Guidelines for quality assurance in intra-operative radiation therapy

In vivo dosimetry in intraoperative electron radiotherapy

“…With respect to the uncertainties of the dosimeters, they are comparable with those that can be found in the literature [5,6,9] and not greater. The standard deviation of the measured absorbed doses is about two or three times the detector uncertainty, but this is not a pitfall from the point of view of the authors.…”

“…In vivo dosimetry is desirable for the verification, recording, and eventual correction of treatment and is advised to be performed [5]. Detectors based on metal oxide semiconductor field-effect transistors (MOSFETs) [6][7][8][9] and radiochromic films [10,11] have been investigated for these purposes.…”

Dosimetry for electron Intra-Operative RadioTherapy: Comparison of output factors obtained through alanine/EPR pellets, ionization chamber and Monte Carlo-GEANT4 simulations for IORT mobile dedicate accelerator

“…The electron beams were calibrated using chemical Fricke dosimeters as recommended in Guidelines for Quality Assurance in IORT [36]. The rationale for this choice is that the response of chemical dosimeters is independent of dose rate and beam energy.…”

Determination of the ion recombination correction factor for intraoperative electron beams

“…This therapy option allows achieving a selective radiation boost on the tumor volume. In some cases, it can also be used as a single-fraction/stand-alone treatment in initial cancers of small volume, or in unresectable malignancies for palliative purposes [1,2]. IORT treatments can be realized using dedicated electron linear accelerators that produce high dose-per-pulse electron beams, which in particular significantly shortens the treatment time compared to other methods [3].…”