the photochemical reaction, [21] photothermal effect, [32][33][34] or photochromism. [35] As a result, fuel-free micromotors have been developed, thus avoiding the utilization of toxic chemical fuels. In addition, the light-driven methodology also enables the instant on-off switch and the manipulation of the moving direction, which is of great importance when utilized in cargo capture and transportation-related applications. Despite these progresses, few studies on the light-driven micromotor have focused on the control over the solution flow surrounding it, which, if realized, may have great potential in the field of mass transportation and targeted delivery.In this work, we report a novel light-driven sheet-like micromotor based on polypyrrole nanoparticles (PPyNPs). This micromotor exhibits both the controlled translational motion and the surrounding water flow in the surfactant solution when irradiated by near-infrared (NIR) light. The movement of this micromotor relies on the Marangoni effect resulting from the light irradiation of the PPy material, which is tuned by adjusting the incident light angle, thus leading to precisely controlled motion behavior and water flow surrounding it. Interestingly, this combined motion enables the micromotor to deliver and release the adsorbed payload in a desirable fashion. We thus believe that the current study paves the way towards the development of micromotor with diverse functions for practical applications.

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Guidable Thermophoretic Janus Micromotors Containing Gold Nanocolorifiers for Infrared Laser Assisted Tissue Welding

Cited by 126 publications

References 35 publications

Self‐Propelled Micro/Nanoparticle Motors

Self‐Propelled Micro/Nanoparticle Motors

Overview on the Evolution of Laser Welding of Vascular and Nervous Tissues

A Light‐Driven Micromotor with Complex Motion Behaviors for Controlled Release

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