Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs

Abstract

Objectives: The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration. Materials and methods: In five adult German sheepdogs, the mandibular premolars P2, P3, P4, and the molar M1 were bilaterally extracted creating two bony defects on each site. A total of 20 dental implants were inserted and allocated to four different treatment modalities within each dog: PLGA/NMP membrane only (Test 1), PLGA/NMP membrane with DBBM (Test 2), RCM only (negative control), and RCM with DBBM (positive control). A histomorphometric analysis was performed 12 weeks after implantation. For statistical analysis, a Friedman test and subsequently a Wilcoxon signed ranks test were applied. Results: In four out of five PLGA/NMP membrane-treated defects, the membranes had broken into pieces without the support of DBBM. This led to a worse outcome than in the RCM group. In combination with DBBM, both membranes revealed similar amounts of area of bone regeneration and bone-to-implant contact without significant differences. On the level of the third implant thread, the PLGA/NMP membrane induced more horizontal bone formation beyond the graft than the RCM. Conclusion: The newly developed PLGA/NMP membrane performs equally well as the RCM when applied in combination with DBBM. Without bone substitute material, the PLGA/NMP membrane performed worse than the RCM in challenging defects, and therefore, a combination with a bone substitute material is recommended. To cite this article: Jung RE, Kokovic V, Jurisic M, Yaman D, Subramani K, Weber FE. Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs. Clin. Oral Impl. Res. xx, 2010; 000-000. Guided bone regeneration with a synthetic Conflicts of interest:The authors declare no conflicts of interest.Keywords: guided bone regeneration, PLGA membrane, dog study

A randomized controlled clinical multicenter trial comparing the clinical and histological performance of a new, modified polylactide‐co‐glycolide acid membrane to an expanded polytetrafluorethylene membrane in guided bone regeneration procedures

“…Human histological data from earlier time points, however, are not available from the literature. Fragmentation of the test membrane, as it was reported in an earlier preclinical study when used without any bone substitute material, was not histologically observed in the present study (Jung et al 2011).…”

“…In a recent preclinical investigation, it was demonstrated that the membrane was totally fragmented after 6 months and completely resorbed after 12 months (Nieminen et al 2006). In another study in dogs, the histological analysis revealed that the test membrane was broken into pieces due to its stiffness and brittleness when the membrane was not supported by grafting materials (Jung et al 2011). Therefore, the tenting effect of the PLGA/NMP membrane was apparently not sufficient to maintain the space for regeneration.…”

Clinical use of the resorbable bioscaffold poly lactic co-glycolic acid (PLGA) in post-extraction socket for maintaining the alveolar height: A prospective study

“…It can be used as a space filler 10,11,[19][20][21] or a membrane. 2,22,23 In our study, we used PLGA copolymer in the form of scaffolds. The scaffold serves to provide a temporary structure for cells to proliferate and maintain their differentiated function before being resorbed by the body.…”

Guided Bone Regeneration Using Cyanoacrylate-Combined Calcium Phosphate in a Dehiscence Defect: A Histologic Study in Dogs

“…[19][20][21][22] One candidate for such a substitute is cyanoacrylate glue. Cyanoacrylate is a tissue-adhesive material that promotes the rapid adhesion of soft and hard tissues.…”