The study was theoretically and philosophically guided by the Theory of Human Care, entailing the use of the Elements of the Clinical Caritas Process, having humanistic assumptions based on Home Care, and being operationalized by the following action steps: Initial Contact, Approaching, Transpersonal Encounter and Separation. It aimed to apply the Transpersonal Care Model in Home Care Nursing to children with special healthcare needs. Qualitative care-research (intervention), developed by means of five components: approaching the studied object; encounter with the cared-researched being; connections between theory and practice; separation from the researcher-caregiver being to the cared-researched being, and analysis of what has been learned by means of the General Analytical Strategy – Relying on theoretical propositions – and Specific Analytical Technique – Pattern Combination. The key results from the development of each one of the steps are, as follows: assumptions were applied 537 times, 322 usages of the Clinical Caritas Process, and 467 care needs were met by means of the model. The model potentialities were identified, understanding that it was built for the population at home care, thus enabling relation development, meeting their needs, and supporting nurses to foster care delivery.