Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group

Husain, Aliya N.; Colby, Thomas V.; Ordóñez, Nelson G.; Krausz, Thomas; Attanoos, Richard; Beasley, Mary Beth; Borczuk, Alain C.; Butnor, Kelly J.; Cagle, Philip T.; Chirieac, Lucian R.; Churg, Andrew; Đačić, Sanja; Fraire, Armando E.; Galateau-Salle, Françoise; Gibbs, A R; Gown, Allen M.; Hammar, Samuel P.; Litzky, Leslie A.; Marchevsky, Alberto M.; Nicholson, Andrew G.; Roggli, Victor L.; Travis, William D.; Wick, Mark R.

doi:10.5858/arpa.2012-0214-oa

Cited by 479 publications

(595 citation statements)

References 89 publications

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“…The 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group guidelines recognized difficulties with pattern recognition in small biopsies, and recommended using three main histological types (epithelioid, sarcomatoid, biphasic) with pattern descriptions in medical records, if possible [13]. Histological subtyping/patterns in many carcinomas correlate with patients' clinicopathological characteristics [17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…and S.S.) and classified as epithelioid, sarcomatoid or biphasic type, according to the 2004 WHO classification criteria for pleural tumors [9], and used a median of 3 slides per case (range: 1-16). Epithelioid MPM were further subtyped according to their predominant patterns as acinar, adenomatoid (microglandular), micropapillary, solid, tubulopapillary, and trabecular as defined previously [11,13,14] (Fig. 1 and 2).…”

Section: Methodsmentioning

confidence: 99%

“…The importance of histological subtyping lies in their significant bearing on survival, with epithelioid having the best prognosis [11], whereas the pleomorphic subtype and sarcomatoid MPMs both reportedly have similarly poor outcomes [12]. The 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group recommended that MPM diagnoses include subtype if possible, with histological pattern in the description [13]. So far, only Kadota et al have comprehensively subtyped epithelioid mesothelioma and correlated its clinicopathological characteristics and prognosis, mainly using extrapleural pneumectomy and pleurectomy decortication samples; their study suggested reclassifying pleomorphic epithelioid mesothelioma as a biphasic or sarcomatoid type based on its very poor survival [11], which accords with an earlier study by Ordonez who analyzed 10 pleomorphic mesotheliomas [12].…”

Section: Introductionmentioning

confidence: 99%

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Reproducibility of histological subtyping of malignant pleural mesothelioma

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reproducibility of histological subtyping of malignant pleural mesothelioma

et al. 2014

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“…The epithelioid variety has a much better prognosis as compared to the other varieties and is treated aggressively. The cytological and histologic features of MPM have been described in recent articles [43,44]. The tumor arises from mesothelial cells lining the peritoneal cavity.…”

Section: Peritoneal Mesothelioma (Mpm)mentioning

confidence: 99%

Role of Imaging in Peritoneal Surface Malignancies

Krishnamurthy

Balasubramaniam

2016

Indian J Surg Oncol

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“…Both cell lines expressed keratin 5/6, podoplanin, WT1, calretinin and mesothelin which are often used as mesothelioma markers for pathological diagnosis (11). On the other hand, neither cell line expressed TTF-1 or CEA; they are not generally expressed in MPM, and are often used as markers of lung adenocarcinoma (11). The expressions of those marker genes of mesothelioma and origin of HMM-1 and HMM-3 cell lines suggested that the two cell lines were mesothelioma cells.…”

Section: Characterization Of Newly Established Mpm Cell Linesmentioning

confidence: 99%

Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma

et al. 2013

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Human malignant pleural mesothelioma (MPM) is highly aggressive, and its prognosis is very poor. For an early diagnosis of MPM and developing new therapeutic strategies against the malignancy, it is necessary to better understand biological characteristics of MPM. In this study, we established two cell lines from pleural effusions derived from patients with MPM. Both cell lines expressed tumor markers of mesothelioma such as mesothelin, podoplanin, WT1, calretinin and keratin 5/6 whereas they did not express either CEA or TTF-1 which are often used as markers of lung adenocarcinoma. The cell lines harboured wild-type TP53, produced hyaluronic acid, and were not infected with SV40. When these two cell lines were cultured under hypoxia (1% O 2 ), they showed particular responses to the hypoxic condition, distinct from those to normoxic condition (21% O 2 ). Namely, the ability to form a colony originating from a single cell (plating efficiency and cloning efficiency) was stimulated under hypoxia in both cell lines. On the other hand, when the assays of cell growth were started at a relatively high cell density, the growth of both cell lines, regardless of anchorage-dependent or -independent, decreased under hypoxia. The differences of their growth between under hypoxia and under normoxia, and those depending on the cell density, may provide useful hints for developing a new strategy for diagnosis or therapy of MPM.

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Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group

Cited by 479 publications

References 89 publications

Reproducibility of histological subtyping of malignant pleural mesothelioma

Reproducibility of histological subtyping of malignant pleural mesothelioma

Role of Imaging in Peritoneal Surface Malignancies

Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma

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