Guidelines for the Management of Respiratory Complications in Patients With Neuromuscular Disease

Farrero, Eva; Antón, Antonio; Egea, Carlos; Almaraz, Moro; Masa, Juan F.; Utrabo, Isabel; Calle, Miriam; Verea, Héctor; Servera, Emilio; Jara, Luis; Barrot, Emilia; Casolivé, Vinyet

doi:10.1016/j.arbr.2013.05.005

Cited by 21 publications

(40 citation statements)

References 33 publications

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“…17,18 However, recent guidelines recommend the commencement of NIV in the presence of symptoms of hypoventilation, hypercapnia, or rapid reduction in FVC despite a fixed percent-of-predicted FVC. 19 The findings of this study show that a baseline FVC of Ͻ 55% of predicted in a stable condition suggests ineffective ventilatory capacity during acute chest episodes. A reduced FVC in patients with ALS is related to respiratory muscle weakness; however, a poor correlation between FVC and symptoms, respiratory muscle strength, and sleep-related breathing disorders has been described.…”

Section: Discussionmentioning

confidence: 83%

Predictors of Need for Noninvasive Ventilation During Respiratory Tract Infections in Medically Stable, Non-Ventilated Subjects With Amyotrophic Lateral Sclerosis

et al. 2014

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BACKGROUND: Acute lower respiratory infections can impair muscle strength in patients with amyotrophic lateral sclerosis (ALS). When associated with an increase in load on the respiratory system, this situation may precipitate hypercapnic respiratory failure in non-ventilated patients with ALS. The aim of this study was to determine whether a clinical or functional parameter can predict the need for noninvasive ventilation (NIV) during an acute respiratory infection for medically stable, non-ventilated patients with ALS. METHODS: This was a prospective study involving all non-ventilated subjects with ALS admitted due to an acute respiratory infection to a respiratory care unit from a tertiary hospital. RESULTS: Thirty-two non-ventilated subjects with ALS were admitted to our respiratory care unit due to an acute respiratory infection: 60. 72

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Section: Discussionmentioning

confidence: 83%

Predictors of Need for Noninvasive Ventilation During Respiratory Tract Infections in Medically Stable, Non-Ventilated Subjects With Amyotrophic Lateral Sclerosis

et al. 2014

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“…Un descenso en la FVC mayor del 25% entre espirometrías realizadas en sedestación y en decúbito supino, o una FVC inferior al 75% de los valores de referencia en decúbito supino, con valores normales en sedestación, indican debilidad diafragmática 29 .…”

Section: Evaluación De Los Músculos Respiratorios: Maniobras Voluntarunclassified

Normativa SEPAR sobre disfunción muscular de los pacientes con enfermedad pulmonar obstructiva crónica

Barreiro

Bustamante

Cejudo

et al. 2015

Archivos de Bronconeumología

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In patients with chronic obstructive pulmonary disease (COPD), skeletal muscle dysfunction is a major comorbidity that negatively impacts their exercise capacity and quality of life. In the current guidelines, the most recent literature on the various aspects of COPD muscle dysfunction has been included. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) scale has been used to make evidence-based recommendations on the different features. Compared to a control population, one third of COPD patients exhibited a 25% decline in quadriceps muscle strength, even at early stages of their disease. Although both respiratory and limb muscles are altered, the latter are usually more severely affected. Numerous factors and biological mechanisms are involved in the etiology of COPD muscle dysfunction. Several tests are proposed in order to diagnose and evaluate the degree of muscle dysfunction of both respiratory and limb muscles (peripheral), as well as to identify the patients' exercise capacity (six-minute walking test and cycloergometry). Currently available therapeutic strategies including the different training modalities and pharmacological and nutritional support are also described.

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“…4), which allows better psychosocial support and care coordination. In addition to coordinated personnel, consensus statements and clinical practice guidelines are now available and provide exhaustive standardof-care directions for patients with neuromuscular diseases [3,12,[27][28][29][30].…”

Section: Coordinated Approach To Patient Carementioning

confidence: 99%

Pulmonary Manifestations of Neuromuscular Diseases

Khatwa

2015

Indian J Pediatr

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Neuromuscular disorders comprise a phenotypically diverse group of inherited and acquired diseases; however, they share common pathophysiologic mechanisms which produce significant respiratory complications. Respiratory and bulbar muscle weakness gives rise to ineffective cough, swallowing dysfunction results in aspiration-related lung disease, and abnormal muscle tone produces chest wall deformities - all of which ultimately leads to repeated chest infections and chronic respiratory failure. In this article, the authors describe the respiratory manifestations of neuromuscular disease and their underlying pathophysiological mechanisms. This review also highlights the diagnostic and management tools recommended for acute and chronic care. Aggressive pulmonary management is the most impactful at reducing the overall morbidity and improving the quality of life of children with neuromuscular disorders, at least while definitive molecular and gene replacement therapies remain elusive.

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Guidelines for the Management of Respiratory Complications in Patients With Neuromuscular Disease

Cited by 21 publications

References 33 publications

Predictors of Need for Noninvasive Ventilation During Respiratory Tract Infections in Medically Stable, Non-Ventilated Subjects With Amyotrophic Lateral Sclerosis

Predictors of Need for Noninvasive Ventilation During Respiratory Tract Infections in Medically Stable, Non-Ventilated Subjects With Amyotrophic Lateral Sclerosis

Normativa SEPAR sobre disfunción muscular de los pacientes con enfermedad pulmonar obstructiva crónica

Pulmonary Manifestations of Neuromuscular Diseases

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